Literature DB >> 17631059

The X family portrait: structural insights into biological functions of X family polymerases.

Andrea F Moon1, Miguel Garcia-Diaz, Vinod K Batra, William A Beard, Katarzyna Bebenek, Thomas A Kunkel, Samuel H Wilson, Lars C Pedersen.   

Abstract

The mammalian family X DNA polymerases (DNA polymerases beta, lambda, mu, and TdT) contribute to base excision repair and double-strand break repair by virtue of their ability to fill short gaps in DNA. Structural information now exists for all four of these enzymes, making this the first mammalian polymerase family whose structural portrait is complete. Here we consider how distinctive structural features of these enzymes contribute to their biological functions in vivo.

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Year:  2007        PMID： 17631059      PMCID： PMC2128704          DOI： 10.1016/j.dnarep.2007.05.009

Source DB:  PubMed          Journal:  DNA Repair (Amst)        ISSN： 1568-7856


  85 in total

Review 1.  Structure-function studies of DNA polymerase lambda.

Authors:  Miguel Garcia-Diaz; Katarzyna Bebenek; Guanghua Gao; Lars C Pedersen; Robert E London; Thomas A Kunkel
Journal:  DNA Repair (Amst)       Date:  2005-10-04

2.  Activities and mechanism of DNA polymerase beta.

Authors:  William A Beard; Rajendra Prasad; Samuel H Wilson
Journal:  Methods Enzymol       Date:  2006       Impact factor: 1.600

3.  Structural analysis of strand misalignment during DNA synthesis by a human DNA polymerase.

Authors:  Miguel Garcia-Diaz; Katarzyna Bebenek; Joseph M Krahn; Lars C Pedersen; Thomas A Kunkel
Journal:  Cell       Date:  2006-01-27       Impact factor: 41.582

Review 4.  Structure and mechanism of DNA polymerase Beta.

Authors:  William A Beard; Samuel H Wilson
Journal:  Chem Rev       Date:  2006-02       Impact factor: 60.622

Review 5.  Mechanism of a genetic glissando: structural biology of indel mutations.

Authors:  Miguel Garcia-Diaz; Thomas A Kunkel
Journal:  Trends Biochem Sci       Date:  2006-03-20       Impact factor: 13.807

6.  A gradient of template dependence defines distinct biological roles for family X polymerases in nonhomologous end joining.

Authors:  Stephanie A Nick McElhinny; Jody M Havener; Miguel Garcia-Diaz; Raquel Juárez; Katarzyna Bebenek; Barbara L Kee; Luis Blanco; Thomas A Kunkel; Dale A Ramsden
Journal:  Mol Cell       Date:  2005-08-05       Impact factor: 17.970

7.  Nucleotide-induced DNA polymerase active site motions accommodating a mutagenic DNA intermediate.

Authors:  Vinod K Batra; William A Beard; David D Shock; Lars C Pedersen; Samuel H Wilson
Journal:  Structure       Date:  2005-08       Impact factor: 5.006

Review 8.  Repair of double-strand DNA breaks by the human nonhomologous DNA end joining pathway: the iterative processing model.

Authors:  Yunmei Ma; Haihui Lu; Klaus Schwarz; Michael R Lieber
Journal:  Cell Cycle       Date:  2005-09-27       Impact factor: 4.534

9.  Structural insight into the DNA polymerase beta deoxyribose phosphate lyase mechanism.

Authors:  Rajendra Prasad; Vinod K Batra; Xiao-Ping Yang; Joseph M Krahn; Lars C Pedersen; William A Beard; Samuel H Wilson
Journal:  DNA Repair (Amst)       Date:  2005-09-19

10.  Magnesium-induced assembly of a complete DNA polymerase catalytic complex.

Authors:  Vinod K Batra; William A Beard; David D Shock; Joseph M Krahn; Lars C Pedersen; Samuel H Wilson
Journal:  Structure       Date:  2006-04       Impact factor: 5.006
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  103 in total

1.  A new proofreading mechanism for lesion bypass by DNA polymerase-λ.

Authors:  Emmanuele Crespan; Giovanni Maga; Ulrich Hübscher
Journal:  EMBO Rep       Date:  2011-12-23       Impact factor: 8.807

Review 2.  Targeting DNA polymerase ß for therapeutic intervention.

Authors:  Eva M Goellner; David Svilar; Karen H Almeida; Robert W Sobol
Journal:  Curr Mol Pharmacol       Date:  2012-01       Impact factor: 3.339

Review 3.  Polymerases in nonhomologous end joining: building a bridge over broken chromosomes.

Authors:  Dale A Ramsden
Journal:  Antioxid Redox Signal       Date:  2010-10-28       Impact factor: 8.401

4.  Creative template-dependent synthesis by human polymerase mu.

Authors:  Andrea F Moon; Rajendrakumar A Gosavi; Thomas A Kunkel; Lars C Pedersen; Katarzyna Bebenek
Journal:  Proc Natl Acad Sci U S A       Date:  2015-08-03       Impact factor: 11.205

5.  2',3'-Dideoxycytidine Protects Dopaminergic Neurons in a Mouse Model of Parkinson's Disease.

Authors:  Jianyi Niu; Jing Xiong; Dan Hu; Fei Zeng; Shuke Nie; Shanping Mao; Tao Wang; Zhentao Zhang; Zhaohui Zhang
Journal:  Neurochem Res       Date:  2017-06-19       Impact factor: 3.996

Review 6.  Determinants of substrate specificity in RNA-dependent nucleotidyl transferases.

Authors:  Georges Martin; Sylvie Doublié; Walter Keller
Journal:  Biochim Biophys Acta       Date:  2007-12-14

Review 7.  Chlamydomonas reinhardtii: a convenient model system for the study of DNA repair in photoautotrophic eukaryotes.

Authors:  Daniel Vlcek; Andrea Sevcovicová; Barbara Sviezená; Eliska Gálová; Eva Miadoková
Journal:  Curr Genet       Date:  2007-11-09       Impact factor: 3.886

8.  Structural basis for a novel mechanism of DNA bridging and alignment in eukaryotic DSB DNA repair.

Authors:  Jérôme Gouge; Sandrine Rosario; Félix Romain; Frédéric Poitevin; Pierre Béguin; Marc Delarue
Journal:  EMBO J       Date:  2015-03-11       Impact factor: 11.598

Review 9.  Nonhomologous DNA end joining (NHEJ) and chromosomal translocations in humans.

Authors:  Michael R Lieber; Jiafeng Gu; Haihui Lu; Noriko Shimazaki; Albert G Tsai
Journal:  Subcell Biochem       Date:  2010

10.  Estrogen Drives Cellular Transformation and Mutagenesis in Cells Expressing the Breast Cancer-Associated R438W DNA Polymerase Lambda Protein.

Authors:  Antonia A Nemec; Korie B Bush; Jamie B Towle-Weicksel; B Frazier Taylor; Vincent Schulz; Joanne B Weidhaas; David P Tuck; Joann B Sweasy
Journal:  Mol Cancer Res       Date:  2016-09-12       Impact factor: 5.852
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