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Literature DB >> 20005705

Synthesis and screening of a CaaL peptide library versus FTase reveals a surprising number of substrates.

Amanda J Krzysiak¹, Animesh V Aditya, James L Hougland, Carol A Fierke, Richard A Gibbs.

Abstract

Proteins bearing a CaaL sequence are typically geranylgeranylated to enable their proper localization and function. We found that many of the dansyl-GCaaL peptides representing mammalian CaaL proteins can be farnesylated by FTase. This result may have important implications for prenylated protein biology. Copyright 2009 Elsevier Ltd. All rights reserved.

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Year: 2009 PMID： 20005705 PMCID： PMC2922960 DOI： 10.1016/j.bmcl.2009.11.011

Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823

22 in total

1. RhoB prenylation is driven by the three carboxyl-terminal amino acids of the protein: evidenced in vivo by an anti-farnesyl cysteine antibody.

Authors: R Baron; E Fourcade; I Lajoie-Mazenc; C Allal; B Couderc; R Barbaras; G Favre; J C Faye; A Pradines
Journal: Proc Natl Acad Sci U S A Date: 2000-10-10 Impact factor: 11.205

2. Geranylgeranyltransferase I inhibitors target RalB to inhibit anchorage-dependent growth and induce apoptosis and RalA to inhibit anchorage-independent growth.

Authors: Samuel C Falsetti; De-an Wang; Hairuo Peng; Dora Carrico; Adrienne D Cox; Channing J Der; Andrew D Hamilton; Saïd M Sebti
Journal: Mol Cell Biol Date: 2007-09-17 Impact factor: 4.272

Review 3. Thematic review series: lipid posttranslational modifications. Structural biology of protein farnesyltransferase and geranylgeranyltransferase type I.

Authors: Kimberly T Lane; Lorena S Beese
Journal: J Lipid Res Date: 2006-02-13 Impact factor: 5.922

Review 4. Geranylgeranyltransferase I as a target for anti-cancer drugs.

Authors: Mark R Philips; Adrienne D Cox
Journal: J Clin Invest Date: 2007-05 Impact factor: 14.808

5. Analysis of the eukaryotic prenylome by isoprenoid affinity tagging.

Authors: Uyen T T Nguyen; Zhong Guo; Christine Delon; Yaowen Wu; Celine Deraeve; Benjamin Fränzel; Robin S Bon; Wulf Blankenfeldt; Roger S Goody; Herbert Waldmann; Dirk Wolters; Kirill Alexandrov
Journal: Nat Chem Biol Date: 2009-02-15 Impact factor: 15.040

6. Evaluation of protein farnesyltransferase substrate specificity using synthetic peptide libraries.

Authors: Amanda J Krzysiak; Sarah A Scott; Katherine A Hicks; Carol A Fierke; Richard A Gibbs
Journal: Bioorg Med Chem Lett Date: 2007-08-16 Impact factor: 2.823

7. Rho Family GTPase modification and dependence on CAAX motif-signaled posttranslational modification.

Authors: Patrick J Roberts; Natalia Mitin; Patricia J Keller; Emily J Chenette; James P Madigan; Rachel O Currin; Adrienne D Cox; Oswald Wilson; Paul Kirschmeier; Channing J Der
Journal: J Biol Chem Date: 2008-07-09 Impact factor: 5.157

8. Blockade of protein geranylgeranylation inhibits Cdk2-dependent p27Kip1 phosphorylation on Thr187 and accumulates p27Kip1 in the nucleus: implications for breast cancer therapy.

Authors: Aslamuzzaman Kazi; Adam Carie; Michelle A Blaskovich; Cynthia Bucher; Van Thai; Stacy Moulder; Hairuo Peng; Dora Carrico; Erin Pusateri; Warren J Pledger; Norbert Berndt; Andrew Hamilton; Saïd M Sebti
Journal: Mol Cell Biol Date: 2009-02-09 Impact factor: 4.272

9. Context-dependent substrate recognition by protein farnesyltransferase.

Authors: James L Hougland; Corissa L Lamphear; Sarah A Scott; Richard A Gibbs; Carol A Fierke
Journal: Biochemistry Date: 2009-03-03 Impact factor: 3.162

10. Towards complete sets of farnesylated and geranylgeranylated proteins.

Authors: Sebastian Maurer-Stroh; Manfred Koranda; Wolfgang Benetka; Georg Schneider; Fernanda L Sirota; Frank Eisenhaber
Journal: PLoS Comput Biol Date: 2007-02-23 Impact factor: 4.475

9 in total

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Authors: Elaina A Zverina; Corissa L Lamphear; Elia N Wright; Carol A Fierke
Journal: Curr Opin Chem Biol Date: 2012-11-08 Impact factor: 8.822

2. Expansion of protein farnesyltransferase specificity using "tunable" active site interactions: development of bioengineered prenylation pathways.

Authors: James L Hougland; Soumyashree A Gangopadhyay; Carol A Fierke
Journal: J Biol Chem Date: 2012-09-19 Impact factor: 5.157

3. Protein Lipidation: Occurrence, Mechanisms, Biological Functions, and Enabling Technologies.

Authors: Hong Jiang; Xiaoyu Zhang; Xiao Chen; Pornpun Aramsangtienchai; Zhen Tong; Hening Lin
Journal: Chem Rev Date: 2018-01-02 Impact factor: 60.622

4. Farnesyl diphosphate analogues with aryl moieties are efficient alternate substrates for protein farnesyltransferase.

Authors: Thangaiah Subramanian; June E Pais; Suxia Liu; Jerry M Troutman; Yuta Suzuki; Karunai Leela Subramanian; Carol A Fierke; Douglas A Andres; H Peter Spielmann
Journal: Biochemistry Date: 2012-10-02 Impact factor: 3.162

Review 5. Isoprenoids and protein prenylation: implications in the pathogenesis and therapeutic intervention of Alzheimer's disease.

Authors: Angela Jeong; Kiall Francis Suazo; W Gibson Wood; Mark D Distefano; Ling Li
Journal: Crit Rev Biochem Mol Biol Date: 2018-06 Impact factor: 8.250