Literature DB >> 19152262

Multicomponent synthesis of alpha-branched amides.

Mikkel V DeBenedetto1, Michael E Green, Shuangyi Wan, Jung-Hyun Park, Paul E Floreancig.   

Abstract

Alpha-branched amides are prepared by multicomponent reactions in which nitriles undergo hydrozirconation to form metalloimines that react with acyl chlorides. The resulting acylimines react with a variety of pi-nucleophiles in the presence of Lewis acids to form the desired amides.

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Year:  2009        PMID： 19152262      PMCID： PMC2665885          DOI： 10.1021/ol802764j

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  26 in total

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