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Literature DB >> 1815527

Synthesis and anti-inflammatory and analgesic activity of some 3-(1-adamantyl)-4-substituted-5-mercapto-1,2,4-triazoles.

Abstract

The synthesis of a series of 4,5-disubstituted-3-(1-adamantyl)- 1,2,4-triazoles is described. The compounds 3-(1-adamantyl)4-methyl, ethyl and benzyl-5-mercapto-1,2,4-triazoles (3a, 3b and 3f) produced a high dose-dependent anti-inflammatory activity against carrageenin-induced paw oedema in rats. The analgesic activity of these active compounds correlated with their anti-inflammatory activities.

Entities: Chemical Disease Species

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Year: 1991 PMID： 1815527

Source DB: PubMed Journal: Arzneimittelforschung ISSN： 0004-4172

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Cited

23 in total

1. The in vivo metabolism of 5-(4-nitrophenyl)-4-(2-phenylethyl)-2,4-dihydro-3H-1,2,4-triazole-3-thione in rats.

Authors: E E Oruç; L Kabasakal; S Rollas
Journal: Eur J Drug Metab Pharmacokinet Date: 2003 Apr-Jun Impact factor: 2.441

2. 3-(Adamantan-1-yl)-4-ethyl-1H-1,2,4-triazole-5(4H)-thione.

Authors: Ali A El-Emam; Nasser R El-Brollosy; Hazem A Ghabbour; Ching Kheng Quah; Hoong-Kun Fun
Journal: Acta Crystallogr Sect E Struct Rep Online Date: 2012-04-13

3. 3-(Adamantan-1-yl)-4-phenyl-1-[(4-phenyl-piperazin-1-yl)meth-yl]-1H-1,2,4-triazole-5(4H)-thione.

Authors: Ebtehal S Al-Abdullah; Hanadi H Asiri; Ali El-Emam; Seik Weng Ng
Journal: Acta Crystallogr Sect E Struct Rep Online Date: 2012-01-11

4. 3-(Adamantan-1-yl)-1-[(4-benzyl-piperazin-1-yl)meth-yl]-4-phenyl-1H-1,2,4-triazole-5(4H)-thione.

Authors: Ebtehal S Al-Abdullah; Hanadi H Asiri; Ali El-Emam; Seik Weng Ng
Journal: Acta Crystallogr Sect E Struct Rep Online Date: 2012-01-11

5. Ethyl 4-{[3-(adamantan-1-yl)-4-phenyl-5-sulfanyl-idene-4,5-dihydro-1H-1,2,4-triazol-1-yl]meth-yl}piperazine-1-carboxyl-ate.

Authors: Ebtehal S Al-Abdullah; Hanadi H Asiri; Ali A El-Emam; Seik Weng Ng
Journal: Acta Crystallogr Sect E Struct Rep Online Date: 2012-01-31

Synthesis and anti-inflammatory and analgesic activity of some 3-(1-adamantyl)-4-substituted-5-mercapto-1,2,4-triazoles.

1. The in vivo metabolism of 5-(4-nitrophenyl)-4-(2-phenylethyl)-2,4-dihydro-3H-1,2,4-triazole-3-thione in rats.

2. 3-(Adamantan-1-yl)-4-ethyl-1H-1,2,4-triazole-5(4H)-thione.

3. 3-(Adamantan-1-yl)-4-phenyl-1-[(4-phenyl-piperazin-1-yl)meth-yl]-1H-1,2,4-triazole-5(4H)-thione.

4. 3-(Adamantan-1-yl)-1-[(4-benzyl-piperazin-1-yl)meth-yl]-4-phenyl-1H-1,2,4-triazole-5(4H)-thione.

5. Ethyl 4-{[3-(adamantan-1-yl)-4-phenyl-5-sulfanyl-idene-4,5-dihydro-1H-1,2,4-triazol-1-yl]meth-yl}piperazine-1-carboxyl-ate.

6. 5-(Adamantan-1-yl)-3-anilinomethyl-2,3-di-hydro-1,3,4-oxa-diazole-2-thione.

7. 4-Benzyl-3-(thio-phen-2-yl)-4,5-di-hydro-1H-1,2,4-triazole-5-thione.

8. 5-(Adamantan-1-yl)-3-(benzyl-sulfan-yl)-4-methyl-4H-1,2,4-triazole.

9. 3-(Adamantan-1-yl)-4-ethyl-1-[(4-phenyl-piperazin-1-yl)meth-yl]-1H-1,2,4-triazole-5(4H)-thione.

10. 5-(Adamantan-1-yl)-3-[(4-benzyl-piperazin-1-yl)meth-yl]-1,3,4-oxadiazole-2(3H)-thione.