Literature DB >> 18332173

Buthionine sulfoximine has anti-Trypanosoma cruzi activity in a murine model of acute Chagas' disease and enhances the efficacy of nifurtimox.

Mario Faúndez1, Rodrigo López-Muñoz, Gloria Torres, Antonio Morello, Jorge Ferreira, Ulrike Kemmerling, Myriam Orellana, Juan D Maya.   

Abstract

L-buthionine (S,R)-sulfoximine (BSO) at a dose of 220 mg/kg of body weight/day showed an anti-Trypanosoma cruzi effect in infected mice, increasing their survival rate and decreasing the parasitemias and parasite burden in the hearts. Treatment with BSO plus nifurtimox caused an increase in the survival rate in comparison to the rates with treatment with each drug alone.

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Year:  2008        PMID： 18332173      PMCID： PMC2346639          DOI： 10.1128/AAC.01454-07

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  17 in total

Review 1.  A critical review on Chagas disease chemotherapy.

Authors:  José Rodriques Coura; Solange L de Castro
Journal:  Mem Inst Oswaldo Cruz       Date:  2002-01       Impact factor: 2.743

2.  Buthionine sulfoximine increases the toxicity of nifurtimox and benznidazole to Trypanosoma cruzi.

Authors:  Mario Faundez; Laura Pino; Paula Letelier; Carla Ortiz; Rodrigo López; Claudia Seguel; Jorge Ferreira; Mario Pavani; Antonio Morello; Juan Diego Maya
Journal:  Antimicrob Agents Chemother       Date:  2005-01       Impact factor: 5.191

3.  Different behaviors of benznidazole as free radical generator with mammalian and Trypanosoma cruzi microsomal preparations.

Authors:  S N Moreno; R Docampo; R P Mason; W Leon; A O Stoppani
Journal:  Arch Biochem Biophys       Date:  1982-10-15       Impact factor: 4.013

4.  In vivo effects of difluoromethylornithine on trypanothione and polyamine levels in bloodstream forms of Trypanosoma brucei.

Authors:  A H Fairlamb; G B Henderson; C J Bacchi; A Cerami
Journal:  Mol Biochem Parasitol       Date:  1987-06       Impact factor: 1.759

5.  Potent and specific inhibition of glutathione synthesis by buthionine sulfoximine (S-n-butyl homocysteine sulfoximine).

Authors:  O W Griffith; A Meister
Journal:  J Biol Chem       Date:  1979-08-25       Impact factor: 5.157

6.  Thirteenfold increase of chromosomal aberrations non-randomly distributed in chagasic children treated with nifurtimox.

Authors:  N B Gorla; O S Ledesma; G P Barbieri; I B Larripa
Journal:  Mutat Res       Date:  1989-10       Impact factor: 2.433

Review 7.  Free radicals in the physiological control of cell function.

Authors:  Wulf Dröge
Journal:  Physiol Rev       Date:  2002-01       Impact factor: 37.312

Review 8.  Thiol-based redox metabolism of protozoan parasites.

Authors:  Sylke Müller; Eva Liebau; Rolf D Walter; R Luise Krauth-Siegel
Journal:  Trends Parasitol       Date:  2003-07

9.  Activity of megazol, a trypanocidal nitroimidazole, is associated with DNA damage.

Authors:  Bertin Enanga; Mark R Ariyanayagam; Mhairi L Stewart; Michael P Barrett
Journal:  Antimicrob Agents Chemother       Date:  2003-10       Impact factor: 5.191

10.  Inhibition of glutathione synthesis as a chemotherapeutic strategy for trypanosomiasis.

Authors:  B A Arrick; O W Griffith; A Cerami
Journal:  J Exp Med       Date:  1981-03-01       Impact factor: 14.307
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  13 in total

1.  In vitro and in vivo trypanocidal synergistic activity of N-butyl-1-(4-dimethylamino)phenyl-1,2,3,4-tetrahydro-β-carboline-3-carboxamide associated with benznidazole.

Authors:  Rodrigo Hinojosa Valdez; Lilian Tatiani Düsman Tonin; Tânia Ueda-Nakamura; Sueli Oliveira Silva; Benedito Prado Dias Filho; Edilson Nobuyoshi Kaneshima; Sueli Fumie Yamada-Ogatta; Lucy Megumi Yamauchi; Maria Helena Sarragiotto; Celso Vataru Nakamura
Journal:  Antimicrob Agents Chemother       Date:  2011-10-28       Impact factor: 5.191

2.  Protection of vascular endothelium by aspirin in a murine model of chronic Chagas' disease.

Authors:  Alfredo Molina-Berríos; Carolina Campos-Estrada; Michel Lapier; Juan Duaso; Ulrike Kemmerling; Norbel Galanti; Jorge Ferreira; Antonio Morello; Rodrigo López-Muñoz; Juan Diego Maya
Journal:  Parasitol Res       Date:  2013-05-17       Impact factor: 2.289

3.  Trypanosoma cruzi: antiproliferative effect of indole phytoalexins on intracellular amastigotes in vitro.

Authors:  Roman Mezencev; Melina Galizzi; Peter Kutschy; Roberto Docampo
Journal:  Exp Parasitol       Date:  2009-02-01       Impact factor: 2.011

4.  Reorganization of extracellular matrix in placentas from women with asymptomatic chagas disease: mechanism of parasite invasion or local placental defense?

Authors:  Juan Duaso; Erika Yanez; Christian Castillo; Norbel Galanti; Gonzalo Cabrera; Gabriela Corral; Juan Diego Maya; Inés Zulantay; Werner Apt; Ulrike Kemmerling
Journal:  J Trop Med       Date:  2011-10-05

5.  Benznidazole biotransformation and multiple targets in Trypanosoma cruzi revealed by metabolomics.

Authors:  Andrea Trochine; Darren J Creek; Paula Faral-Tello; Michael P Barrett; Carlos Robello
Journal:  PLoS Negl Trop Dis       Date:  2014-05-22

6.  Protective role of acetylsalicylic acid in experimental Trypanosoma cruzi infection: evidence of a 15-epi-lipoxin A₄-mediated effect.

Authors:  Alfredo Molina-Berríos; Carolina Campos-Estrada; Natalia Henriquez; Mario Faúndez; Gloria Torres; Christian Castillo; Sebastián Escanilla; Ulrike Kemmerling; Antonio Morello; Rodrigo A López-Muñoz; Juan D Maya
Journal:  PLoS Negl Trop Dis       Date:  2013-04-18

7.  Benznidazole and posaconazole in experimental Chagas disease: positive interaction in concomitant and sequential treatments.

Authors:  Lívia de Figueiredo Diniz; Julio A Urbina; Isabel Mayer de Andrade; Ana Lia Mazzeti; Tassiane Assíria F Martins; Ivo Santana Caldas; André Talvani; Isabela Ribeiro; Maria Terezinha Bahia
Journal:  PLoS Negl Trop Dis       Date:  2013-08-15

Review 8.  Synthetic Medicinal Chemistry in Chagas' Disease: Compounds at The Final Stage of "Hit-To-Lead" Phase.

Authors:  Hugo Cerecetto; Mercedes González
Journal:  Pharmaceuticals (Basel)       Date:  2010-03-25

9.  Nifurtimox Is Effective Against Neural Tumor Cells and Is Synergistic with Buthionine Sulfoximine.

Authors:  Michael Du; Linna Zhang; Kathleen A Scorsone; Sarah E Woodfield; Peter E Zage
Journal:  Sci Rep       Date:  2016-06-10       Impact factor: 4.379

10.  Dipyridamole potentiated the trypanocidal effect of nifurtimox and improved the cardiac function in NMRI mice with acute chagasic myocarditis.

Authors:  Sonia Santeliz; Peter Caicedo; Elidiosmar Giraldo; Carmen Alvarez; María-Daniela Yustiz; Claudina Rodríguez-Bonfante; Romina Bonfante-Rodríguez; Rafael Bonfante-Cabarcas
Journal:  Mem Inst Oswaldo Cruz       Date:  2017-09       Impact factor: 2.743
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