Literature DB >> 27594928

Sepicanin A- A new geranyl flavanone from Artocarpus sepicanus with activity against methicillin-resistant Staphylococcus aureus (MRSA).

Mohamed M Radwan1, Raquel Rodriguez-Guzman2, Susan P Manly1, Melissa Jacob1, Samir A Ross3.   

Abstract

Bioassay-guided fractionation of the EtOH extract of Artocarpus sepicanus Diels leaves has led to the isolation of a new geranyl flavanone (1), along with the known compounds, afzelechin-3-O-α-L-rhamnopyranoside and β-sitosterol glucoside. The structure of the new compound was established by UV, IR, HRESIMS, 1D and 2D NMR experiments. Antimicrobial testing of the three compounds indicated that 1 displayed a significant selective antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA) with IC50 and MIC values of 1.4 and 2.9 μM, respectively.

Entities:  

Keywords:  Artocarpus sepicanus; Flavanone; Methicillin-resistant Staphylococcus aureus; antibacterial

Year:  2009        PMID： 27594928      PMCID： PMC5007001          DOI： 10.1016/j.phytol.2009.04.002

Source DB:  PubMed          Journal:  Phytochem Lett        ISSN： 1874-3900            Impact factor:   1.679


  16 in total

1.  A new dimeric stilbene with tyrosinase inhibitiory activity from Artocarpus gomezianus.

Authors:  K Likhitwitayawuid; B Sritularak
Journal:  J Nat Prod       Date:  2001-11       Impact factor: 4.050

2.  A geranylated chalcone with 5alpha-reductase inhibitory properties from Artocarpus incisus.

Authors:  K Shimiz; R Kondo; K Sakai; S Buabarn; U Dilokkunanant
Journal:  Phytochemistry       Date:  2000-08       Impact factor: 4.072

3.  Sorocenols G and H, anti-MRSA oxygen heterocyclic Diels-Alder-type adducts from Sorocea muriculata roots.

Authors:  Samir A Ross; Raquel Rodríguez-Guzmán; Mohamed M Radwan; Melissa Jacob; Yuanqing Ding; Xing-Cong Li; Daneel Ferreira; Susan P Manly
Journal:  J Nat Prod       Date:  2008-10-11       Impact factor: 4.050

4.  Cytotoxic prenylflavonoids from Artocarpus elasticus.

Authors:  Horng-Huey Ko; Yi-Huang Lu; Sheng-Zehn Yang; Shen-Jeu Won; Chun-Nan Lin
Journal:  J Nat Prod       Date:  2005-11       Impact factor: 4.050

5.  Inhibition of adenosine 3',5'-cyclic monophosphate phosphodiesterase by components of Sophora flavescens Aiton.

Authors:  T Ohmoto; R Aikawa; T Nikaido; U Sankawa; L J Wu; A Ueno; S Fukushima
Journal:  Chem Pharm Bull (Tokyo)       Date:  1986-05       Impact factor: 1.645

6.  Antiinflammatory flavonoids from Artocarpus heterophyllus and Artocarpus communis.

Authors:  Bai-Luh Wei; Jing-Ru Weng; Pao-Hui Chiu; Chi-Feng Hung; Jih-Pyang Wang; Chun-Nan Lin
Journal:  J Agric Food Chem       Date:  2005-05-18       Impact factor: 5.279

7.  Constituents of the bark and twigs of Artocarpus dadah with cyclooxygenase inhibitory activity.

Authors:  Bao-Ning Su; Muriel Cuendet; Michael E Hawthorne; Leonardus B S Kardono; Soedarsono Riswan; Harry H S Fong; Rajendra G Mehta; John M Pezzuto; A Douglas Kinghorn
Journal:  J Nat Prod       Date:  2002-02       Impact factor: 4.050

8.  Artoindonesianin P, a new prenylated flavone with cytotoxic activity from Artocarpus lanceifolius.

Authors:  Euis Holisotan Hakim; Norio Aimi; Mariko Kitajima; Hiromitsu Takayama
Journal:  Fitoterapia       Date:  2002-12       Impact factor: 2.882

9.  Artoindonesianins N and O, new prenylated stilbene and prenylated arylbenzofuran derivatives from Artocarpus gomezianus.

Authors:  Euis Holisotan Hakim; Unsiyah Zulfa Ulinnuha; Yana Maolana Syah; Emilio L Ghisalberti
Journal:  Fitoterapia       Date:  2002-12       Impact factor: 2.882

10.  Geranyl chalcone derivatives with antifungal and radical scavenging properties from the leaves of Artocarpus nobilis.

Authors:  Lalith Jayasinghe; B A I S Balasooriya; W Chintha Padmini; Noriyuki Hara; Yoshinori Fujimoto
Journal:  Phytochemistry       Date:  2004-05       Impact factor: 4.072
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  4 in total

1.  Nigrosphaerin A a new isochromene derivative from the endophytic fungus Nigrospora sphaerica.

Authors:  Ahmed M Metwaly; Hazem A Kadry; Atef A El-Hela; Abd-Elsalam I Mohammad; Guoyi Ma; Stephen J Cutler; Samir A Ross
Journal:  Phytochem Lett       Date:  2013-10-01       Impact factor: 1.679

Review 2.  Prenylated Flavonoids in Topical Infections and Wound Healing.

Authors:  Alice Sychrová; Gabriela Škovranová; Marie Čulenová; Silvia Bittner Fialová
Journal:  Molecules       Date:  2022-07-13       Impact factor: 4.927

3.  Antibacterial and antioxidant activities of derriobtusone A isolated from Lonchocarpus obtusus.

Authors:  Mayron Alves Vasconcelos; Francisco Vassiliepe Sousa Arruda; Daniel Barroso de Alencar; Silvana Saker-Sampaio; Maria Rose Jane Ribeiro Albuquerque; Hélcio Silva Dos Santos; Paulo Nogueira Bandeira; Otília Deusdênia Loiola Pessoa; Benildo Sousa Cavada; Mariana Henriques; Maria Olivia Pereira; Edson Holanda Teixeira
Journal:  Biomed Res Int       Date:  2014-06-01       Impact factor: 3.411

4.  New thiophene and flavonoid from Tagetes minuta leaves growing in Saudi Arabia.

Authors:  Nawal M Al-Musayeib; Gamal A Mohamed; Sabrin R M Ibrahim; Samir A Ross
Journal:  Molecules       Date:  2014-03-04       Impact factor: 4.411
  4 in total

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