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Literature DB >> 21860457

Getting physical to fix pharma.

Patrick R Connelly, T Minh Vuong, Mark A Murcko.

Abstract

Powerful technologies allow the synthesis and testing of large numbers of new compounds, but the failure rate of pharmaceutical R&D remains very high. Greater understanding of the fundamental physical chemical behaviour of molecules could be the key to greatly enhancing the success rate of drug discovery.

Entities: Chemical

Mesh：

Substances：

Year: 2011 PMID： 21860457 DOI： 10.1038/nchem.1121

Source DB: PubMed Journal: Nat Chem ISSN： 1755-4330 Impact factor: 24.427

38 in total

1. A group of thermodynamic potentials applicable to ligand binding by a polyfunctional macromolecule.

Authors: J Wyman
Journal: Proc Natl Acad Sci U S A Date: 1975-04 Impact factor: 11.205

Review 2. Self-assembled multicompartment liquid crystalline lipid carriers for protein, peptide, and nucleic acid drug delivery.

Authors: Angelina Angelova; Borislav Angelov; Rada Mutafchieva; Sylviane Lesieur; Patrick Couvreur
Journal: Acc Chem Res Date: 2010-12-29 Impact factor: 22.384

3. Label-free, single-molecule detection with optical microcavities.

Authors: Andrea M Armani; Rajan P Kulkarni; Scott E Fraser; Richard C Flagan; Kerry J Vahala
Journal: Science Date: 2007-07-05 Impact factor: 47.728

Review 4. Covalent modifiers: an orthogonal approach to drug design.

Authors: Michele H Potashman; Mark E Duggan
Journal: J Med Chem Date: 2009-03-12 Impact factor: 7.446

Review 5. Nanoparticles in biological systems.

Authors: Wendelin J Stark
Journal: Angew Chem Int Ed Engl Date: 2011-01-10 Impact factor: 15.336

6. Protein folding stability and dynamics imaged in a living cell.

Authors: Simon Ebbinghaus; Apratim Dhar; J Douglas McDonald; Martin Gruebele
Journal: Nat Methods Date: 2010-02-28 Impact factor: 28.547

7. A Model-Based Methodology for Spray-Drying Process Development.

Authors: Dan E Dobry; Dana M Settell; John M Baumann; Rod J Ray; Lisa J Graham; Ron A Beyerinck
Journal: J Pharm Innov Date: 2009-07-25 Impact factor: 2.750

8. Coupled energetics of lambda cro repressor self-assembly and site-specific DNA operator binding II: cooperative interactions of cro dimers.

Authors: P J Darling; J M Holt; G K Ackers
Journal: J Mol Biol Date: 2000-09-22 Impact factor: 5.469

9. Structure and dynamics of NBD1 from CFTR characterized using crystallography and hydrogen/deuterium exchange mass spectrometry.

Authors: H A Lewis; C Wang; X Zhao; Y Hamuro; K Conners; M C Kearins; F Lu; J M Sauder; K S Molnar; S J Coales; P C Maloney; W B Guggino; D R Wetmore; P C Weber; J F Hunt
Journal: J Mol Biol Date: 2009-11-26 Impact factor: 5.469

10. Novel mutant-selective EGFR kinase inhibitors against EGFR T790M.

Authors: Wenjun Zhou; Dalia Ercan; Liang Chen; Cai-Hong Yun; Danan Li; Marzia Capelletti; Alexis B Cortot; Lucian Chirieac; Roxana E Iacob; Robert Padera; John R Engen; Kwok-Kin Wong; Michael J Eck; Nathanael S Gray; Pasi A Jänne
Journal: Nature Date: 2009-12-24 Impact factor: 49.962

4 in total

4. A gratuitous β-Lactamase inducer uncovers hidden active site dynamics of the Staphylococcus aureus BlaR1 sensor domain.

Authors: Thomas E Frederick; Jeffrey W Peng
Journal: PLoS One Date: 2018-05-17 Impact factor: 3.240