Literature DB >> 10814416

Pairwise use of complexity-generating reactions in diversity-oriented organic synthesis.

D Lee1, J K Sello, S L Schreiber.   

Abstract

[reaction: see text] Two pairs of complexity-generating reactions with an essential product-substrate relationship along a synthetic pathway are demonstrated. This pathway illustrates a key element in a planning algorithm for diversity-oriented synthesis. This element facilitates the efficient synthesis of structurally complex compounds, and it can be integrated with ones that provide structurally diverse compounds.

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Year:  2000        PMID: 10814416     DOI: 10.1021/ol005574n

Source DB:  PubMed          Journal:  Org Lett        ISSN: 1523-7052            Impact factor:   6.005


  26 in total

1.  Euclidean shape-encoded combinatorial chemical libraries.

Authors:  A R Vaino; K D Janda
Journal:  Proc Natl Acad Sci U S A       Date:  2000-07-05       Impact factor: 11.205

2.  Stereochemical control of skeletal diversity.

Authors:  Jason K Sello; Peter R Andreana; Daesung Lee; Stuart L Schreiber
Journal:  Org Lett       Date:  2003-10-30       Impact factor: 6.005

3.  A novel one-pot, four component synthesis of some densely functionalized pyrroles.

Authors:  Javad Azizian; Ali R Karimi; Hamedeh Arefrad; Ali A Mohammadi; M R Mohammadizadeh
Journal:  Mol Divers       Date:  2003       Impact factor: 2.943

4.  Proceedings of the 2nd International Conference on Multi-Component Reactions, Combinatorial and Related Chemistry, Genoa, 14-16 April 2003.

Authors:  Luca Banfi
Journal:  Mol Divers       Date:  2003       Impact factor: 2.943

5.  Recent Advances in the Stereoselective Synthesis of Tetrahydrofurans.

Authors:  John P Wolfe; Michael B Hay
Journal:  Tetrahedron       Date:  2007-01-08       Impact factor: 2.457

Review 6.  Chemical probes and drug leads from advances in synthetic planning and methodology.

Authors:  Christopher J Gerry; Stuart L Schreiber
Journal:  Nat Rev Drug Discov       Date:  2018-04-13       Impact factor: 84.694

7.  Regioselective Domino Metathesis of Unsymmetrical 7-Oxanorbornenes with Electron-Rich Vinyl Acetate toward Biologically Active Glutamate Analogues.

Authors:  Masato Oikawa; Minoru Ikoma; Makoto Sasaki; Martin B Gill; Geoffrey T Swanson; Keiko Shimamoto; Ryuichi Sakai
Journal:  European J Org Chem       Date:  2009-11-01

8.  Re-engineering natural products to engage new biological targets.

Authors:  Stephen E Motika; Paul J Hergenrother
Journal:  Nat Prod Rep       Date:  2020-11-18       Impact factor: 13.423

9.  Bridging the gap between natural product synthesis and drug discovery.

Authors:  Nathanyal J Truax; Daniel Romo
Journal:  Nat Prod Rep       Date:  2020-10-26       Impact factor: 13.423

10.  One-pot synthesis of novel 1-(1H-tetrazol-5-yl)-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine derivatives via an Ugi-azide 4CR process.

Authors:  Mehdi Ghandi; Saleh Salahi; Abuzar Taheri; Alireza Abbasi
Journal:  Mol Divers       Date:  2017-12-11       Impact factor: 2.943

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