Literature DB >> 18068364

Synthesis and antimycobacterial evaluation of new trans-cinnamic acid hydrazide derivatives.

Samir A Carvalho1, Edson F da Silva, Marcus V N de Souza, Maria C S Lourenço, Felipe R Vicente.   

Abstract

In this work, we report the synthesis and the antimycobacterial evaluation of new trans-cinnamic acid derivatives of isonicotinic acid series (5) and benzoic acid series (6), designed by exploring the molecular hybridization approach between isoniazid (1) and trans-cinnamic acid derivative (3). The minimum inhibitory concentration (MIC) of the compounds 5a-d and 6c exhibited activity between 3.12 and 12.5 microg/mL and could be a good start point to find new lead compounds against multi-drug resistant tuberculosis.

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Year:  2007        PMID： 18068364     DOI： 10.1016/j.bmcl.2007.11.091

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  21 in total

1.  Dehydrozingerone Inspired Styryl Hydrazine Thiazole Hybrids as Promising Class of Antimycobacterial Agents.

Authors:  Girish A Hampannavar; Rajshekhar Karpoormath; Mahesh B Palkar; Mahamadhanif S Shaikh; Balakumar Chandrasekaran
Journal:  ACS Med Chem Lett       Date:  2016-05-13       Impact factor: 4.345

2.  Design and synthesis of novel 2-(6-thioxo-1,3,5-thiadiazinan-3-yl)-N'-phenylacethydrazide derivatives as potential fungicides.

Authors:  Xiaobin Wang; Xincan Fu; Jinghua Yan; An Wang; Mengqi Wang; Min Chen; Chunlong Yang; Yimin Song
Journal:  Mol Divers       Date:  2018-11-21       Impact factor: 2.943

3.  N'-(4-Bromo-phenyl-sulfon-yl)isonicotino-hydrazide.

Authors:  Islam Ullah Khan; Muhammad Ashfaq; Muhammad Nadeem Arshad; Hamad Ahmad; Ghulam Mustafa
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2009-07-25

4.  N'-[(2E)-3-Phenyl-prop-2-eno-yl]benzo-hydrazide.

Authors:  Samir A Carvalho; Edson F da Silva; Edward R T Tiekink; James L Wardell; Solange M S V Wardell
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2009-11-18

5.  Gold Nanoparticle-Conjugated Cinnamic Acid Exhibits Antiacanthamoebic and Antibacterial Properties.

Authors:  Ayaz Anwar; Ruqaiyyah Siddiqui; Muhammad Raza Shah; Naveed Ahmed Khan
Journal:  Antimicrob Agents Chemother       Date:  2018-08-27       Impact factor: 5.191

6.  (2E)-N'-Benzoyl-3-(4-nitro-phen-yl)prop-2-enohydrazide.

Authors:  Samir A Carvalho; Edson F da Silva; Marcus V N de Souza; Edward R T Tiekink; James L Wardell; Solange M S V Wardell
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2009-12-16

7.  (2E)-N'-[(E)-4-Chloro-benzyl-idene]-3-phenyl-prop-2-enohydrazide monohydrate.

Authors:  Samir A Carvalho; Edson F da Silva; Carlos A M Fraga; Solange M S V Wardell; James L Wardell; Edward R T Tiekink
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2010-08-28

8.  (E)-4-{2-[(2-Hy-droxy-naphthalen-1-yl)methyl-idene]hydrazinecarbon-yl}pyridinium nitrate.

Authors:  Rahman Bikas; Hassan Hosseini Monfared; Tadeusz Lis; Milosz Siczek
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2012-01-11

9.  Benzylsulfanyl benzo-heterocycle amides and hydrazones as new agents against drug-susceptible and resistant Mycobacterium tuberculosis.

Authors:  Xiaoyun Lu; Xianglong Hu; Zhiyong Liu; Tianyu Zhang; Ruibing Wang; Baojie Wan; Scott G Franzblau; Qidong You
Journal:  Medchemcomm       Date:  2017-04-28       Impact factor: 3.597

10.  (E)-2-(2-Hy-droxy-5-iodo-benzyl-idene)hydrazinecarboxamide.

Authors:  Rahman Bikas; Samra Nikbakht Sardari; Seyed Sajjad Hosseini; Gholam Hossein Shahverdizadeh; Behrouz Notash
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2012-03-17
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