| Literature DB >> 29967024 |
Ayaz Anwar1, Ruqaiyyah Siddiqui1, Muhammad Raza Shah2, Naveed Ahmed Khan3.
Abstract
trans-Cinnamic acid (CA) is a natural organic compound. Using amoebicidal assays, for the first time we showed that CA affected the viability of the protist pathogen Acanthamoeba castellanii Conjugation with gold nanoparticles (AuNPs) enhanced the antiamoebic effects of CA. CA-coated AuNPs (CA-AuNPs) also exhibited significant excystation and encystation activity, compared to CA and AuNPs alone. Pretreatment of amoebae with CA-AuNPs inhibited A. castellanii-mediated host cell cytotoxicity. Moreover, CA-AuNPs exhibited potent effects against methicillin-resistant Staphylococcus aureus and neuropathogenic Escherichia coli K1 and protected host cells against bacteria-mediated host cell death.Entities:
Keywords: Acanthamoeba; E. coli; MRSA; cinnamic acid; gold nanoparticles
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Year: 2018 PMID: 29967024 PMCID: PMC6125513 DOI: 10.1128/AAC.00630-18
Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN: 0066-4804 Impact factor: 5.191