| Literature DB >> 14971894 |
George R Pettit1, Jun-Ping Xu, Jean-Charles Chapuis, Robin K Pettit, Larry P Tackett, Dennis L Doubek, John N A Hooper, Jean M Schmidt.
Abstract
The Indo-Pacific marine sponge Ircinia ramosa has been found to contain two powerful (GI50 from 0.001 to <0.0001 microg/mL) murine and human cancer cell growth inhibitors. Both were isolated (10(-3)-10(-4)% yields) by cancer cell line bioassay-guided techniques and named irciniastatins A (1) and B (2). Structural elucidation by a combination of spectral analyses, primarily high resolution mass and 2D-NMR (principally APT, HMQC, HMBC, and ROESY) spectroscopy, revealed the unusual structures 1 and 2.Entities:
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Year: 2004 PMID： 14971894 DOI： 10.1021/jm030207d
Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 7.446