Literature DB >> 22783549

Solid-phase synthesis of C-terminal peptide libraries for studying the specificity of enzymatic protein prenylation.

Yen-Chih Wang1, Mark D Distefano.   

Abstract

Prenylation is an essential post-translational modification in all eukaryotes. Here we describe the synthesis of a 340-member library of peptides containing free C-termini on cellulose membranes. The resulting library was then used to probe the specificity of protein farnesyltransferase from S. cerevisiae.

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Year:  2012        PMID： 22783549      PMCID： PMC3682486          DOI： 10.1039/c2cc31713c

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  14 in total

1.  Characterization of a putative phosphorylation switch: adaptation of SPOT synthesis to analyze PDZ domain regulation mechanisms.

Authors:  Prisca Boisguerin; Bernhard Ay; Gerald Radziwill; Rafael D Fritz; Karin Moelling; Rudolf Volkmer
Journal:  Chembiochem       Date:  2007-12-17       Impact factor: 3.164

2.  Peptide arrays on cellulose support: SPOT synthesis, a time and cost efficient method for synthesis of large numbers of peptides in a parallel and addressable fashion.

Authors:  Kai Hilpert; Dirk F H Winkler; Robert E W Hancock
Journal:  Nat Protoc       Date:  2007       Impact factor: 13.491

3.  Evaluation of protein farnesyltransferase substrate specificity using synthetic peptide libraries.

Authors:  Amanda J Krzysiak; Sarah A Scott; Katherine A Hicks; Carol A Fierke; Richard A Gibbs
Journal:  Bioorg Med Chem Lett       Date:  2007-08-16       Impact factor: 2.823

4.  Identification and specificity profiling of protein prenyltransferase inhibitors using new fluorescent phosphoisoprenoids.

Authors:  Beatrice Dursina; Reinhard Reents; Christine Delon; Yaowen Wu; Mahesh Kulharia; Michael Thutewohl; Alexei Veligodsky; Alexandr Kalinin; Vladimir Evstifeev; Doina Ciobanu; Stefan E Szedlacsek; Herbert Waldmann; Roger S Goody; Kirill Alexandrov
Journal:  J Am Chem Soc       Date:  2006-03-08       Impact factor: 15.419

5.  Modulation of Ras and a-factor function by carboxyl-terminal proteolysis.

Authors:  V L Boyartchuk; M N Ashby; J Rine
Journal:  Science       Date:  1997-03-21       Impact factor: 47.728

6.  Targeting protein prenylation for cancer therapy.

Authors:  Norbert Berndt; Andrew D Hamilton; Saïd M Sebti
Journal:  Nat Rev Cancer       Date:  2011-10-24       Impact factor: 60.716

7.  Enzyme accessibility and solid supports: which molecular weight enzymes can be used on solid supports? An investigation using confocal Raman microscopy.

Authors:  Jürgen Kress; Riccardo Zanaletti; Augustin Amour; Mark Ladlow; Jeremy G Frey; Mark Bradley
Journal:  Chemistry       Date:  2002-08-16       Impact factor: 5.236

8.  Crystal structure of farnesyl protein transferase complexed with a CaaX peptide and farnesyl diphosphate analogue.

Authors:  C L Strickland; W T Windsor; R Syto; L Wang; R Bond; Z Wu; J Schwartz; H V Le; L S Beese; P C Weber
Journal:  Biochemistry       Date:  1998-11-24       Impact factor: 3.162

9.  Posttranslational modification of the Ha-ras oncogene protein: evidence for a third class of protein carboxyl methyltransferases.

Authors:  S Clarke; J P Vogel; R J Deschenes; J Stock
Journal:  Proc Natl Acad Sci U S A       Date:  1988-07       Impact factor: 11.205

10.  Substrate characterization of the Saccharomyces cerevisiae protein farnesyltransferase and type-I protein geranylgeranyltransferase.

Authors:  B E Caplin; L A Hettich; M S Marshall
Journal:  Biochim Biophys Acta       Date:  1994-03-16
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  10 in total

1.  Prenyltransferase Inhibitors: Treating Human Ailments from Cancer to Parasitic Infections.

Authors:  Joshua D Ochocki; Mark D Distefano
Journal:  Medchemcomm       Date:  2013-03       Impact factor: 3.597

2.  Synthesis and screening of peptide libraries with free C-termini.

Authors:  Yen-Chih Wang; Mark D Distefano
Journal:  Curr Top Pept Protein Res       Date:  2014

3.  A combination of metabolic labeling and 2D-DIGE analysis in response to a farnesyltransferase inhibitor facilitates the discovery of new prenylated proteins.

Authors:  Charuta C Palsuledesai; Joshua D Ochocki; Todd W Markowski; Mark D Distefano
Journal:  Mol Biosyst       Date:  2014-05

Review 4.  Isoprenoids and protein prenylation: implications in the pathogenesis and therapeutic intervention of Alzheimer's disease.

Authors:  Angela Jeong; Kiall Francis Suazo; W Gibson Wood; Mark D Distefano; Ling Li
Journal:  Crit Rev Biochem Mol Biol       Date:  2018-06       Impact factor: 8.250

Review 5.  Protein prenylation: enzymes, therapeutics, and biotechnology applications.

Authors:  Charuta C Palsuledesai; Mark D Distefano
Journal:  ACS Chem Biol       Date:  2014-12-08       Impact factor: 5.100

Review 6.  Site-Specific PEGylation of Therapeutic Proteins.

Authors:  Jonathan K Dozier; Mark D Distefano
Journal:  Int J Mol Sci       Date:  2015-10-28       Impact factor: 5.923

7.  Rapid analysis of protein farnesyltransferase substrate specificity using peptide libraries and isoprenoid diphosphate analogues.

Authors:  Yen-Chih Wang; Jonathan K Dozier; Lorena S Beese; Mark D Distefano
Journal:  ACS Chem Biol       Date:  2014-06-05       Impact factor: 5.100

Review 8.  Screening and Optimizing Antimicrobial Peptides by Using SPOT-Synthesis.

Authors:  Paula M López-Pérez; Elizabeth Grimsey; Luc Bourne; Ralf Mikut; Kai Hilpert
Journal:  Front Chem       Date:  2017-04-12       Impact factor: 5.221

9.  MALDI-MS Analysis of Peptide Libraries Expands the Scope of Substrates for Farnesyltransferase.

Authors:  Garrett L Schey; Peter H Buttery; Emily R Hildebrandt; Sadie X Novak; Walter K Schmidt; James L Hougland; Mark D Distefano
Journal:  Int J Mol Sci       Date:  2021-11-07       Impact factor: 5.923

10.  Towards the systematic mapping and engineering of the protein prenylation machinery in Saccharomyces cerevisiae.

Authors:  Viktor Stein; Marta H Kubala; Jason Steen; Sean M Grimmond; Kirill Alexandrov
Journal:  PLoS One       Date:  2015-03-13       Impact factor: 3.240
  10 in total

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