Literature DB >> 18212098

Linezolid resistance in Staphylococcus aureus: gene dosage effect, stability, fitness costs, and cross-resistances.

Silke Besier1, Albrecht Ludwig, Johannes Zander, Volker Brade, Thomas A Wichelhaus.   

Abstract

Linezolid resistance in Staphylococcus aureus is typically associated with mutations in the 23S rRNA gene. Here we show that the accumulation of a single point mutation, G2576T, in the different copies of this gene causes stepwise increases in resistance, impairment of the biological fitness, and cross-resistance to quinupristin-dalfopristin and chloramphenicol.

Entities:  

Mesh：

Substances：

Year:  2008        PMID： 18212098      PMCID： PMC2292563          DOI： 10.1128/AAC.01098-07

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  20 in total

1.  Clonal heterogeneity, distribution, and pathogenicity of methicillin-resistant Staphylococcus aureus.

Authors:  T A Wichelhaus; J Schulze; K P Hunfeld; V Schäfer; V Brade
Journal:  Eur J Clin Microbiol Infect Dis       Date:  1997-12       Impact factor: 3.267

2.  Compensatory adaptation to the loss of biological fitness associated with acquisition of fusidic acid resistance in Staphylococcus aureus.

Authors:  Silke Besier; Albrecht Ludwig; Volker Brade; Thomas A Wichelhaus
Journal:  Antimicrob Agents Chemother       Date:  2005-04       Impact factor: 5.191

3.  The site of action of oxazolidinone antibiotics in living bacteria and in human mitochondria.

Authors:  Karen L Leach; Steven M Swaney; Jerry R Colca; William G McDonald; James R Blinn; Lisa M Thomasco; Robert C Gadwood; Dean Shinabarger; Liqun Xiong; Alexander S Mankin
Journal:  Mol Cell       Date:  2007-05-11       Impact factor: 17.970

4.  The oxazolidinone linezolid inhibits initiation of protein synthesis in bacteria.

Authors:  S M Swaney; H Aoki; M C Ganoza; D L Shinabarger
Journal:  Antimicrob Agents Chemother       Date:  1998-12       Impact factor: 5.191

5.  Use of pyrosequencing to identify point mutations in domain V of 23S rRNA genes of linezolid-resistant Staphylococcus aureus and Staphylococcus epidermidis.

Authors:  W Zhu; F C Tenover; J Limor; D Lonsway; D Prince; W M Dunne; J B Patel
Journal:  Eur J Clin Microbiol Infect Dis       Date:  2007-03       Impact factor: 3.267

Review 6.  An infection with linezolid-resistant S. aureus in a patient with left ventricular assist system.

Authors:  Axel Kola; Philip Kirschner; Bernhard Gohrbandt; Iris F Chaberny; Frauke Mattner; Martin Strüber; Petra Gastmeier; Sebastian Suerbaum
Journal:  Scand J Infect Dis       Date:  2007

7.  Acquisition of a natural resistance gene renders a clinical strain of methicillin-resistant Staphylococcus aureus resistant to the synthetic antibiotic linezolid.

Authors:  Seok-Ming Toh; Liqun Xiong; Cesar A Arias; Maria V Villegas; Karen Lolans; John Quinn; Alexander S Mankin
Journal:  Mol Microbiol       Date:  2007-06       Impact factor: 3.501

8.  Persistence of rRNA operon mutated copies and rapid re-emergence of linezolid resistance in Staphylococcus aureus.

Authors:  Athanassios Tsakris; Satish K Pillai; Howard S Gold; Claudie Thauvin-Eliopoulos; Lata Venkataraman; Christine Wennersten; Robert C Moellering; George M Eliopoulos
Journal:  J Antimicrob Chemother       Date:  2007-07-10       Impact factor: 5.790

9.  Emergence of linezolid-resistant Staphylococcus aureus during treatment of pulmonary infection in a patient with cystic fibrosis.

Authors:  Ana C Gales; Hélio S Sader; Soraya S Andrade; Larissa Lutz; Adão Machado; Afonso L Barth
Journal:  Int J Antimicrob Agents       Date:  2006-03-09       Impact factor: 5.283

10.  Alterations at the peptidyl transferase centre of the ribosome induced by the synergistic action of the streptogramins dalfopristin and quinupristin.

Authors:  Jörg M Harms; Frank Schlünzen; Paola Fucini; Heike Bartels; Ada Yonath
Journal:  BMC Biol       Date:  2004-04-01       Impact factor: 7.431
View more
  48 in total

Review 1.  Resistance to linezolid caused by modifications at its binding site on the ribosome.

Authors:  Katherine S Long; Birte Vester
Journal:  Antimicrob Agents Chemother       Date:  2011-12-05       Impact factor: 5.191

Review 2.  Antimicrobial susceptibility testing, drug resistance mechanisms, and therapy of infections with nontuberculous mycobacteria.

Authors:  Barbara A Brown-Elliott; Kevin A Nash; Richard J Wallace
Journal:  Clin Microbiol Rev       Date:  2012-07       Impact factor: 26.132

3.  Emergence of linezolid-resistant mutants in a susceptible-cell population of methicillin-resistant Staphylococcus aureus.

Authors:  Yurika Ikeda-Dantsuji; Hideaki Hanaki; Taiji Nakae; Yoshio Takesue; Kazunori Tomono; Junichi Honda; Katsunori Yanagihara; Hiroshige Mikamo; Kunihiko Fukuchi; Mitsuo Kaku; Shigeru Kohno; Yoshihito Niki
Journal:  Antimicrob Agents Chemother       Date:  2011-02-28       Impact factor: 5.191

4.  Mechanisms of linezolid resistance among Staphylococci in a tertiary hospital.

Authors:  Inmaculada Quiles-Melero; Rosa Gómez-Gil; María Pilar Romero-Gómez; Ana María Sánchez-Díaz; Manuela de Pablos; Julio García-Rodriguez; Avelino Gutiérrez; Jesús Mingorance
Journal:  J Clin Microbiol       Date:  2012-12-26       Impact factor: 5.948

Review 5.  Antimicrobial resistance and virulence: a successful or deleterious association in the bacterial world?

Authors:  Alejandro Beceiro; María Tomás; Germán Bou
Journal:  Clin Microbiol Rev       Date:  2013-04       Impact factor: 26.132

6.  Structural insights into species-specific features of the ribosome from the pathogen Staphylococcus aureus.

Authors:  Zohar Eyal; Donna Matzov; Miri Krupkin; Itai Wekselman; Susanne Paukner; Ella Zimmerman; Haim Rozenberg; Anat Bashan; Ada Yonath
Journal:  Proc Natl Acad Sci U S A       Date:  2015-10-13       Impact factor: 11.205

7.  Emergence and Within-Host Genetic Evolution of Methicillin-Resistant Staphylococcus aureus Resistant to Linezolid in a Cystic Fibrosis Patient.

Authors:  Caroline Rouard; Fabien Garnier; Jeremy Leraut; Margaux Lepainteur; Lalaina Rahajamananav; Jeanne Languepin; Marie-Cécile Ploy; Nadège Bourgeois-Nicolaos; Florence Doucet-Populaire
Journal:  Antimicrob Agents Chemother       Date:  2018-11-26       Impact factor: 5.191

8.  Tedizolid susceptibility in linezolid- and vancomycin-resistant Enterococcus faecium isolates.

Authors:  E-M Klupp; A Both; C Belmar Campos; H Büttner; C König; M Christopeit; M Christner; M Aepfelbacher; H Rohde
Journal:  Eur J Clin Microbiol Infect Dis       Date:  2016-08-15       Impact factor: 3.267

Review 9.  [Resistance to "last resort" antibiotics in Gram-positive cocci: The post-vancomycin era].

Authors:  Sandra Rincón; Diana Panesso; Lorena Díaz; Lina P Carvajal; Jinnethe Reyes; José M Munita; César A Arias
Journal:  Biomedica       Date:  2014-04       Impact factor: 0.935

10.  Genome sequencing of linezolid-resistant Streptococcus pneumoniae mutants reveals novel mechanisms of resistance.

Authors:  Jie Feng; Andréanne Lupien; Hélène Gingras; Jessica Wasserscheid; Ken Dewar; Danielle Légaré; Marc Ouellette
Journal:  Genome Res       Date:  2009-04-06       Impact factor: 9.043
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.