Literature DB >> 19545522

Trypanosoma cruzi: antiproliferative effect of indole phytoalexins on intracellular amastigotes in vitro.

Roman Mezencev1, Melina Galizzi, Peter Kutschy, Roberto Docampo.   

Abstract

American trypanosomiasis (Chagas disease) continues to be a significant public health problem, and the therapeutic potential of current antichagasic agents (nifurtimox and benznidazole) is rather limited. Here we report on the antitrypanosomal effect of 1-methoxyspirobrassinol and other indole phytoalexins--secondary metabolites produced by Cruciferous plants. These compounds, that previously demonstrated antimicrobial and anticancer properties, displayed significant antiproliferative effects on intracellular amastigotes of Trypanosoma cruzi and may be prospective candidates for antichagasic drug design and development.

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Year:  2009        PMID： 19545522      PMCID： PMC2784243          DOI： 10.1016/j.exppara.2009.01.013

Source DB:  PubMed          Journal:  Exp Parasitol        ISSN： 0014-4894            Impact factor:   2.011


  26 in total

1.  Structure-activity relationship of new growth inhibitors of Trypanosoma cruzi.

Authors:  G M Cinque; S H Szajnman; L Zhong; R Docampo; A J Schvartzapel; J B Rodriguez; E G Gros
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2.  Mode of action of the Arabidopsis thaliana phytoalexin camalexin and its role in Arabidopsis-pathogen interactions.

Authors:  E E Rogers; J Glazebrook; F M Ausubel
Journal:  Mol Plant Microbe Interact       Date:  1996-11       Impact factor: 4.171

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Authors:  B Nadal-Ginard
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5.  Trypanocidal flavonoids from Trixis vauthieri.

Authors:  A Ribeiro; D Piló-Veloso; A J Romanha; C L Zani
Journal:  J Nat Prod       Date:  1997-08       Impact factor: 4.050

Review 6.  Strategies for prevention of transfusion-associated Chagas' disease.

Authors:  H Moraes-Souza; J O Bordin
Journal:  Transfus Med Rev       Date:  1996-07

7.  Synthesis and cytotoxic activity of indolyl thiazoles.

Authors:  C J Moody; J R Roffey; M A Stephens; I J Stratford
Journal:  Anticancer Drugs       Date:  1997-06       Impact factor: 2.248

8.  Anticancer properties of 2-piperidyl analogues of the natural indole phytoalexin 1-methoxyspirobrassinol.

Authors:  Roman Mezencev; Peter Kutschy; Aneta Salayová; Zuzana Curillová; Ján Mojzis; Martina Pilátová; John McDonald
Journal:  Chemotherapy       Date:  2008-09-04       Impact factor: 2.544

9.  A method to assess invasion and intracellular replication of Trypanosoma cruzi based on differential uracil incorporation.

Authors:  W Yan; S N Moreno
Journal:  J Immunol Methods       Date:  1998-11-01       Impact factor: 2.303

10.  Inhibition of glutathione synthesis as a chemotherapeutic strategy for trypanosomiasis.

Authors:  B A Arrick; O W Griffith; A Cerami
Journal:  J Exp Med       Date:  1981-03-01       Impact factor: 14.307
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  11 in total

1.  Effects of ferrofluid and phytoalexin spirobrassinin on thioflavin-T-based fluorescence in cerebrospinal fluid of the elderly and multiple sclerosis patients.

Authors:  Zdena Kristofikova; Zuzana Gazova; Katarina Siposova; Ales Bartos; Jan Ricny; Jolana Kotoucova; Jana Sirova; Daniela Ripova
Journal:  Neurochem Res       Date:  2014-05-25       Impact factor: 3.996

2.  High-content imaging for automated determination of host-cell infection rate by the intracellular parasite Trypanosoma cruzi.

Authors:  L L Nohara; C Lema; J O Bader; R J Aguilera; I C Almeida
Journal:  Parasitol Int       Date:  2010-08-03       Impact factor: 2.230

3.  Organocatalytic enantioselective tandem aldol-cyclization reaction of α-isothiocyanato imides and activated carbonyl compounds.

Authors:  Jie Guang; Cong-Gui Zhao
Journal:  Tetrahedron Asymmetry       Date:  2011-06-15

4.  Camalexin induces apoptosis in T-leukemia Jurkat cells by increased concentration of reactive oxygen species and activation of caspase-8 and caspase-9.

Authors:  Roman Mezencev; Taylor Updegrove; Peter Kutschy; Mária Repovská; John F McDonald
Journal:  J Nat Med       Date:  2011-03-19       Impact factor: 2.343

Review 5.  Synthesis of indole derivatives as prevalent moieties present in selected alkaloids.

Authors:  Majid M Heravi; Zahra Amiri; Kosar Kafshdarzadeh; Vahideh Zadsirjan
Journal:  RSC Adv       Date:  2021-10-15       Impact factor: 4.036

6.  Microsatellite and mini-exon analysis of Mexican human DTU I Trypanosoma cruzi strains and their susceptibility to nifurtimox and benznidazole.

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Journal:  Vector Borne Zoonotic Dis       Date:  2013-02-19       Impact factor: 2.133

7.  The phytoalexin camalexin mediates cytotoxicity towards aggressive prostate cancer cells via reactive oxygen species.

Authors:  Basil A Smith; Corey L Neal; Mahandranauth Chetram; BaoHan Vo; Roman Mezencev; Cimona Hinton; Valerie A Odero-Marah
Journal:  J Nat Med       Date:  2012-11-24       Impact factor: 2.343

8.  Camalexin Induces Apoptosis via the ROS-ER Stress-Mitochondrial Apoptosis Pathway in AML Cells.

Authors:  Yang Yang; Gang Wang; Wenjun Wu; Shunnan Yao; Xiaoyan Han; Donghua He; Jingsong He; Gaofeng Zheng; Yi Zhao; Zhen Cai; Rui Yu
Journal:  Oxid Med Cell Longev       Date:  2018-11-14       Impact factor: 6.543

9.  Responses of the Necrotrophic Fungus Alternaria brassisicola to the Indolic Phytoalexin Brassinin.

Authors:  Guillaume Quang N'Guyen; Roxane Raulo; Antoine Porquier; Beatrice Iacomi; Sandra Pelletier; Jean-Pierre Renou; Nelly Bataillé-Simoneau; Claire Campion; Bruno Hamon; Anthony Kwasiborski; Justine Colou; Abdelilah Benamar; Pietrick Hudhomme; David Macherel; Philippe Simoneau; Thomas Guillemette
Journal:  Front Plant Sci       Date:  2021-01-14       Impact factor: 5.753

10.  Camalexin-induced apoptosis in prostate cancer cells involves alterations of expression and activity of lysosomal protease cathepsin D.

Authors:  Basil Smith; Diandra Randle; Roman Mezencev; LeeShawn Thomas; Cimona Hinton; Valerie Odero-Marah
Journal:  Molecules       Date:  2014-04-02       Impact factor: 4.411
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