Literature DB >> 17804232

Evaluation of protein farnesyltransferase substrate specificity using synthetic peptide libraries.

Amanda J Krzysiak1, Sarah A Scott, Katherine A Hicks, Carol A Fierke, Richard A Gibbs.   

Abstract

Farnesylation, catalyzed by protein farnesyltransferase (FTase), is an important post-translational modification guiding cellular localization. Recently predictive models for identifying FTase substrates have been reported. Here we evaluate these models through screening of dansylated-GCaaS peptides, which also provides new insights into the protein substrate selectivity of FTase.

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Year:  2007        PMID： 17804232      PMCID： PMC2077820          DOI： 10.1016/j.bmcl.2007.08.024

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  14 in total

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