| Literature DB >> 18489171 |
I-Hsien Chou1, Melodie Benford, Hope T Beier, Gerard L Coté, Miao Wang, Nan Jing, Jun Kameoka, Theresa A Good.
Abstract
Trace detection of the conformational transition of beta-amyloid peptide (Abeta) from a predominantly alpha-helical structure to beta-sheet could have a large impact in understanding and diagnosing Alzheimer's disease. We demonstrate how a novel nanofluidic biosensor using a controlled, reproducible surface enhanced Raman spectroscopy active site was developed to observe Abeta in different conformational states during the Abeta self-assembly process as well as to distinguish Abeta from confounder proteins commonly found in cerebral spinal fluid.Entities:
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Year: 2008 PMID: 18489171 PMCID: PMC2587305 DOI: 10.1021/nl0808132
Source DB: PubMed Journal: Nano Lett ISSN: 1530-6984 Impact factor: 11.189