Literature DB >> 1731118

Ribosomal frameshifting requires a pseudoknot in the Saccharomyces cerevisiae double-stranded RNA virus.

T H Tzeng1, C L Tu, J A Bruenn.   

Abstract

The large double-stranded RNA of the Saccharomyces cerevisiae (yeast) virus has two large overlapping open reading frames on the plus strand, one of which is translated via a -1 ribosomal frameshift. Sequences including the overlapping region, placed in novel contexts, can direct ribosomes to make a -1 frameshift in wheat germ extract, Escherichia coli and S. cerevisiae. This sequence includes a consensus slippery sequence, GGGUUUA, and has the potential to form a pseudoknot 3' to the putative frameshift site. Based on deletion analysis, a region of 71 nucleotides including the potential pseudoknot and the putative slippery sequence is sufficient for frameshifting. Site-directed mutagenesis demonstrates that the pseudoknot is essential for frameshifting.

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Year:  1992        PMID： 1731118      PMCID： PMC240802     

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  35 in total

1.  Nucleotide sequence of a yeast Ty element: evidence for an unusual mechanism of gene expression.

Authors:  J Clare; P Farabaugh
Journal:  Proc Natl Acad Sci U S A       Date:  1985-05       Impact factor: 11.205

2.  Two efficient ribosomal frameshifting events are required for synthesis of mouse mammary tumor virus gag-related polyproteins.

Authors:  T Jacks; K Townsley; H E Varmus; J Majors
Journal:  Proc Natl Acad Sci U S A       Date:  1987-06       Impact factor: 11.205

3.  HIV expression strategies: ribosomal frameshifting is directed by a short sequence in both mammalian and yeast systems.

Authors:  W Wilson; M Braddock; S E Adams; P D Rathjen; S M Kingsman; A J Kingsman
Journal:  Cell       Date:  1988-12-23       Impact factor: 41.582

Review 4.  RNA pseudoknots that interact with components of the translation apparatus.

Authors:  P Schimmel
Journal:  Cell       Date:  1989-07-14       Impact factor: 41.582

5.  A new principle of RNA folding based on pseudoknotting.

Authors:  C W Pleij; K Rietveld; L Bosch
Journal:  Nucleic Acids Res       Date:  1985-03-11       Impact factor: 16.971

6.  RNA pseudoknots. Stability and loop size requirements.

Authors:  J R Wyatt; J D Puglisi; I Tinoco
Journal:  J Mol Biol       Date:  1990-07-20       Impact factor: 5.469

7.  Expression of calf prochymosin in Saccharomyces cerevisiae.

Authors:  C G Goff; D T Moir; T Kohno; T C Gravius; R A Smith; E Yamasaki; A Taunton-Rigby
Journal:  Gene       Date:  1984-01       Impact factor: 3.688

8.  RNA pseudoknots: translational frameshifting and readthrough on viral RNAs.

Authors:  E B ten Dam; C W Pleij; L Bosch
Journal:  Virus Genes       Date:  1990-07       Impact factor: 2.332

9.  Ribosomal frameshifting in the yeast retrotransposon Ty: tRNAs induce slippage on a 7 nucleotide minimal site.

Authors:  M F Belcourt; P J Farabaugh
Journal:  Cell       Date:  1990-07-27       Impact factor: 41.582

10.  Signals for ribosomal frameshifting in the Rous sarcoma virus gag-pol region.

Authors:  T Jacks; H D Madhani; F R Masiarz; H E Varmus
Journal:  Cell       Date:  1988-11-04       Impact factor: 41.582
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  34 in total

1.  Specific mutations in a viral RNA pseudoknot drastically change ribosomal frameshifting efficiency.

Authors:  Y G Kim; L Su; S Maas; A O'Neill; A Rich
Journal:  Proc Natl Acad Sci U S A       Date:  1999-12-07       Impact factor: 11.205

2.  Kinetics of ribosomal pausing during programmed -1 translational frameshifting.

Authors:  J D Lopinski; J D Dinman; J A Bruenn
Journal:  Mol Cell Biol       Date:  2000-02       Impact factor: 4.272

3.  Cloning and characterization of a totivirus double-stranded RNA from the plant pathogenic fungus, Helicobasidium mompa Tanaka.

Authors:  Kinya Nomura; Hideki Osaki; Toru Iwanami; Naoyuki Matsumoto; Yoshihiro Ohtsu
Journal:  Virus Genes       Date:  2003-05       Impact factor: 2.332

4.  A -1 ribosomal frameshift element that requires base pairing across four kilobases suggests a mechanism of regulating ribosome and replicase traffic on a viral RNA.

Authors:  Jennifer K Barry; W Allen Miller
Journal:  Proc Natl Acad Sci U S A       Date:  2002-07-30       Impact factor: 11.205

5.  Ribosomal movement impeded at a pseudoknot required for frameshifting.

Authors:  C Tu; T H Tzeng; J A Bruenn
Journal:  Proc Natl Acad Sci U S A       Date:  1992-09-15       Impact factor: 11.205

6.  Unique double-stranded RNAs responsible for the anti-Candida activity of the yeast Hanseniaspora uvarum.

Authors:  M J Schmitt; O Poravou; K Trenz; K Rehfeldt
Journal:  J Virol       Date:  1997-11       Impact factor: 5.103

Review 7.  Programmed translational frameshifting.

Authors:  P J Farabaugh
Journal:  Microbiol Rev       Date:  1996-03

8.  Relationships and Evolution of Double-Stranded RNA Totiviruses of Yeasts Inferred from Analysis of L-A-2 and L-BC Variants in Wine Yeast Strain Populations.

Authors:  Nieves Rodríguez-Cousiño; Rosa Esteban
Journal:  Appl Environ Microbiol       Date:  2017-02-01       Impact factor: 4.792

9.  Killer toxin-secreting double-stranded RNA mycoviruses in the yeasts Hanseniaspora uvarum and Zygosaccharomyces bailii.

Authors:  M J Schmitt; F Neuhausen
Journal:  J Virol       Date:  1994-03       Impact factor: 5.103

10.  Decreased peptidyltransferase activity correlates with increased programmed -1 ribosomal frameshifting and viral maintenance defects in the yeast Saccharomyces cerevisiae.

Authors:  Arturas Meskauskas; Jason W Harger; Kristi L Muldoon Jacobs; Jonathan D Dinman
Journal:  RNA       Date:  2003-08       Impact factor: 4.942
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