Literature DB >> 1373487

Human combinatorial antibody libraries to hepatitis B surface antigen.

S L Zebedee1, C F Barbas, Y L Hom, R H Caothien, R Graff, J DeGraw, J Pyati, R LaPolla, D R Burton, R A Lerner.   

Abstract

Human antibody Fab fragments that bind to hepatitis B surface antigen (HBsAg) were generated by using a recombinant phage surface-display expression system. Characterization of HBsAg-specific Fab fragments isolated from two vaccinated individuals reveals diversity in specificity of antigen binding and in the sequences of the complementarity-determining region. The sequence results show examples of human light-chain promiscuity that result in fine specificity changes and a strong relationship to a human germ-line gene. This application illustrates further that this technique is a powerful tool to isolate distinct human antibodies against immunogenic viral targets.

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Year:  1992        PMID： 1373487      PMCID： PMC48828          DOI： 10.1073/pnas.89.8.3175

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  32 in total

1.  Searching for peptide ligands with an epitope library.

Authors:  J K Scott; G P Smith
Journal:  Science       Date:  1990-07-27       Impact factor: 47.728

2.  Simple, rapid, and quantitative release of periplasmic proteins by chloroform.

Authors:  G F Ames; C Prody; S Kustu
Journal:  J Bacteriol       Date:  1984-12       Impact factor: 3.490

3.  Influenza virus hemagglutinin-specific antibodies isolated from a combinatorial expression library are closely related to the immune response of the donor.

Authors:  A J Caton; H Koprowski
Journal:  Proc Natl Acad Sci U S A       Date:  1990-08       Impact factor: 11.205

4.  A large array of human monoclonal antibodies to type 1 human immunodeficiency virus from combinatorial libraries of asymptomatic seropositive individuals.

Authors:  D R Burton; C F Barbas; M A Persson; S Koenig; R M Chanock; R A Lerner
Journal:  Proc Natl Acad Sci U S A       Date:  1991-11-15       Impact factor: 11.205

5.  Identification of human antibody fragment clones specific for tetanus toxoid in a bacteriophage lambda immunoexpression library.

Authors:  R L Mullinax; E A Gross; J R Amberg; B N Hay; H H Hogrefe; M M Kubitz; A Greener; M Alting-Mees; D Ardourel; J M Short
Journal:  Proc Natl Acad Sci U S A       Date:  1990-10       Impact factor: 11.205

6.  Membrane biogenesis: cotranslational integration of the bacteriophage f1 coat protein into an Escherichia coli membrane fraction.

Authors:  C N Chang; P Model; G Blobel
Journal:  Proc Natl Acad Sci U S A       Date:  1979-03       Impact factor: 11.205

7.  Filamentous fusion phage: novel expression vectors that display cloned antigens on the virion surface.

Authors:  G P Smith
Journal:  Science       Date:  1985-06-14       Impact factor: 47.728

8.  Influenza A virus M2 protein: monoclonal antibody restriction of virus growth and detection of M2 in virions.

Authors:  S L Zebedee; R A Lamb
Journal:  J Virol       Date:  1988-08       Impact factor: 5.103

9.  Generation of diverse high-affinity human monoclonal antibodies by repertoire cloning.

Authors:  M A Persson; R H Caothien; D R Burton
Journal:  Proc Natl Acad Sci U S A       Date:  1991-03-15       Impact factor: 11.205

10.  A conserved human germline V kappa gene directly encodes rheumatoid factor light chains.

Authors:  V Radoux; P P Chen; J A Sorge; D A Carson
Journal:  J Exp Med       Date:  1986-12-01       Impact factor: 14.307
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  31 in total

Review 1.  Generation of recombinant antibodies.

Authors:  S M Kipriyanov; M Little
Journal:  Mol Biotechnol       Date:  1999-09       Impact factor: 2.695

2.  A binary plasmid system for shuffling combinatorial antibody libraries.

Authors:  T A Collet; P Roben; R O'Kennedy; C F Barbas; D R Burton; R A Lerner
Journal:  Proc Natl Acad Sci U S A       Date:  1992-11-01       Impact factor: 11.205

3.  In-cell PCR from mRNA: amplifying and linking the rearranged immunoglobulin heavy and light chain V-genes within single cells.

Authors:  M J Embleton; G Gorochov; P T Jones; G Winter
Journal:  Nucleic Acids Res       Date:  1992-08-11       Impact factor: 16.971

Review 4.  Mining human antibody repertoires.

Authors:  Roger R Beerli; Christoph Rader
Journal:  MAbs       Date:  2010-07-01       Impact factor: 5.857

5.  Biomarker discovery and clinical proteomics.

Authors:  Jerzy Silberring; Pawel Ciborowski
Journal:  Trends Analyt Chem       Date:  2010-02-01       Impact factor: 12.296

6.  Semisynthetic combinatorial antibody libraries: a chemical solution to the diversity problem.

Authors:  C F Barbas; J D Bain; D M Hoekstra; R A Lerner
Journal:  Proc Natl Acad Sci U S A       Date:  1992-05-15       Impact factor: 11.205

Review 7.  Virus-based chemical and biological sensing.

Authors:  Chuanbin Mao; Aihua Liu; Binrui Cao
Journal:  Angew Chem Int Ed Engl       Date:  2009       Impact factor: 15.336

Review 8.  Bacteriophage epitope libraries. The generation of specific binding proteins and peptides in vitro.

Authors:  L M Fink; P L Hsu
Journal:  Virchows Arch       Date:  1994       Impact factor: 4.064

9.  Human monoclonal antibodies against a plethora of viral pathogens from single combinatorial libraries.

Authors:  R A Williamson; R Burioni; P P Sanna; L J Partridge; C F Barbas; D R Burton
Journal:  Proc Natl Acad Sci U S A       Date:  1993-05-01       Impact factor: 11.205

10.  Defining the genetic origins of three rheumatoid synovium-derived IgG rheumatoid factors.

Authors:  M Deftos; T Olee; D A Carson; P P Chen
Journal:  J Clin Invest       Date:  1994-06       Impact factor: 14.808
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