Literature DB >> 17854190

Do ligand binding and solvent exclusion alter the electrostatic character within the oxyanion hole of an enzymatic active site?

Paul A Sigala1, Aaron T Fafarman, Patrick E Bogard, Steven G Boxer, Daniel Herschlag.   

Abstract

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Year:  2007        PMID： 17854190      PMCID： PMC3171184          DOI： 10.1021/ja075605a

Source DB:  PubMed          Journal:  J Am Chem Soc        ISSN： 0002-7863            Impact factor:   15.419


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  15 in total

1.  Enzymes work by solvation substitution rather than by desolvation.

Authors:  A Warshel; J Aqvist; S Creighton
Journal:  Proc Natl Acad Sci U S A       Date:  1989-08       Impact factor: 11.205

2.  Stabilization of charges on isolated ionic groups sequestered in proteins by polarized peptide units.

Authors:  F A Quiocho; J S Sack; N K Vyas
Journal:  Nature       Date:  1987 Oct 8-14       Impact factor: 49.962

3.  Alternative view of enzyme reactions.

Authors:  M J Dewar; D M Storch
Journal:  Proc Natl Acad Sci U S A       Date:  1985-04       Impact factor: 11.205

4.  Electrostatic screening of charge and dipole interactions with the helix backbone.

Authors:  D J Lockhart; P S Kim
Journal:  Science       Date:  1993-04-09       Impact factor: 47.728

5.  Site-specific conversion of cysteine thiols into thiocyanate creates an IR probe for electric fields in proteins.

Authors:  Aaron T Fafarman; Lauren J Webb; Jessica I Chuang; Steven G Boxer
Journal:  J Am Chem Soc       Date:  2006-10-18       Impact factor: 15.419

6.  Ultraviolet spectroscopic evidence for decreased motion of the active site tyrosine residue of delta 5-3-ketosteroid isomerase by steroid binding.

Authors:  Q Zhao; Y K Li; A S Mildvan; P Talalay
Journal:  Biochemistry       Date:  1995-05-16       Impact factor: 3.162

7.  Vibrational Stark effects calibrate the sensitivity of vibrational probes for electric fields in proteins.

Authors:  Ian T Suydam; Steven G Boxer
Journal:  Biochemistry       Date:  2003-10-21       Impact factor: 3.162

8.  Using nitrile-derivatized amino acids as infrared probes of local environment.

Authors:  Zelleka Getahun; Cheng-Yen Huang; Ting Wang; Brenda De León; William F DeGrado; Feng Gai
Journal:  J Am Chem Soc       Date:  2003-01-15       Impact factor: 15.419

9.  A low-barrier hydrogen bond in the catalytic triad of serine proteases.

Authors:  P A Frey; S A Whitt; J B Tobin
Journal:  Science       Date:  1994-06-24       Impact factor: 47.728

10.  13C NMR relaxation studies of backbone and side chain motion of the catalytic tyrosine residue in free and steroid-bound delta 5-3-ketosteroid isomerase.

Authors:  Q Zhao; C Abeygunawardana; A S Mildvan
Journal:  Biochemistry       Date:  1996-02-06       Impact factor: 3.162
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  31 in total

1.  Impact of mutation on proton transfer reactions in ketosteroid isomerase: insights from molecular dynamics simulations.

Authors:  Dhruva K Chakravorty; Sharon Hammes-Schiffer
Journal:  J Am Chem Soc       Date:  2010-06-02       Impact factor: 15.419

Review 2.  Vibrational Spectroscopic Map, Vibrational Spectroscopy, and Intermolecular Interaction.

Authors:  Carlos R Baiz; Bartosz Błasiak; Jens Bredenbeck; Minhaeng Cho; Jun-Ho Choi; Steven A Corcelli; Arend G Dijkstra; Chi-Jui Feng; Sean Garrett-Roe; Nien-Hui Ge; Magnus W D Hanson-Heine; Jonathan D Hirst; Thomas L C Jansen; Kijeong Kwac; Kevin J Kubarych; Casey H Londergan; Hiroaki Maekawa; Mike Reppert; Shinji Saito; Santanu Roy; James L Skinner; Gerhard Stock; John E Straub; Megan C Thielges; Keisuke Tominaga; Andrei Tokmakoff; Hajime Torii; Lu Wang; Lauren J Webb; Martin T Zanni
Journal:  Chem Rev       Date:  2020-06-29       Impact factor: 60.622

3.  Quantitative, directional measurement of electric field heterogeneity in the active site of ketosteroid isomerase.

Authors:  Aaron T Fafarman; Paul A Sigala; Jason P Schwans; Timothy D Fenn; Daniel Herschlag; Steven G Boxer
Journal:  Proc Natl Acad Sci U S A       Date:  2012-01-17       Impact factor: 11.205

4.  Site-Specific Spectroscopic Reporters of the Local Electric Field, Hydration, Structure, and Dynamics of Biomolecules.

Authors:  Matthias M Waegele; Robert M Culik; Feng Gai
Journal:  J Phys Chem Lett       Date:  2011-09-23       Impact factor: 6.475

5.  Solvatochromism and the solvation structure of benzophenone.

Authors:  Justin E Elenewski; John C Hackett
Journal:  J Chem Phys       Date:  2013-06-14       Impact factor: 3.488

6.  Determining the catalytic role of remote substrate binding interactions in ketosteroid isomerase.

Authors:  Jason P Schwans; Daniel A Kraut; Daniel Herschlag
Journal:  Proc Natl Acad Sci U S A       Date:  2009-08-12       Impact factor: 11.205

7.  Testing geometrical discrimination within an enzyme active site: constrained hydrogen bonding in the ketosteroid isomerase oxyanion hole.

Authors:  Paul A Sigala; Daniel A Kraut; Jose M M Caaveiro; Brandon Pybus; Eliza A Ruben; Dagmar Ringe; Gregory A Petsko; Daniel Herschlag
Journal:  J Am Chem Soc       Date:  2008-09-23       Impact factor: 15.419

8.  Ketosteroid isomerase provides further support for the idea that enzymes work by electrostatic preorganization.

Authors:  Shina C L Kamerlin; Pankaz K Sharma; Zhen T Chu; Arieh Warshel
Journal:  Proc Natl Acad Sci U S A       Date:  2010-02-11       Impact factor: 11.205

Review 9.  Catalytic efficiency of enzymes: a theoretical analysis.

Authors:  Sharon Hammes-Schiffer
Journal:  Biochemistry       Date:  2012-12-20       Impact factor: 3.162

Review 10.  Fundamental challenges in mechanistic enzymology: progress toward understanding the rate enhancements of enzymes.

Authors:  Daniel Herschlag; Aditya Natarajan
Journal:  Biochemistry       Date:  2013-03-14       Impact factor: 3.162
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