Literature DB >> 20817725

Members of the YjgF/YER057c/UK114 family of proteins inhibit phosphoribosylamine synthesis in vitro.

Jennifer A Lambrecht1, Beth Ann Browne, Diana M Downs.   

Abstract

The YjgF/YER057c/UK114 family of proteins is highly conserved across all three domains of life and currently lacks a consensus biochemical function. Analysis of Salmonella enterica strains lacking yjgF has led to a working model in which YjgF functions to remove potentially toxic secondary products of cellular enzymes. Strains lacking yjgF synthesize the thiamine precursor phosphoribosylamine (PRA) by a TrpD-dependent mechanism that is not present in wild-type strains. Here, PRA synthesis was reconstituted in vitro with anthranilate phosphoribosyltransferase (TrpD), threonine dehydratase (IlvA), threonine, and phosphoribosyl pyrophosphate. TrpD-dependent PRA formation in vitro was inhibited by S. enterica YjgF and the human homolog UK114. Thus, the work herein describes the first biochemical assay for diverse members of the highly conserved YjgF/YER057c/UK114 family of proteins and provides a means to dissect the cellular functions of these proteins.

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Year:  2010        PMID： 20817725      PMCID： PMC2966054          DOI： 10.1074/jbc.M110.160515

Source DB:  PubMed          Journal:  J Biol Chem        ISSN： 0021-9258            Impact factor:   5.157


  40 in total

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2.  One-step inactivation of chromosomal genes in Escherichia coli K-12 using PCR products.

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Journal:  Proc Natl Acad Sci U S A       Date:  2000-06-06       Impact factor: 11.205

3.  The anthranilate synthetase-anthranilate 5-phosphoribosylpyrophosphate phosphoribosyltransferase aggregate. Purification of the aggregate and regulatory properties of anthranilate synthetase.

Authors:  E J Henderson; H Nagano; H Zalkin; L H Hwang
Journal:  J Biol Chem       Date:  1970-03-25       Impact factor: 5.157

4.  A multifunctional enzyme complex in the tryptophan pathway of Salmonella typhimurium: comparison of polarity and pseudopolarity mutations.

Authors:  R H Bauerle; P Margolin
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6.  The mechanism of action of 5'-adenylic acid-activated threonine dehydrase.

Authors:  A T Phillips; W A Wood
Journal:  J Biol Chem       Date:  1965-12       Impact factor: 5.157

7.  Mmf1p, a novel yeast mitochondrial protein conserved throughout evolution and involved in maintenance of the mitochondrial genome.

Authors:  E Oxelmark; A Marchini; I Malanchi; F Magherini; L Jaquet; M A Hajibagheri; K J Blight; J C Jauniaux; M Tommasino
Journal:  Mol Cell Biol       Date:  2000-10       Impact factor: 4.272

8.  Precursors of the pyrimidine moiety of thiamine.

Authors:  P C Newell; R G Tucker
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9.  Solution structure and functional ligand screening of HI0719, a highly conserved protein from bacteria to humans in the YjgF/YER057c/UK114 family.

Authors:  Lisa Parsons; Nicklas Bonander; Edward Eisenstein; Michael Gilson; Visvaldas Kairys; John Orban
Journal:  Biochemistry       Date:  2003-01-14       Impact factor: 3.162

10.  Anthranilate synthase can generate sufficient phosphoribosyl amine for thiamine synthesis in Salmonella enterica.

Authors:  I Ramos; Diana M Downs
Journal:  J Bacteriol       Date:  2003-09       Impact factor: 3.490
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  24 in total

1.  Conserved YjgF protein family deaminates reactive enamine/imine intermediates of pyridoxal 5'-phosphate (PLP)-dependent enzyme reactions.

Authors:  Jennifer A Lambrecht; Jeffrey M Flynn; Diana M Downs
Journal:  J Biol Chem       Date:  2011-11-17       Impact factor: 5.157

Review 2.  RidA Proteins Protect against Metabolic Damage by Reactive Intermediates.

Authors:  Jessica L Irons; Kelsey Hodge-Hanson; Diana M Downs
Journal:  Microbiol Mol Biol Rev       Date:  2020-07-15       Impact factor: 11.056

3.  Der f 34, a Novel Major House Dust Mite Allergen Belonging to a Highly Conserved Rid/YjgF/YER057c/UK114 Family of Imine Deaminases.

Authors:  Kareem Gamal ElRamlawy; Takashi Fujimura; Koji Baba; Ji Won Kim; Chika Kawamoto; Toshihide Isobe; Takuya Abe; Kelsey Hodge-Hanson; Diana M Downs; Inas Hussein Refaat; Diaa Beshr Al-Azhary; Tsunehiro Aki; Yoshiko Asaoku; Takaharu Hayashi; Takashi Katsutani; Shinji Tsuboi; Kazuhisa Ono; Seiji Kawamoto
Journal:  J Biol Chem       Date:  2016-08-18       Impact factor: 5.157

Review 4.  From microbiology to cancer biology: the Rid protein family prevents cellular damage caused by endogenously generated reactive nitrogen species.

Authors:  Diana M Downs; Dustin C Ernst
Journal:  Mol Microbiol       Date:  2015-02-26       Impact factor: 3.501

5.  Structure of Escherichia coli RutC, a member of the YjgF family and putative aminoacrylate peracid reductase of the rut operon.

Authors:  Aleksandra Alicja Knapik; Janusz Jurand Petkowski; Zbyszek Otwinowski; Marcin Tadeusz Cymborowski; David Robert Cooper; Maksymilian Chruszcz; Wanda Małgorzata Krajewska; Wladek Minor
Journal:  Acta Crystallogr Sect F Struct Biol Cryst Commun       Date:  2012-10-26

6.  Plasticity in the purine-thiamine metabolic network of Salmonella.

Authors:  Jannell V Bazurto; Diana M Downs
Journal:  Genetics       Date:  2010-12-06       Impact factor: 4.562

7.  In the absence of RidA, endogenous 2-aminoacrylate inactivates alanine racemases by modifying the pyridoxal 5'-phosphate cofactor.

Authors:  Jeffrey M Flynn; Diana M Downs
Journal:  J Bacteriol       Date:  2013-06-07       Impact factor: 3.490

8.  Analyses of variants of the Ser/Thr dehydratase IlvA provide insight into 2-aminoacrylate metabolism in Salmonella enterica.

Authors:  Andrew J Borchert; Diana M Downs
Journal:  J Biol Chem       Date:  2018-10-16       Impact factor: 5.157

9.  Anthranilate phosphoribosyl transferase (TrpD) generates phosphoribosylamine for thiamine synthesis from enamines and phosphoribosyl pyrophosphate.

Authors:  Jennifer A Lambrecht; Diana M Downs
Journal:  ACS Chem Biol       Date:  2012-11-02       Impact factor: 5.100

10.  Endogenous synthesis of 2-aminoacrylate contributes to cysteine sensitivity in Salmonella enterica.

Authors:  Dustin C Ernst; Jennifer A Lambrecht; Rebecca A Schomer; Diana M Downs
Journal:  J Bacteriol       Date:  2014-07-07       Impact factor: 3.490
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