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Literature DB >> 18507461

Diacid linkers that promote parallel beta-sheet secondary structure in water.

Felix Freire¹, John D Fisk, Aaron J Peoples, Monika Ivancic, Ilia A Guzei, Samuel H Gellman.

Abstract

We report the development of diacid units that promote formation of a two-stranded parallel beta-sheet secondary structure between peptide segments attached via their N-termini. These linker units are formed by attaching glycine to one carboxyl group of cis-1,2-cyclohexanedicarboxylic acid (CHDA). Parallel sheet formation in water is observed when l-residue strands are attached to the CHDA-Gly unit with either of the two absolute configurations.

Entities: Chemical Gene

Mesh：

Substances：
Acids
Solutions
Water

Year: 2008 PMID： 18507461 PMCID： PMC2689375 DOI： 10.1021/ja802042c

Source DB: PubMed Journal: J Am Chem Soc ISSN： 0002-7863 Impact factor: 15.419

22 in total

1. Dissecting the stability of a beta-hairpin peptide that folds in water: NMR and molecular dynamics analysis of the beta-turn and beta-strand contributions to folding.

Authors: S R Griffiths-Jones; A J Maynard; M S Searle
Journal: J Mol Biol Date: 1999-10-08 Impact factor: 5.469

2. The nucleation of monomeric parallel beta-sheet-like structures and their self-assembly in aqueous solution.

Authors: P Chitnumsub; W R Fiori; H A Lashuel; H Diaz; J W Kelly
Journal: Bioorg Med Chem Date: 1999-01 Impact factor: 3.641

3. Diffusion NMR spectroscopy in supramolecular and combinatorial chemistry: an old parameter--new insights.

Authors: Yoram Cohen; Liat Avram; Limor Frish
Journal: Angew Chem Int Ed Engl Date: 2005-01-14 Impact factor: 15.336

Review 4. Diffusion NMR spectroscopy: folding and aggregation of domains in p53.

Authors: Alexander Dehner; Horst Kessler
Journal: Chembiochem Date: 2005-09 Impact factor: 3.164

5. Thermodynamic analysis of autonomous parallel beta-sheet formation in water.

Authors: John D Fisk; Margaret A Schmitt; Samuel H Gellman
Journal: J Am Chem Soc Date: 2006-06-07 Impact factor: 15.419

6. IR study of cross-strand coupling in a beta-hairpin peptide using isotopic labels.

Authors: Vladimír Setnicka; Rong Huang; Catherine L Thomas; Marcus A Etienne; Jan Kubelka; Robert P Hammer; Timothy A Keiderling
Journal: J Am Chem Soc Date: 2005-04-13 Impact factor: 15.419

7. Crystallography & NMR system: A new software suite for macromolecular structure determination.

Authors: A T Brünger; P D Adams; G M Clore; W L DeLano; P Gros; R W Grosse-Kunstleve; J S Jiang; J Kuszewski; M Nilges; N S Pannu; R J Read; L M Rice; T Simonson; G L Warren
Journal: Acta Crystallogr D Biol Crystallogr Date: 1998-09-01

Review 8. Minimal model systems for beta sheet secondary structure in proteins.

Authors: S H Gellman
Journal: Curr Opin Chem Biol Date: 1998-12 Impact factor: 8.822

9. Intrinsic secondary structure propensities of the amino acids, using statistical phi-psi matrices: comparison with experimental scales.

Authors: V Muñoz; L Serrano
Journal: Proteins Date: 1994-12

7. Improved Stability and Tunable Functionalization of Parallel β-Sheets via Multicomponent N-Alkylation of the Turn Moiety.

Authors: Manuel G Ricardo; Celia G Moya; Carlos S Pérez; Andrea Porzel; Ludger A Wessjohann; Daniel G Rivera
Journal: Angew Chem Int Ed Engl Date: 2019-12-04 Impact factor: 15.336

7 in total

Diacid linkers that promote parallel beta-sheet secondary structure in water.

1. Dissecting the stability of a beta-hairpin peptide that folds in water: NMR and molecular dynamics analysis of the beta-turn and beta-strand contributions to folding.

2. The nucleation of monomeric parallel beta-sheet-like structures and their self-assembly in aqueous solution.

3. Diffusion NMR spectroscopy in supramolecular and combinatorial chemistry: an old parameter--new insights.

Review 4. Diffusion NMR spectroscopy: folding and aggregation of domains in p53.

5. Thermodynamic analysis of autonomous parallel beta-sheet formation in water.

6. IR study of cross-strand coupling in a beta-hairpin peptide using isotopic labels.

7. Crystallography & NMR system: A new software suite for macromolecular structure determination.

Review 8. Minimal model systems for beta sheet secondary structure in proteins.

9. Intrinsic secondary structure propensities of the amino acids, using statistical phi-psi matrices: comparison with experimental scales.

10. Amino acid pairing preferences in parallel beta-sheets in proteins.

1. Structure-Property Relationship Study of N-(Hydroxy)Peptides for the Design of Self-Assembled Parallel β-Sheets.

2. Toward a Soluble Model System for the Amyloid State.

3. Macrocyclic design strategies for small, stable parallel beta-sheet scaffolds.

4. Impact of Strand Number on Parallel β-Sheet Stability.

Review 5. Artificial beta-sheets: chemical models of beta-sheets.

6. Ketoxime peptide ligations: oxidative couplings of alkoxyamines to N-aryl peptides.

7. Improved Stability and Tunable Functionalization of Parallel β-Sheets via Multicomponent N-Alkylation of the Turn Moiety.