Literature DB >> 17582594

Thymoquinone decreases AGE-induced NF-kappaB activation in proximal tubular epithelial cells.

Ahmed Amir Radwan Sayed1, Michael Morcos.   

Abstract

The inhibitory effects of thymoquinone (TQ) on activation of the redox-sensitive transcription factor nuclear factor kappa B (NF-kappaB) and interleukin-6 (IL-6) were studied in vitro. Human proximal tubular epithelial cells (pTECs) were cultivated and stimulated with advanced glycation end products (AGEs) and the effects of TQ were studied. A significant reduction of AGE-induced NF-kappaB-activation and Il-6 expression was observed. This points to potential antioxidative qualities of TQ.

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Year:  2007        PMID： 17582594     DOI： 10.1002/ptr.2177

Source DB:  PubMed          Journal:  Phytother Res        ISSN： 0951-418X            Impact factor:   5.878


  17 in total

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