Literature DB >> 14506061

Activity of megazol, a trypanocidal nitroimidazole, is associated with DNA damage.

Bertin Enanga1, Mark R Ariyanayagam, Mhairi L Stewart, Michael P Barrett.   

Abstract

DNA damage associated with the trypanocidal activity of megazol [2-amino-5-(1-methyl-5-nitro-2-imidazolyl)-1,3,4-thiadiazole] was shown in experiments in which DNA repair-deficient RAD51(-/-) Trypanosoma brucei mutants were found to be hypersensitive to the drug. Parasites resistant to megazol were selected and showed modest cross-resistance to other trypanocides, although neither drug efflux nor changes to intracellular thiols correlated with resistance.

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Year:  2003        PMID： 14506061      PMCID： PMC201145          DOI： 10.1128/AAC.47.10.3368-3370.2003

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  31 in total

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