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Literature DB >> 9736916

Peptidomimetic design.

Abstract

Major discoveries have been made of new type-I and type-III peptidomimetic inhibitors of peptide-derived systems. Innovative reversible inhibitors of cysteine proteases and renin, and additional examples of peptidomimetic inhibitors of interleukin-1 beta-converting enzyme, neutral endopeptidase, herpes simplex virus protease, thrombin, HIV protease, Ras farnesyltransferase, the RGD motif, Factor Xa and various aspartic proteases have been discovered.

Entities: Gene

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Year: 1998 PMID： 9736916 DOI： 10.1016/s1367-5931(98)80119-1

Source DB: PubMed Journal: Curr Opin Chem Biol ISSN： 1367-5931 Impact factor: 8.822

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Cited

29 in total

1. Design and synthesis of type-III mimetics of ShK toxin.

Authors: Jonathan B Baell; Andrew J Harvey; Raymond S Norton
Journal: J Comput Aided Mol Des Date: 2002-04 Impact factor: 3.686

2. Design and synthesis of type-III mimetics of omega-conotoxin GVIA.

Authors: J B Baell; S A Forsyth; R W Gable; R S Norton; R J Mulder
Journal: J Comput Aided Mol Des Date: 2001-12 Impact factor: 3.686

3. Defining scaffold geometries for interacting with proteins: geometrical classification of secondary structure linking regions.

Authors: Tran T Tran; Christina Kulis; Steven M Long; Darryn Bryant; Peter Adams; Mark L Smythe
Journal: J Comput Aided Mol Des Date: 2010-09-23 Impact factor: 3.686

Peptidomimetic design.

1. Design and synthesis of type-III mimetics of ShK toxin.

2. Design and synthesis of type-III mimetics of omega-conotoxin GVIA.

3. Defining scaffold geometries for interacting with proteins: geometrical classification of secondary structure linking regions.

4. Universal peptidomimetics.

5. Do benzodiazepines mimic reverse-turn structures?

6. Topological side-chain classification of beta-turns: ideal motifs for peptidomimetic development.

Review 7. Peptidomimetics, a synthetic tool of drug discovery.

Review 8. Peptoid drug discovery and optimization via surface X-ray scattering.

Review 9. Discovery of K_V 1.3 ion channel inhibitors: Medicinal chemistry approaches and challenges.

Review 10. Inhibition of α-helix-mediated protein-protein interactions using designed molecules.

Peptidomimetic design.

1. Design and synthesis of type-III mimetics of ShK toxin.

2. Design and synthesis of type-III mimetics of omega-conotoxin GVIA.

3. Defining scaffold geometries for interacting with proteins: geometrical classification of secondary structure linking regions.

4. Universal peptidomimetics.

5. Do benzodiazepines mimic reverse-turn structures?

6. Topological side-chain classification of beta-turns: ideal motifs for peptidomimetic development.

Review 7. Peptidomimetics, a synthetic tool of drug discovery.

Review 8. Peptoid drug discovery and optimization via surface X-ray scattering.

Review 9. Discovery of KV 1.3 ion channel inhibitors: Medicinal chemistry approaches and challenges.

Review 10. Inhibition of α-helix-mediated protein-protein interactions using designed molecules.

Review 9. Discovery of K_V 1.3 ion channel inhibitors: Medicinal chemistry approaches and challenges.