| Literature DB >> 17319675 |
Ning Shangguan1, Sezgin Kiren, Lawrence J Williams.
Abstract
A formal synthesis of psymberin (irciniastatin A) is presented. Notable features of the synthesis include the chemo-, regio-, and stereoselective oxidation of a 1,3-disubstituted allene, a configuration-dependent spirodiepoxide opening, the efficient syntheses of functionalized trans-2,6-disubstituted pyrans, and the union of a highly functionalized aldehyde with a pentasubstituted aryl homoenolate to give a dihydroisocumarin. [structure: see text]Entities:
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Year: 2007 PMID： 17319675 DOI： 10.1021/ol063143k
Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005