Literature DB >> 17971750

A simple synthesis of 2-thiohydantoins.

Zerong Daniel Wang1, Samia O Sheikh, Yulu Zhang.   

Abstract

2-Thiohydantoin derivatives are produced by heating a mixture of thiourea and an alpha-amino acid. The method described offers the advantages of simplicity, low cost, easy work-up and scalability.

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Year:  2006        PMID： 17971750      PMCID： PMC6148508          DOI： 10.3390/11100739

Source DB:  PubMed          Journal:  Molecules        ISSN： 1420-3049            Impact factor:   4.411


  24 in total

1.  Solid phase synthesis of hydantoins by thermal cyclization and screening of reaction conditions using APOS 1200.

Authors:  W Karnbrock; M Deeg; J Gerhardt; W Rapp
Journal:  Mol Divers       Date:  1998       Impact factor: 2.943

2.  IP-COSY, a totally in-phase and sensitive COSY experiment.

Authors:  Youlin Xia; Glen Legge; Kyu-Yeon Jun; Yulan Qi; Hunjoong Lee; Xiaolian Gao
Journal:  Magn Reson Chem       Date:  2005-05       Impact factor: 2.447

3.  [Antithyroid action and molecular structure. I. A study of thiohydantoins and their methyl esters].

Authors:  J CHEYMOL; P CHABRIER; Y GAY
Journal:  Arch Int Pharmacodyn Ther       Date:  1951-08-01

4.  Determination of the carboxyl termini of proteins with ammonium thiocyanate and acetic anhydride, with direct identification of the thiohydantoins.

Authors:  L D Cromwell; G R Stark
Journal:  Biochemistry       Date:  1969-12       Impact factor: 3.162

5.  Sequential degradation of peptides from their carboxyl termini with ammonium thiocyanate and acetic anhydride.

Authors:  G R Stark
Journal:  Biochemistry       Date:  1968-05       Impact factor: 3.162

6.  5-substituted-2-thiohydantoin analogs as a novel class of antitumor agents.

Authors:  A M al-Obaid; H I el-Subbagh; A I Khodair; M M Elmazar
Journal:  Anticancer Drugs       Date:  1996-11       Impact factor: 2.248

7.  Solution-Phase Synthesis of a Combinatorial Thiohydantoin Library(1).

Authors:  Mui Mui Sim; Arasu Ganesan
Journal:  J Org Chem       Date:  1997-05-16       Impact factor: 4.354

8.  Fluorous synthesis of hydantoins and thiohydantoins.

Authors:  Wei Zhang; Yimin Lu
Journal:  Org Lett       Date:  2003-07-10       Impact factor: 6.005

9.  Carboxy-terminal sequencing: formation and hydrolysis of C-terminal peptidylthiohydantoins.

Authors:  J M Bailey; J E Shively
Journal:  Biochemistry       Date:  1990-03-27       Impact factor: 3.162

10.  S-glucosylated hydantoins as new antiviral agents.

Authors:  A A el-Barbary; A I Khodair; E B Pedersen; C Nielsen
Journal:  J Med Chem       Date:  1994-01-07       Impact factor: 7.446
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  10 in total

1.  Synthesis, spectroscopy, and theoretical calculations of some 2-thiohydantoin derivatives as possible new fungicides.

Authors:  Katarzyna Kobyłka; Grzegorz Żuchowski; Waldemar Tejchman; Krzysztof K Zborowski
Journal:  J Mol Model       Date:  2019-08-24       Impact factor: 1.810

2.  5-Isopropyl-5-methyl-2-sulfanylidene-imidazolidin-4-one.

Authors:  Masaki Ichitani; Soh-Ichi Kitoh; Shuhei Fujinami; Mitsuhiro Suda; Mitsunori Honda; Ko-Ki Kunimoto
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2013-05-25

3.  Determination of Acid Dissociation Constants (pK a ) of Bicyclic Thiohydantoin-Pyrrolidine Compounds in 20% Ethanol-Water Hydroorganic Solvent.

Authors:  Yahya Nural; H Ali Döndaş; Hayati Sarı; Hasan Atabey; Samet Belveren; Müge Gemili
Journal:  Int J Anal Chem       Date:  2014-03-30       Impact factor: 1.885

4.  Synthesis and herbicidal activity of 5-(4-hydroxybenzyl)-2-thioxoimidazolidin-4-one esters.

Authors:  Jintao Han; Jinmin Wang; Hongbo Dong; Jianping Lei; Mingan Wang; Jianxin Fang
Journal:  Molecules       Date:  2011-03-30       Impact factor: 4.411

5.  Synthesis of new imidazolidin-2,4-dione and 2-thioxoimidazolidin-4-ones via C-phenylglycine derivatives.

Authors:  José Alixandre de Sousa Luis; José Maria Barbosa Filho; Bruno Freitas Lira; Isac Almeida Medeiros; Liana Clébia Soares Lima de Morais; Raline Mendonça dos Anjos; Alexsandro Fernandes Dos Santos; Cledualdo Soares de Oliveira; Petrônio Filgueiras de Athayde-Filho
Journal:  Molecules       Date:  2009-12-30       Impact factor: 4.411

6.  Protic Ionic Liquid as Reagent, Catalyst, and Solvent: 1-Methylimidazolium Thiocyanate.

Authors:  Ivan A Andreev; Nina K Ratmanova; André U Augustin; Olga A Ivanova; Irina I Levina; Victor N Khrustalev; Daniel B Werz; Igor V Trushkov
Journal:  Angew Chem Int Ed Engl       Date:  2021-02-26       Impact factor: 15.336

7.  Development of Novel 1,3-Disubstituted-2-Thiohydantoin Analogues with Potent Anti-Inflammatory Activity; In Vitro and In Silico Assessments.

Authors:  Salma M Khirallah; Heba M M Ramadan; Ahmed Shawky; Safa H Qahl; Roua S Baty; Nada Alqadri; Amnah Mohammed Alsuhaibani; Mariusz Jaremko; Abdul-Hamid Emwas; Essa M Saied
Journal:  Molecules       Date:  2022-09-23       Impact factor: 4.927

8.  rac-5-(1-Methyl-eth-yl)-2-sulfanylidene-imidazolidin-4-one.

Authors:  Rosane de P Castro; Fernando C Macedo; Tiago O Brito; Angelo de Fátima; José R Sabino
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2013-04-05

9.  Facile synthesis of 5-arylidene thiohydantoin by sequential sulfonylation/desulfination reaction.

Authors:  Jintao Han; Hongbo Dong; Zhihong Xu; Jianping Lei; Mingan Wang
Journal:  Int J Mol Sci       Date:  2013-06-13       Impact factor: 5.923

Review 10.  1H-Imidazol-4(5H)-ones and thiazol-4(5H)-ones as emerging pronucleophiles in asymmetric catalysis.

Authors:  Antonia Mielgo; Claudio Palomo
Journal:  Beilstein J Org Chem       Date:  2016-05-09       Impact factor: 2.883
  10 in total

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