Literature DB >> 17368024

Imidazo[1,2-a]pyridines with potent activity against herpesviruses.

Kristjan S Gudmundsson1, Brian A Johns.   

Abstract

Synthesis of a series of 2-aryl-3-pyrimidyl-imidazo[1,2-a]pyridines with potent activity against herpes simplex viruses is described. Synthetic approaches allowing for variation of the 2-aryl, 3-heteroaryl as well as other imidazopyridine substituents are outlined and resulting effects on antiviral activity are highlighted. Several compounds with in vitro antiviral activity similar or better than acyclovir are described.

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Year:  2007        PMID： 17368024     DOI： 10.1016/j.bmcl.2007.02.079

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  11 in total

1.  One-pot synthesis of 2-phenylimidazo[1,2-α]pyridines from acetophenone, [Bmim]Br(3) and 2-aminopyridine under solvent-free conditions.

Authors:  Zhang-Gao Le; Zong-Bo Xie; Jian-Ping Xu
Journal:  Molecules       Date:  2012-11-09       Impact factor: 4.411

2.  Metal-free, efficient hydrazination of imidazo[1,2-a]pyridine with diethyl azodicarboxylate in neutral media.

Authors:  Yuanxiang Wang; Brendan Frett; Nick McConnell; Hong-Yu Li
Journal:  Org Biomol Chem       Date:  2015-03-14       Impact factor: 3.876

3.  BF3-etherate promoted facile access to vinyloxyimidazopyridines: a metal-free sustainable approach.

Authors:  Saurabh Kumar Tiwari; Mohd Nazeef; Ankit Verma; Ankit Kumar; Vikas Yadav; Neetu Yadav; Saif Ansari; I R Siddiqui
Journal:  Mol Divers       Date:  2021-05-16       Impact factor: 2.943

4.  2-Methyl-6-(trifluoro-meth-yl)imidazo[1,2-a]pyridine-3-carbonitrile.

Authors:  Hoong-Kun Fun; Mohd Mustaqim Rosli; D J Madhu Kumar; D Jagadeesh Prasad; G K Nagaraja
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2011-02-05

5.  2-(8-Bromo-imidazo[1,2-a]pyridin-2-yl)-N'-[(E)-4-diethyl-amino-2-hy-droxy-benzyl-idene]acetohydrazide dihydrate.

Authors:  Hoong-Kun Fun; Wan-Sin Loh; Seema Shenvi; Arun M Isloor; Gurumurthy Hegde
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2012-02-24

6.  Chemical-genetic profiling of imidazo[1,2-a]pyridines and -pyrimidines reveals target pathways conserved between yeast and human cells.

Authors:  Lisa Yu; Andres Lopez; Abderrahmane Anaflous; Brahim El Bali; Abdellah Hamal; Elke Ericson; Lawrence E Heisler; Angus McQuibban; Guri Giaever; Corey Nislow; Charles Boone; Grant W Brown; Mohammed Bellaoui
Journal:  PLoS Genet       Date:  2008-11-28       Impact factor: 5.917

7.  Efficient access to 2,3-diarylimidazo[1,2-a]pyridines via a one-pot, ligand-free, palladium-catalyzed three-component reaction under microwave irradiation.

Authors:  Yuanxiang Wang; Brendan Frett; Hong-yu Li
Journal:  Org Lett       Date:  2014-05-22       Impact factor: 6.005

8.  Inhibition of inflammation and oxidative stress by an imidazopyridine derivative X22 prevents heart injury from obesity.

Authors:  Yuanyuan Qian; Yali Zhang; Peng Zhong; Kesong Peng; Zheng Xu; Xuemei Chen; Kongqin Lu; Gaozhi Chen; Xiaokun Li; Guang Liang
Journal:  J Cell Mol Med       Date:  2016-03-28       Impact factor: 5.310

9.  New tricks of well-known aminoazoles in isocyanide-based multicomponent reactions and antibacterial activity of the compounds synthesized.

Authors:  Maryna V Murlykina; Maryna N Kornet; Sergey M Desenko; Svetlana V Shishkina; Oleg V Shishkin; Aleksander A Brazhko; Vladimir I Musatov; Erik V Van der Eycken; Valentin A Chebanov
Journal:  Beilstein J Org Chem       Date:  2017-05-31       Impact factor: 2.883

10.  Structural characterization and Hirshfeld surface analysis of a CoII complex with imidazo[1,2-a]pyridine.

Authors:  Saikat Kumar Seth
Journal:  Acta Crystallogr E Crystallogr Commun       Date:  2018-04-17
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