Literature DB >> 14737124

Opinion: Searching for the elusive targets of farnesyltransferase inhibitors.

Saïd M Sebti1, Channing J Der.   

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Year:  2003        PMID： 14737124     DOI： 10.1038/nrc1234

Source DB:  PubMed          Journal:  Nat Rev Cancer        ISSN： 1474-175X            Impact factor:   60.716


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  54 in total

1.  A tagging-via-substrate technology for detection and proteomics of farnesylated proteins.

Authors:  Yoonjung Kho; Sung Chan Kim; Chen Jiang; Deb Barma; Sung Won Kwon; Jinke Cheng; Janis Jaunbergs; Carolyn Weinbaum; Fuyuhiko Tamanoi; John Falck; Yingming Zhao
Journal:  Proc Natl Acad Sci U S A       Date:  2004-08-12       Impact factor: 11.205

2.  Rational design of small molecule inhibitors targeting RhoA subfamily Rho GTPases.

Authors:  Xun Shang; Fillipo Marchioni; Nisha Sipes; Chris R Evelyn; Moran Jerabek-Willemsen; Stefan Duhr; William Seibel; Matthew Wortman; Yi Zheng
Journal:  Chem Biol       Date:  2012-06-22

3.  Farnesyltransferase inhibitor tipifarnib inhibits Rheb prenylation and stabilizes Bax in acute myelogenous leukemia cells.

Authors:  Husheng Ding; Jennifer S McDonald; Seongseok Yun; Paula A Schneider; Kevin L Peterson; Karen S Flatten; David A Loegering; Ann L Oberg; Shaun M Riska; Shengbing Huang; Frank A Sinicrope; Alex A Adjei; Judith E Karp; X Wei Meng; Scott H Kaufmann
Journal:  Haematologica       Date:  2013-08-30       Impact factor: 9.941

Review 4.  Inhibition of Ras for cancer treatment: the search continues.

Authors:  Antonio T Baines; Dapeng Xu; Channing J Der
Journal:  Future Med Chem       Date:  2011-10       Impact factor: 3.808

5.  Geranylgeranyltransferase I inhibitors target RalB to inhibit anchorage-dependent growth and induce apoptosis and RalA to inhibit anchorage-independent growth.

Authors:  Samuel C Falsetti; De-an Wang; Hairuo Peng; Dora Carrico; Adrienne D Cox; Channing J Der; Andrew D Hamilton; Saïd M Sebti
Journal:  Mol Cell Biol       Date:  2007-09-17       Impact factor: 4.272

6.  Evaluation of alkyne-modified isoprenoids as chemical reporters of protein prenylation.

Authors:  Amanda J DeGraw; Charuta Palsuledesai; Joshua D Ochocki; Jonathan K Dozier; Stepan Lenevich; Mohammad Rashidian; Mark D Distefano
Journal:  Chem Biol Drug Des       Date:  2010-10-11       Impact factor: 2.817

7.  Evaluation of protein farnesyltransferase substrate specificity using synthetic peptide libraries.

Authors:  Amanda J Krzysiak; Sarah A Scott; Katherine A Hicks; Carol A Fierke; Richard A Gibbs
Journal:  Bioorg Med Chem Lett       Date:  2007-08-16       Impact factor: 2.823

8.  Simvastatin interacts synergistically with tipifarnib to induce apoptosis in leukemia cells through the disruption of RAS membrane localization and ERK pathway inhibition.

Authors:  Tamer A Ahmed; John Hayslip; Markos Leggas
Journal:  Leuk Res       Date:  2014-09-16       Impact factor: 3.156

9.  Farnesylation of retinal transducin underlies its translocation during light adaptation.

Authors:  Hidetoshi Kassai; Atsu Aiba; Kazuki Nakao; Kenji Nakamura; Motoya Katsuki; Wei-Hong Xiong; King-Wai Yau; Hiroo Imai; Yoshinori Shichida; Yoshinori Satomi; Toshifumi Takao; Toshiyuki Okano; Yoshitaka Fukada
Journal:  Neuron       Date:  2005-08-18       Impact factor: 17.173

10.  Differential requirement of CAAX-mediated posttranslational processing for Rheb localization and signaling.

Authors:  A B Hanker; N Mitin; R S Wilder; E P Henske; F Tamanoi; A D Cox; C J Der
Journal:  Oncogene       Date:  2009-10-19       Impact factor: 9.867
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