Literature DB >> 1763028

Antibody redesign by chain shuffling from random combinatorial immunoglobulin libraries.

A S Kang1, T M Jones, D R Burton.   

Abstract

A number of experiments on the shuffling of heavy and light chains from antibodies of defined specificity for the transition-state analogue hapten nitrophenyl phosphonamidate are described. The experiments report on the promiscuity of heavy and light chains in binding antigen and the feasibility of antibody redesign by this shuffling process. The concepts of incestuous and extraclonal promiscuous association are described. Shuffling opens the possibility of generating panels of antibodies with related specificity but of distinct idiotypic composition that may have significance in the use of human monoclonal antibodies in therapy.

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Year:  1991        PMID： 1763028      PMCID： PMC53085          DOI： 10.1073/pnas.88.24.11120

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  10 in total

1.  Assembly of combinatorial antibody libraries on phage surfaces: the gene III site.

Authors:  C F Barbas; A S Kang; R A Lerner; S J Benkovic
Journal:  Proc Natl Acad Sci U S A       Date:  1991-09-15       Impact factor: 11.205

2.  Linkage of recognition and replication functions by assembling combinatorial antibody Fab libraries along phage surfaces.

Authors:  A S Kang; C F Barbas; K D Janda; S J Benkovic; R A Lerner
Journal:  Proc Natl Acad Sci U S A       Date:  1991-05-15       Impact factor: 11.205

3.  The role of the VL- and VH-segments in the preferential reassociation of immunoglobulin subunits.

Authors:  P A Hamel; M H Klein; K J Dorrington
Journal:  Mol Immunol       Date:  1986-05       Impact factor: 4.407

4.  Relative noncovalent association constant between immunoglobulin H and L chains is unrelated to their expression or antigen-binding activity.

Authors:  P A Hamel; M H Klein; S J Smith-Gill; K J Dorrington
Journal:  J Immunol       Date:  1987-11-01       Impact factor: 5.422

5.  Metalloantibodies.

Authors:  B L Iverson; S A Iverson; V A Roberts; E D Getzoff; J A Tainer; S J Benkovic; R A Lerner
Journal:  Science       Date:  1990-08-10       Impact factor: 47.728

6.  Binding studies on heavy-light chain recombinant hybrid immunoglobulins A derived from murine myeloma anti-fructofuranans.

Authors:  D G Streefkerk; M Vrana; C P Glaudemans
Journal:  J Immunol       Date:  1978-02       Impact factor: 5.422

7.  Subunit interactions in mouse myeloma proteins with anti-galactan activity.

Authors:  B N Manjula; C P Glaudemans; E B Mushinski; M Potter
Journal:  Proc Natl Acad Sci U S A       Date:  1976-03       Impact factor: 11.205

8.  Restricted reassociation of heavy and light chains from hapten-specific monoclonal antibodies.

Authors:  D M Kranz; E W Voss
Journal:  Proc Natl Acad Sci U S A       Date:  1981-09       Impact factor: 11.205

9.  Influenza virus hemagglutinin-specific antibodies isolated from a combinatorial expression library are closely related to the immune response of the donor.

Authors:  A J Caton; H Koprowski
Journal:  Proc Natl Acad Sci U S A       Date:  1990-08       Impact factor: 11.205

10.  Generation of diverse high-affinity human monoclonal antibodies by repertoire cloning.

Authors:  M A Persson; R H Caothien; D R Burton
Journal:  Proc Natl Acad Sci U S A       Date:  1991-03-15       Impact factor: 11.205
  10 in total
  27 in total

1.  Amplification of IgG VH and VL (Fab) from single human plasma cells and B cells.

Authors:  J A Coronella; P Telleman; T D Truong; F Ylera; R P Junghans
Journal:  Nucleic Acids Res       Date:  2000-10-15       Impact factor: 16.971

2.  Expression of a functional antizearalenone single-chain Fv antibody in transgenic Arabidopsis plants.

Authors:  Q Yuan; W Hu; J J Pestka; S Y He; L P Hart
Journal:  Appl Environ Microbiol       Date:  2000-08       Impact factor: 4.792

Review 3.  Recombinant human monoclonal antibodies. Basic principles of the immune system transferred to E. coli.

Authors:  P Fuchs; S Dübel; F Breitling; M Braunagel; I Klewinghaus; M Little
Journal:  Cell Biophys       Date:  1992 Aug-Dec

4.  In-cell PCR from mRNA: amplifying and linking the rearranged immunoglobulin heavy and light chain V-genes within single cells.

Authors:  M J Embleton; G Gorochov; P T Jones; G Winter
Journal:  Nucleic Acids Res       Date:  1992-08-11       Impact factor: 16.971

5.  In vitro selection and affinity maturation of antibodies from a naive combinatorial immunoglobulin library.

Authors:  H Gram; L A Marconi; C F Barbas; T A Collet; R A Lerner; A S Kang
Journal:  Proc Natl Acad Sci U S A       Date:  1992-04-15       Impact factor: 11.205

6.  A phage display approach for rapid antibody humanization: designed combinatorial V gene libraries.

Authors:  C Rader; D A Cheresh; C F Barbas
Journal:  Proc Natl Acad Sci U S A       Date:  1998-07-21       Impact factor: 11.205

7.  A common ancestry for multiple catalytic antibodies generated against a single transition-state analog.

Authors:  H Miyashita; T Hara; R Tanimura; F Tanaka; M Kikuchi; I Fujii
Journal:  Proc Natl Acad Sci U S A       Date:  1994-06-21       Impact factor: 11.205

8.  Propagation of an attenuated virus by design: engineering a novel receptor for a noninfectious foot-and-mouth disease virus.

Authors:  E Rieder; A Berinstein; B Baxt; A Kang; P W Mason
Journal:  Proc Natl Acad Sci U S A       Date:  1996-09-17       Impact factor: 11.205

9.  Recombinant human Fab fragments neutralize human type 1 immunodeficiency virus in vitro.

Authors:  C F Barbas; E Björling; F Chiodi; N Dunlop; D Cababa; T M Jones; S L Zebedee; M A Persson; P L Nara; E Norrby
Journal:  Proc Natl Acad Sci U S A       Date:  1992-10-01       Impact factor: 11.205

10.  Human combinatorial antibody libraries to hepatitis B surface antigen.

Authors:  S L Zebedee; C F Barbas; Y L Hom; R H Caothien; R Graff; J DeGraw; J Pyati; R LaPolla; D R Burton; R A Lerner
Journal:  Proc Natl Acad Sci U S A       Date:  1992-04-15       Impact factor: 11.205
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