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Literature DB >> 20223485

Microbial metabolism of cannflavin A and B isolated from Cannabis sativa.

Amany K Ibrahim¹, Mohamed M Radwan, Safwat A Ahmed, Desmond Slade, Samir A Ross, Mahmoud A ElSohly, Ikhlas A Khan.

Abstract

Microbial metabolism of cannflavin A (1) and B (2), two biologically active flavonoids isolated from Cannabis sativa L., produced five metabolites (3-7). Incubation of 1 and 2 with Mucor ramannianus (ATCC 9628) and Beauveria bassiana (ATCC 13144), respectively, yielded 6''S,7''-dihydroxycannflavin A (3), 6''S,7''-dihydroxycannflavin A 7-sulfate (4) and 6''S,7''-dihydroxycannflavin A 4'-O-alpha-L-rhamnopyranoside (5), and cannflavin B 7-O-beta-D-4'''-O-methylglucopyranoside (6) and cannflavin B 7-sulfate (7), respectively. All compounds were evaluated for antimicrobial and antiprotozoal activity. Copyright 2010. Published by Elsevier Ltd.

Entities: Chemical Disease Species

Mesh：

Substances：

Year: 2010 PMID： 20223485 PMCID： PMC4885748 DOI： 10.1016/j.phytochem.2010.02.011

Source DB: PubMed Journal: Phytochemistry ISSN： 0031-9422 Impact factor: 4.072

24 in total

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