BACKGROUND: The review presents the 2005-2006 peer-reviewed marine pharmacology literature, and follows a similar format to the authors' 1998-2004 reviews. The preclinical pharmacology of chemically characterized marine compounds isolated from marine animals, algae, fungi and bacteria is systematically presented. RESULTS: Anthelmintic, antibacterial, anticoagulant, antifungal, antimalarial, antiprotozoal, antituberculosis and antiviral activities were reported for 78 marine chemicals. Additionally 47 marine compounds were reported to affect the cardiovascular, immune and nervous system as well as possess anti-inflammatory effects. Finally, 58 marine compounds were shown to bind to a variety of molecular targets, and thus could potentially contribute to several pharmacological classes. CONCLUSIONS: Marine pharmacology research during 2005-2006 was truly global in nature, involving investigators from 32 countries, and the United States, and contributed 183 marine chemical leads to the research pipeline aimed at the discovery of novel therapeutic agents. GENERAL SIGNIFICANCE: Continued preclinical and clinical research with marine natural products demonstrating a broad spectrum of pharmacological activity will probably result in novel therapeutic agents for the treatment of multiple disease categories.
pan class="abstract_title">BACKGROUND: The review presents the 2005-2006 peer-reviewed marine pharmacology literature, and follows a similar format to the authors' 1998-2004 reviews. The preclinical pharmacology of chemically characterized marine compounds isolated from marine animals, span> class="Species">algae, fungi and bacteria is systematically presented. RESULTS: Anthelmintic, antibacterial, anticoagulant, antifungal, antimalarial, antiprotozoal, antituberculosis and antiviral activities were reported for 78 marine chemicals. Additionally 47 marine compounds were reported to affect the cardiovascular, immune and nervous system as well as possess anti-inflammatory effects. Finally, 58 marine compounds were shown to bind to a variety of molecular targets, and thus could potentially contribute to several pharmacological classes. CONCLUSIONS: Marine pharmacology research during 2005-2006 was truly global in nature, involving investigators from 32 countries, and the United States, and contributed 183 marine chemical leads to the research pipeline aimed at the discovery of novel therapeutic agents. GENERAL SIGNIFICANCE: Continued preclinical and clinical research with marine natural products demonstrating a broad spectrum of pharmacological activity will probably result in novel therapeutic agents for the treatment of multiple disease categories.
Authors: Marion Loughnan; Annette Nicke; Alun Jones; Christina I Schroeder; Simon T Nevin; David J Adams; Paul F Alewood; Richard J Lewis Journal: J Biol Chem Date: 2006-06-21 Impact factor: 5.157
Authors: Claudia A Ospina; Abimael D Rodríguez; Juan A Sánchez; Eduardo Ortega-Barria; Todd L Capson; Alejandro M S Mayer Journal: J Nat Prod Date: 2005-10 Impact factor: 4.050
Authors: Utpal Adhikari; Cecilia G Mateu; Kausik Chattopadhyay; Carlos A Pujol; Elsa B Damonte; Bimalendu Ray Journal: Phytochemistry Date: 2006-11 Impact factor: 4.072
Authors: Betty Matsuhiro; Ana F Conte; Elsa B Damonte; Adriana A Kolender; María C Matulewicz; Enrique G Mejías; Carlos A Pujol; Elisa A Zúñiga Journal: Carbohydr Res Date: 2005-10-31 Impact factor: 2.104
Authors: Francis Robert; Hong Qing Gao; Marwa Donia; William C Merrick; Mark T Hamann; Jerry Pelletier Journal: RNA Date: 2006-03-15 Impact factor: 4.942
Authors: Roya Zoraghi; Liam Worrall; Raymond H See; Wendy Strangman; Wendy L Popplewell; Huansheng Gong; Toufiek Samaai; Richard D Swayze; Sukhbir Kaur; Marija Vuckovic; B Brett Finlay; Robert C Brunham; William R McMaster; Michael T Davies-Coleman; Natalie C Strynadka; Raymond J Andersen; Neil E Reiner Journal: J Biol Chem Date: 2011-10-26 Impact factor: 5.157