Literature DB >> 17067167

Phenolic marine natural products as aldose reductase inhibitors.

Sonia Manzanaro1, Javier Salva, Jesús Angel de la Fuente.   

Abstract

Four different types of marine natural compounds isolated from tunicates were found to inhibit human aldose reductase. They all are characterized by a heterocyclic system, and at least two phenolic groups are present in the structure. Two of the compounds tested showed an inhibitory potency 5/6-fold higher than that of the known AR inhibitor sorbinil. One notable structural feature of these active compounds is the lack of either the carboxylic acid or the spiro-hydantoin commonly present in the principal classes of currently used inhibitors.

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Year:  2006        PMID： 17067167     DOI： 10.1021/np0503698

Source DB:  PubMed          Journal:  J Nat Prod        ISSN： 0163-3864            Impact factor:   4.050


  13 in total

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Review 9.  Natural Products Diversity of Marine Ascidians (Tunicates; Ascidiacea) and Successful Drugs in Clinical Development.

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Journal:  Nat Prod Bioprospect       Date:  2017-01-17

10.  Inhibitory effects of Colocasia esculenta (L.) Schott constituents on aldose reductase.

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Journal:  Molecules       Date:  2014-08-27       Impact factor: 4.411
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