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Literature DB >> 18296521

YjgF is required for isoleucine biosynthesis when Salmonella enterica is grown on pyruvate medium.

Melissa R Christopherson¹, G E Schmitz, Diana M Downs.

Abstract

The YjgF/YER057c/UK114 family of proteins is conserved across the three domains of life, yet no biochemical function has been clearly defined for any member of this family. In Salmonella enterica, a deletion of yjgF results in a requirement for isoleucine when the mutant strain is grown in glucose-serine or pyruvate medium. Feedback inhibition of IlvA is required for the curative effect of isoleucine on glucose-serine medium. On pyruvate medium, yjgF mutants are unable to synthesize enough isoleucine for growth. From this study, we conclude that the isoleucine requirement of a yjgF mutant on pyruvate is a consequence of the decreased transaminase B (IlvE) activity that has previously been characterized in these mutants.

Entities: Chemical Gene Species

Mesh：

Substances：

Year: 2008 PMID： 18296521 PMCID： PMC2293226 DOI： 10.1128/JB.01700-07

Source DB: PubMed Journal: J Bacteriol ISSN： 0021-9193 Impact factor: 3.490

43 in total

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