Literature DB >> 29967024

Gold Nanoparticle-Conjugated Cinnamic Acid Exhibits Antiacanthamoebic and Antibacterial Properties.

Ayaz Anwar1, Ruqaiyyah Siddiqui1, Muhammad Raza Shah2, Naveed Ahmed Khan3.   

Abstract

trans-Cinnamic acid (CA) is a natural organic compound. Using amoebicidal assays, for the first time we showed that CA affected the viability of the protist pathogen Acanthamoeba castellanii Conjugation with gold nanoparticles (AuNPs) enhanced the antiamoebic effects of CA. CA-coated AuNPs (CA-AuNPs) also exhibited significant excystation and encystation activity, compared to CA and AuNPs alone. Pretreatment of amoebae with CA-AuNPs inhibited A. castellanii-mediated host cell cytotoxicity. Moreover, CA-AuNPs exhibited potent effects against methicillin-resistant Staphylococcus aureus and neuropathogenic Escherichia coli K1 and protected host cells against bacteria-mediated host cell death.
Copyright © 2018 American Society for Microbiology.

Entities:  

Keywords:  Acanthamoeba; E. coli; MRSA; cinnamic acid; gold nanoparticles

Mesh:

Substances:

Year:  2018        PMID: 29967024      PMCID: PMC6125513          DOI: 10.1128/AAC.00630-18

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN: 0066-4804            Impact factor:   5.191


  21 in total

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