Literature DB >> 10729901

Solid phase synthesis of hydantoins by thermal cyclization and screening of reaction conditions using APOS 1200.

W Karnbrock1, M Deeg, J Gerhardt, W Rapp.   

Abstract

A novel strategy for solid-phase synthesis of hydantoins with high optical purity is described using a thermal pH-neutral cyclization and simultaneous release from resin. Hereby even hydantoins bearing a pH-sensitive side chain (protection) are available. The reaction conditions are well screened applying the parallel organic synthesizer APOS 1200.

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Year:  1998        PMID： 10729901     DOI： 10.1023/a:1009659303984

Source DB:  PubMed          Journal:  Mol Divers        ISSN： 1381-1991            Impact factor:   2.943


  2 in total

1.  Solid and Solution Phase Organic Syntheses of Oligomeric Thioureas.

Authors:  Joseph Smith; Jennifer L. Liras; Stephen E. Schneider; Eric V. Anslyn
Journal:  J Org Chem       Date:  1996-12-13       Impact factor: 4.354

2.  "Diversomers": an approach to nonpeptide, nonoligomeric chemical diversity.

Authors:  S H DeWitt; J S Kiely; C J Stankovic; M C Schroeder; D M Cody; M R Pavia
Journal:  Proc Natl Acad Sci U S A       Date:  1993-08-01       Impact factor: 11.205
  2 in total
  2 in total

1.  Solid-phase synthesis of a library of amphipatic hydantoins. Discovery of new hits for TRPV1 blockade.

Authors:  Guillermo Gerona-Navarro; Rosario González-Muñiz; Asia Fernández-Carvajal; José M González-Ros; Antonio Ferrer-Montiel; Cristina Carreño; Fernando Albericio; Miriam Royo
Journal:  ACS Comb Sci       Date:  2011-07-08       Impact factor: 3.784

2.  A simple synthesis of 2-thiohydantoins.

Authors:  Zerong Daniel Wang; Samia O Sheikh; Yulu Zhang
Journal:  Molecules       Date:  2006-10-02       Impact factor: 4.411
  2 in total

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