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Literature DB >> 18536803

Single molecule conformational analysis of the biologically relevant DNA G-quadruplex in the promoter of the proto-oncogene c-MYC.

Pravin S Shirude¹, Liming Ying, Shankar Balasubramanian.

Abstract

Single molecule fluorescence spectroscopy has been employed to resolve the conformational heterogeneity, hybridization kinetics and study mutational effects on the c-MYC promoter G-quadruplex.

Entities: Chemical Disease Gene Species

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Year: 2008 PMID： 18536803 PMCID： PMC2426741 DOI： 10.1039/b801465e

Source DB: PubMed Journal: Chem Commun (Camb) ISSN： 1359-7345 Impact factor: 6.222

20 in total

1. Studies on the structure and dynamics of the human telomeric G quadruplex by single-molecule fluorescence resonance energy transfer.

Authors: Liming Ying; Jeremy J Green; Haitao Li; David Klenerman; Shankar Balasubramanian
Journal: Proc Natl Acad Sci U S A Date: 2003-11-25 Impact factor: 11.205

2. Direct evidence for a G-quadruplex in a promoter region and its targeting with a small molecule to repress c-MYC transcription.

Authors: Adam Siddiqui-Jain; Cory L Grand; David J Bearss; Laurence H Hurley
Journal: Proc Natl Acad Sci U S A Date: 2002-08-23 Impact factor: 11.205

3. Kinetics of unfolding the human telomeric DNA quadruplex using a PNA trap.

Authors: Jeremy J Green; Liming Ying; David Klenerman; Shankar Balasubramanian
Journal: J Am Chem Soc Date: 2003-04-02 Impact factor: 15.419

4. An intramolecular G-quadruplex structure with mixed parallel/antiparallel G-strands formed in the human BCL-2 promoter region in solution.

Authors: Jixun Dai; Thomas S Dexheimer; Ding Chen; Megan Carver; Attila Ambrus; Roger A Jones; Danzhou Yang
Journal: J Am Chem Soc Date: 2006-02-01 Impact factor: 15.419

5. In vitro generated antibodies specific for telomeric guanine-quadruplex DNA react with Stylonychia lemnae macronuclei.

Authors: C Schaffitzel; I Berger; J Postberg; J Hanes; H J Lipps; A Plückthun
Journal: Proc Natl Acad Sci U S A Date: 2001-07-03 Impact factor: 11.205

6. An RNA G-quadruplex in the 5' UTR of the NRAS proto-oncogene modulates translation.

Authors: Sunita Kumari; Anthony Bugaut; Julian L Huppert; Shankar Balasubramanian
Journal: Nat Chem Biol Date: 2007-02-25 Impact factor: 15.040

7. A conserved quadruplex motif located in a transcription activation site of the human c-kit oncogene.

Authors: Himesh Fernando; Anthony P Reszka; Julian Huppert; Sylvain Ladame; Sarah Rankin; Ashok R Venkitaraman; Stephen Neidle; Shankar Balasubramanian
Journal: Biochemistry Date: 2006-06-27 Impact factor: 3.162

8. G-quadruplex formation within the promoter of the KRAS proto-oncogene and its effect on transcription.

Authors: Susanna Cogoi; Luigi E Xodo
Journal: Nucleic Acids Res Date: 2006-05-10 Impact factor: 16.971

9. G-quadruplexes in promoters throughout the human genome.

Authors: Julian L Huppert; Shankar Balasubramanian
Journal: Nucleic Acids Res Date: 2006-12-14 Impact factor: 16.971

10. Single-molecule conformational analysis of G-quadruplex formation in the promoter DNA duplex of the proto-oncogene c-kit.

Authors: Pravin S Shirude; Burak Okumus; Liming Ying; Taekjip Ha; Shankar Balasubramanian
Journal: J Am Chem Soc Date: 2007-05-25 Impact factor: 15.419

4 in total