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Literature DB >> 17439132

A unified synthetic approach to polyketides having both skeletal and stereochemical diversity.

Shiying Shang¹, Hayato Iwadare, Daniel E Macks, Lisa M Ambrosini, Derek S Tan.

Abstract

An efficient systematic approach to the diversity-oriented synthesis of polyketides has been developed to provide both skeletal and stereochemical diversity. Each synthetic intermediate is also a desired polyketide fragment and no protecting group manipulations are required. A first-generation synthesis provides a 74-membered polyketide library comprising six different skeletal classes, each in one to five steps from propargylic alcohol precursors. A study of epoxyol opening reactions revealed unusual reactivity trends based on epoxide configuration.

Entities: Chemical

Mesh：

Substances：

Year: 2007 PMID： 17439132 PMCID： PMC2597797 DOI： 10.1021/ol070405p

Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005

31 in total

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11 in total

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9. Improved method for the synthesis of beta-carbonyl silyl-1,3-dithianes by the double conjugate addition of 1,3-dithiol to propargylic carbonyl compounds.

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10. Parallel synthesis of an imidazole-4,5-dicarboxamide library bearing amino acid esters and alkanamines.

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