Literature DB >> 18020344

Multicomponent approach to the synthesis of oxidized amides through nitrile hydrozirconation.

Shuangyi Wan1, Michael E Green, Jung-Hyun Park, Paul E Floreancig.   

Abstract

"Oxidized" amides, as represented by acyl aminals and acyl hemiaminals, are integral subunits of several natural products that exhibit useful biological activity. In this paper a multicomponent approach to these groups from acylimine intermediates is demonstrated. The acylimines are accessed through a sequence of nitrile hydrozirconation and acylation, making this highly versatile amide synthesis useful for a range of applications in target- and diversity-oriented synthesis.

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Year:  2007        PMID： 18020344      PMCID： PMC2562210          DOI： 10.1021/ol702184n

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  23 in total

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