Hanieh Shaterzadeh-Yazdi1,2, Mohammad-Foad Noorbakhsh3, Saeed Samarghandian4, Tahereh Farkhondeh5. 1. Research Center of Pardis Hospital, Mashhad, Iran. 2. Nastaran Center for Cancer Prevention, Mashhad, Iran. 3. Division of Pharmacology and Toxicology, Department of Basic Sciences, School of Veterinary Medicine, Shiraz University, Shiraz, Iran. 4. Department of Basic Medical Sciences, Neyshabur University of Medical Sciences, Neyshabur, Iran. 5. Cardiovascular Diseases Research Center, Birjand University of Medical Sciences, Birjand, Iran.
Abstract
BACKGROUND: Kidneys as vital organs remove waste material from blood. Additionally, they may also have a role in the electrolyte balance, regulation of blood pressure, and red blood cell genesis. Kidney diseases may be caused by several factors such as ischemia/reperfusion injury, diabetes, and nephrotoxic agents. Oxidative stress and inflammation are involved in the pathogenesis and progression of kidney diseases. Traditionally, natural antioxidants are used for treatment of renal failure in various countries. SUMMARY: People usually select natural antioxidants since they have an opinion that herbal medicine has not any important side effects. Nigella sativa is a flavoring herb that is widely used as a condiment and as a remedy for many disorders. Thymoquinone (TQ), the most important component of black seeds, mainly oil, is considered as an active agent responsible for a lot of the seed's useful effects. This review describes the protective roles and related mechanisms of TQ against renal disorders. The search terms, including TQ, antioxidant, renal ischemia-reperfusion, diabetic nephropathy, and nephrotoxic agent were searched in scientific databases. TQ showed anti-inflammatory and antioxidant properties in animal and in vitro models of several renal diseases caused by inflammation and oxidative stress. KEY MESSAGES: Experimental studies have shown beneficial effects of TQ against renal diseases; however, well-designed clinical trials in humans are required to confirm these effects.
BACKGROUND: Kidneys as vital organs remove waste material from blood. Additionally, they may also have a role in the electrolyte balance, regulation of blood pressure, and red blood cell genesis. Kidney diseases may be caused by several factors such as ischemia/reperfusion injury, diabetes, and nephrotoxic agents. Oxidative stress and inflammation are involved in the pathogenesis and progression of kidney diseases. Traditionally, natural antioxidants are used for treatment of renal failure in various countries. SUMMARY: People usually select natural antioxidants since they have an opinion that herbal medicine has not any important side effects. Nigella sativa is a flavoring herb that is widely used as a condiment and as a remedy for many disorders. Thymoquinone (TQ), the most important component of black seeds, mainly oil, is considered as an active agent responsible for a lot of the seed's useful effects. This review describes the protective roles and related mechanisms of TQ against renal disorders. The search terms, including TQ, antioxidant, renal ischemia-reperfusion, diabetic nephropathy, and nephrotoxic agent were searched in scientific databases. TQ showed anti-inflammatory and antioxidant properties in animal and in vitro models of several renal diseases caused by inflammation and oxidative stress. KEY MESSAGES: Experimental studies have shown beneficial effects of TQ against renal diseases; however, well-designed clinical trials in humans are required to confirm these effects.
Authors: Jose M Lopez-Novoa; Yaremi Quiros; Laura Vicente; Ana I Morales; Francisco J Lopez-Hernandez Journal: Kidney Int Date: 2010-09-22 Impact factor: 10.612
Authors: Thijs W Cohen Tervaert; Antien L Mooyaart; Kerstin Amann; Arthur H Cohen; H Terence Cook; Cinthia B Drachenberg; Franco Ferrario; Agnes B Fogo; Mark Haas; Emile de Heer; Kensuke Joh; Laure H Noël; Jai Radhakrishnan; Surya V Seshan; Ingeborg M Bajema; Jan A Bruijn Journal: J Am Soc Nephrol Date: 2010-02-18 Impact factor: 10.121
Authors: Marco Cascella; Giuseppe Palma; Antonio Barbieri; Sabrina Bimonte; Nagoth Joseph Amruthraj; Maria Rosaria Muzio; Vitale Del Vecchio; Domenica Rea; Michela Falco; Antonio Luciano; Claudio Arra; Arturo Cuomo Journal: Nutrients Date: 2017-06-17 Impact factor: 5.717
Authors: María Mondéjar-López; Alberto José López-Jiménez; Joaquín C García Martínez; Oussama Ahrazem; Lourdes Gómez-Gómez; Enrique Niza Journal: Int J Mol Sci Date: 2022-01-14 Impact factor: 5.923