Literature DB >> 18423417

Peptidomimetics, a synthetic tool of drug discovery.

Josef Vagner1, Hongchang Qu, Victor J Hruby.   

Abstract

The demand for modified peptides with improved stability profiles and pharmacokinetic properties is driving extensive research effort in this field. Many structural modifications of peptides guided by rational design and molecular modeling have been established to develop novel synthetic approaches. Recent advances in the synthesis of conformationally restricted building blocks and peptide bond isosteres are discussed.

Mesh：

Substances：

Year:  2008        PMID： 18423417      PMCID： PMC2515564          DOI： 10.1016/j.cbpa.2008.03.009

Source DB:  PubMed          Journal:  Curr Opin Chem Biol        ISSN： 1367-5931            Impact factor:   8.822


  30 in total

1.  Design of nonpeptides from peptide ligands for peptide receptors.

Authors:  Victor J Hruby; Wei Qui; Toru Okayama; Vadim A Soloshonok
Journal:  Methods Enzymol       Date:  2002       Impact factor: 1.600

Review 2.  Exploring Ramachandran and chi space: conformationally constrained amino acids and peptides in the design of bioactive polypeptide ligands.

Authors:  S M Cowell; Y S Lee; J P Cain; V J Hruby
Journal:  Curr Med Chem       Date:  2004-11       Impact factor: 4.530

3.  Synthesis of constrained analogues of cholecystokinin/opioid chimeric peptides.

Authors:  John M Ndungu; James P Cain; Peg Davis; Shou-W Ma; Todd W Vanderah; Josephine Lai; Frank Porreca; Victor J Hruby
Journal:  Tetrahedron Lett       Date:  2006-03-27       Impact factor: 2.415

4.  A new type of synthetic peptide library for identifying ligand-binding activity.

Authors:  K S Lam; S E Salmon; E M Hersh; V J Hruby; W M Kazmierski; R J Knapp
Journal:  Nature       Date:  1991-11-07       Impact factor: 49.962

Review 5.  Peptidomimetic design.

Authors:  A S Ripka; D H Rich
Journal:  Curr Opin Chem Biol       Date:  1998-08       Impact factor: 8.822

Review 6.  Emerging approaches in the molecular design of receptor-selective peptide ligands: conformational, topographical and dynamic considerations.

Authors:  V J Hruby; F al-Obeidi; W Kazmierski
Journal:  Biochem J       Date:  1990-06-01       Impact factor: 3.857

7.  Design of peptides, proteins, and peptidomimetics in chi space.

Authors:  V J Hruby; G Li; C Haskell-Luevano; M Shenderovich
Journal:  Biopolymers       Date:  1997       Impact factor: 2.505

8.  Optimized selective N-methylation of peptides on solid support.

Authors:  Eric Biron; Jayanta Chatterjee; Horst Kessler
Journal:  J Pept Sci       Date:  2006-03       Impact factor: 1.905

9.  Parallel synthesis and biological evaluation of different sizes of bicyclo[2,3]-Leu-enkephalin analogues.

Authors:  Xuyuan Gu; Jinfa Ying; Byoung Min; James P Cain; Peg Davis; Patrick Willey; Edita Navratilova; Henry I Yamamura; Frank Porreca; Victor J Hruby
Journal:  Biopolymers       Date:  2005       Impact factor: 2.505

10.  Novel design of bicyclic beta-turn dipeptides on solid-phase supports and synthesis of [3.3.0]-Bicyclo([2,3])-leu-enkephalin analogues.

Authors:  Xuyuan Gu; Jinfa Ying; Richard S Agnes; Edita Navratilova; Peg Davis; Gannon Stahl; Frank Porreca; Henry I Yamamura; Victor J Hruby
Journal:  Org Lett       Date:  2004-09-16       Impact factor: 6.005
View more
  80 in total

1.  Limitations of peptide retro-inverso isomerization in molecular mimicry.

Authors:  Chong Li; Marzena Pazgier; Jing Li; Changqing Li; Min Liu; Guozhang Zou; Zhenyu Li; Jiandong Chen; Sergey G Tarasov; Wei-Yue Lu; Wuyuan Lu
Journal:  J Biol Chem       Date:  2010-04-09       Impact factor: 5.157

2.  Chromodomain Ligand Optimization via Target-Class Directed Combinatorial Repurposing.

Authors:  Kimberly D Barnash; Kelsey N Lamb; Jacob I Stuckey; Jacqueline L Norris; Stephanie H Cholensky; Dmitri B Kireev; Stephen V Frye; Lindsey I James
Journal:  ACS Chem Biol       Date:  2016-07-14       Impact factor: 5.100

3.  X-ray structures of endothelin ETB receptor bound to clinical antagonist bosentan and its analog.

Authors:  Wataru Shihoya; Tomohiro Nishizawa; Keitaro Yamashita; Asuka Inoue; Kunio Hirata; Francois Marie Ngako Kadji; Akiko Okuta; Kazutoshi Tani; Junken Aoki; Yoshinori Fujiyoshi; Tomoko Doi; Osamu Nureki
Journal:  Nat Struct Mol Biol       Date:  2017-08-14       Impact factor: 15.369

Review 4.  Classification of scaffold-hopping approaches.

Authors:  Hongmao Sun; Gregory Tawa; Anders Wallqvist
Journal:  Drug Discov Today       Date:  2011-10-26       Impact factor: 7.851

Review 5.  Mechanisms and Strategies Shaping Plant Peptide Hormones.

Authors:  Yuki Hirakawa; Keiko U Torii; Naoyuki Uchida
Journal:  Plant Cell Physiol       Date:  2017-08-01       Impact factor: 4.927

6.  Peptide truncation leads to a twist and an unusual increase in affinity for casitas B-lineage lymphoma tyrosine kinase binding domain.

Authors:  Eric A Kumar; Ziyan Yuan; Nicholas Y Palermo; Lin Dong; Gulzar Ahmad; G L Lokesh; Carol Kolar; Smitha Kizhake; Gloria E O Borgstahl; Hamid Band; Amarnath Natarajan
Journal:  J Med Chem       Date:  2012-03-19       Impact factor: 7.446

7.  Developing potent backbone cyclic peptides bearing the shared epitope sequence as rheumatoid arthritis drug-leads.

Authors:  Shirly Naveh; Yftah Tal-Gan; Song Ling; Amnon Hoffman; Joseph Holoshitz; Chaim Gilon
Journal:  Bioorg Med Chem Lett       Date:  2011-11-04       Impact factor: 2.823

8.  A multicomponent approach to the synthesis of 1,3-dicarbonylic compounds.

Authors:  Ana G Neo; Rosa M Carrillo; Jose Delgado; Stefano Marcaccini; Carlos F Marcos
Journal:  Mol Divers       Date:  2010-09-03       Impact factor: 2.943

Review 9.  Peptides and peptidomimetics as immunomodulators.

Authors:  Ameya S Gokhale; Seetharama Satyanarayanajois
Journal:  Immunotherapy       Date:  2014       Impact factor: 4.196

10.  Potassium (1-methoxy-carbonyl-2-methyl-prop-2-en-2-yl-idene)azinate.

Authors:  Cédric Reuter; Jörg M Neudörfl; Hans-Günther Schmalz
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2010-03-27
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.