| Literature DB >> 2507913 |
N B Gorla1, O S Ledesma, G P Barbieri, I B Larripa.
Abstract
Chromosomal aberrations were analyzed from cultures of peripheral lymphocytes in 2 groups of chagasic children, before and after treatment with nifurtimox. The mean incidence of chromosomal aberrations increased from control values of 1.75 +/- 1.39 (8 patients) to 23.55 +/- 9.55 (6 patients) at a significance of P less than 0.0001. G-banding analysis of chromosomal aberration sites revealed that treated patients present coincidence in the chromosome regions affected: 1p11, 1q11-12, 9q11-13, 17q11-21, 2p21, 2q23, 2q31, 2q33, 6p21, 6p21, 7q32, 13q14, 13q22, 15q22. These data indicate a non-random distribution of chromosomal aberrations induced by nifurtimox therapeutic treatment.Entities:
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Year: 1989 PMID： 2507913 DOI： 10.1016/0165-1218(89)90165-1
Source DB: PubMed Journal: Mutat Res ISSN： 0027-5107 Impact factor: 2.433