Nine new cannabinoids (1-9) were isolated from a high-potency variety of Cannabis sativa. Their structures were identified as (+/-)-4-acetoxycannabichromene (1), (+/-)-3''-hydroxy-Delta((4'',5''))-cannabichromene (2), (-)-7-hydroxycannabichromane (3), (-)-7R-cannabicoumarononic acid A (4), 5-acetyl-4-hydroxycannabigerol (5), 4-acetoxy-2-geranyl-5-hydroxy-3-n-pentylphenol (6), 8-hydroxycannabinol (7), 8-hydroxycannabinolic acid A (8), and 2-geranyl-5-hydroxy-3-n-pentyl-1,4-benzoquinone (9) through 1D and 2D NMR spectroscopy, GC-MS, and HRESIMS. The known sterol beta-sitosterol-3-O-beta-d-glucopyranosyl-6'-acetate was isolated for the first time from cannabis. Compounds 6 and 7 displayed significant antibacterial and antifungal activities, respectively, while 5 displayed strong antileishmanial activity.
Nine new n class="Chemical">cannabinoids (1-9) were isolated from a high-potency variety of Cannabis sativa. Their structures were identified as (+/-)-4-acetoxycannabichromene (1), (+/-)-3''-hydroxy-Delta((4'',5''))-cannabichromene (2), (-)-7-hydroxycannabichromane (3), (-)-7R-cannabicoumarononic acid A (4), 5-acetyl-4-hydroxycannabigerol (5), 4-acetoxy-2-geranyl-5-hydroxy-3-n-pentylphenol (6), 8-hydroxycannabinol (7), 8-hydroxycannabinolic acid A (8), and 2-geranyl-5-hydroxy-3-n-pentyl-1,4-benzoquinone (9) through 1D and 2DNMR spectroscopy, GC-MS, and HRESIMS. The known sterol beta-sitosterol-3-O-beta-d-glucopyranosyl-6'-acetate was isolated for the first time from cannabis. Compounds 6 and 7 displayed significant antibacterial and antifungal activities, respectively, while 5 displayed strong antileishmanial activity.
Authors: Young Hae Choi; Arno Hazekamp; Anja M G Peltenburg-Looman; Michel Frédérich; Cornelis Erkelens; Alfons W M Lefeber; Robert Verpoorte Journal: Phytochem Anal Date: 2004 Nov-Dec Impact factor: 3.373
Authors: Sandip B Bharate; Shabana I Khan; Nafees A M Yunus; Siddheshwar K Chauthe; Melissa R Jacob; Babu L Tekwani; Ikhlas A Khan; Inder Pal Singh Journal: Bioorg Med Chem Date: 2006-10-10 Impact factor: 3.641
Authors: Mohamed M Radwan; Samir A Ross; Desmond Slade; Safwat A Ahmed; Fazila Zulfiqar; Mahmoud A Elsohly Journal: Planta Med Date: 2008-02-18 Impact factor: 3.352
Authors: Safwat A Ahmed; Samir A Ross; Desmond Slade; Mohamed M Radwan; Ikhlas A Khan; Mahmoud A Elsohly Journal: Tetrahedron Lett Date: 2008-10-13 Impact factor: 2.415
Authors: Safwat A Ahmed; Samir A Ross; Desmond Slade; Mohamed M Radwan; Fazila Zulfiqar; Rae R Matsumoto; Yan-Tong Xu; Eddy Viard; Robert C Speth; Vardan T Karamyan; M A ElSohly Journal: J Nat Prod Date: 2008-02-28 Impact factor: 4.050
Authors: Mohamed M Radwan; Mahmoud A Elsohly; Desmond Slade; Safwat A Ahmed; Lisa Wilson; Abir T El-Alfy; Ikhlas A Khan; Samir A Ross Journal: Phytochemistry Date: 2008-09-04 Impact factor: 4.072
Authors: Mohamed M Radwan; Mahmoud A ElSohly; Abir T El-Alfy; Safwat A Ahmed; Desmond Slade; Afeef S Husni; Susan P Manly; Lisa Wilson; Suzanne Seale; Stephen J Cutler; Samir A Ross Journal: J Nat Prod Date: 2015-05-22 Impact factor: 4.050
Authors: Amany K Ibrahim; Mohamed M Radwan; Safwat A Ahmed; Desmond Slade; Samir A Ross; Mahmoud A ElSohly; Ikhlas A Khan Journal: Phytochemistry Date: 2010-03-10 Impact factor: 4.072
Authors: Mostafa A Elhendawy; Amira S Wanas; Mohamed M Radwan; Nabil A Azzaz; ElShahat S Toson; Mahmoud A ElSohly Journal: Med Cannabis Cannabinoids Date: 2018-12-04
Authors: Fazila Zulfiqar; Samir A Ross; Desmond Slade; Safwat A Ahmed; Mohamed M Radwan; Zulfiqar Ali; Ikhlas A Khan; Mahmoud A ElSohly Journal: Tetrahedron Lett Date: 2012-05-07 Impact factor: 2.415
Authors: Mehrak Javadi-Paydar; Jacques D Nguyen; Tony M Kerr; Yanabel Grant; Sophia A Vandewater; Maury Cole; Michael A Taffe Journal: Psychopharmacology (Berl) Date: 2018-06-16 Impact factor: 4.530