Literature DB >> 18283614

Isolation and characterization of new Cannabis constituents from a high potency variety.

Mohamed M Radwan1, Samir A Ross, Desmond Slade, Safwat A Ahmed, Fazila Zulfiqar, Mahmoud A Elsohly.   

Abstract

Phytochemical investigation of a high potency variety of Cannabis sativa L. resulted in the isolation of six new metabolites, (+/-)-6,7-trans-epoxycannabigerolic acid ( 2), (+/-)-6,7- CIS-epoxycannabigerolic acid ( 3), (+/-)-6,7- CIS-epoxycannabigerol ( 4), (+/-)-6,7-trans-epoxycannabigerol ( 5), 5'-methyl-4-pentylbiphenyl-2,2',6-triol ( 7), and 7-methoxycannabispirone ( 8), along with seven known compounds namely, cannabigerolic acid ( 1), 5'-methoxycannabigerolic acid ( 6), cannabispirone ( 9), beta-cannabispiranol ( 10), dehydrocannabifuran ( 11), cannflavin B ( 12) and cannabigerol ( 13). The antimicrobial as well as the antileishmanial activities were investigated.

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Year:  2008        PMID： 18283614      PMCID： PMC4887452          DOI： 10.1055/s-2008-1034311

Source DB:  PubMed          Journal:  Planta Med        ISSN： 0032-0943            Impact factor:   3.352


  8 in total

1.  beta-Cannabispiranol: a new non-cannabinoid phenol from Cannabis sativa L.

Authors:  E G Boeren; M A Elsohly; C E Turner; C A Salemink
Journal:  Experientia       Date:  1977-07-15

Review 2.  Cannabinoids in clinical practice.

Authors:  E M Williamson; F J Evans
Journal:  Drugs       Date:  2000-12       Impact factor: 9.546

3.  NMR assignments of the major cannabinoids and cannabiflavonoids isolated from flowers of Cannabis sativa.

Authors:  Young Hae Choi; Arno Hazekamp; Anja M G Peltenburg-Looman; Michel Frédérich; Cornelis Erkelens; Alfons W M Lefeber; Robert Verpoorte
Journal:  Phytochem Anal       Date:  2004 Nov-Dec       Impact factor: 3.373

4.  Potency trends of delta9-THC and other cannabinoids in confiscated marijuana from 1980-1997.

Authors:  M A ElSohly; S A Ross; Z Mehmedic; R Arafat; B Yi; B F Banahan
Journal:  J Forensic Sci       Date:  2000-01       Impact factor: 1.832

5.  Antifungal activity of C-27 steroidal saponins.

Authors:  Chong-Ren Yang; Ying Zhang; Melissa R Jacob; Shabana I Khan; Ying-Jun Zhang; Xing-Cong Li
Journal:  Antimicrob Agents Chemother       Date:  2006-05       Impact factor: 5.191

6.  Hashish. IV. The isolation and structure of cannabinolic cannabidiolic and cannabigerolic acids.

Authors:  R Mechoulam; Y Gaoni
Journal:  Tetrahedron       Date:  1965-05       Impact factor: 2.457

Review 7.  Chemical constituents of marijuana: the complex mixture of natural cannabinoids.

Authors:  Mahmoud A Elsohly; Desmond Slade
Journal:  Life Sci       Date:  2005-09-30       Impact factor: 5.037

8.  Antiprotozoal and antimicrobial activities of O-alkylated and formylated acylphloroglucinols.

Authors:  Sandip B Bharate; Shabana I Khan; Nafees A M Yunus; Siddheshwar K Chauthe; Melissa R Jacob; Babu L Tekwani; Ikhlas A Khan; Inder Pal Singh
Journal:  Bioorg Med Chem       Date:  2006-10-10       Impact factor: 3.641
  8 in total
  21 in total

1.  Antidepressant-like effect of delta9-tetrahydrocannabinol and other cannabinoids isolated from Cannabis sativa L.

Authors:  Abir T El-Alfy; Kelly Ivey; Keisha Robinson; Safwat Ahmed; Mohamed Radwan; Desmond Slade; Ikhlas Khan; Mahmoud ElSohly; Samir Ross
Journal:  Pharmacol Biochem Behav       Date:  2010-03-21       Impact factor: 3.533

2.  Isolation and Pharmacological Evaluation of Minor Cannabinoids from High-Potency Cannabis sativa.

Authors:  Mohamed M Radwan; Mahmoud A ElSohly; Abir T El-Alfy; Safwat A Ahmed; Desmond Slade; Afeef S Husni; Susan P Manly; Lisa Wilson; Suzanne Seale; Stephen J Cutler; Samir A Ross
Journal:  J Nat Prod       Date:  2015-05-22       Impact factor: 4.050

Review 3.  Cannabinoid receptors: nomenclature and pharmacological principles.

Authors:  Linda Console-Bram; Jahan Marcu; Mary E Abood
Journal:  Prog Neuropsychopharmacol Biol Psychiatry       Date:  2012-02-28       Impact factor: 5.067

4.  Neural correlates of interactions between cannabidiol and Δ(9) -tetrahydrocannabinol in mice: implications for medical cannabis.

Authors:  S M Todd; J C Arnold
Journal:  Br J Pharmacol       Date:  2015-11-18       Impact factor: 8.739

5.  Sepicanin A- A new geranyl flavanone from Artocarpus sepicanus with activity against methicillin-resistant Staphylococcus aureus (MRSA).

Authors:  Mohamed M Radwan; Raquel Rodriguez-Guzman; Susan P Manly; Melissa Jacob; Samir A Ross
Journal:  Phytochem Lett       Date:  2009-05-03       Impact factor: 1.679

6.  Microbial metabolism of cannflavin A and B isolated from Cannabis sativa.

Authors:  Amany K Ibrahim; Mohamed M Radwan; Safwat A Ahmed; Desmond Slade; Samir A Ross; Mahmoud A ElSohly; Ikhlas A Khan
Journal:  Phytochemistry       Date:  2010-03-10       Impact factor: 4.072

7.  Disposition of cannabichromene, cannabidiol, and Δ⁹-tetrahydrocannabinol and its metabolites in mouse brain following marijuana inhalation determined by high-performance liquid chromatography-tandem mass spectrometry.

Authors:  Justin L Poklis; Candace C Thompson; Kelly A Long; Aron H Lichtman; Alphonse Poklis
Journal:  J Anal Toxicol       Date:  2010-10       Impact factor: 3.367

8.  Minor oxygenated cannabinoids from high potency Cannabis sativa L.

Authors:  Safwat A Ahmed; Samir A Ross; Desmond Slade; Mohamed M Radwan; Ikhlas A Khan; Mahmoud A ElSohly
Journal:  Phytochemistry       Date:  2015-06-17       Impact factor: 4.072

9.  Structure determination and absolute configuration of cannabichromanone derivatives from high potency Cannabis sativa.

Authors:  Safwat A Ahmed; Samir A Ross; Desmond Slade; Mohamed M Radwan; Ikhlas A Khan; Mahmoud A Elsohly
Journal:  Tetrahedron Lett       Date:  2008-10-13       Impact factor: 2.415

10.  Biologically active cannabinoids from high-potency Cannabis sativa.

Authors:  Mohamed M Radwan; Mahmoud A Elsohly; Desmond Slade; Safwat A Ahmed; Ikhlas A Khan; Samir A Ross
Journal:  J Nat Prod       Date:  2009-05-22       Impact factor: 4.050
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