Literature DB >> 1688707

Serotonergic effects of isatin: an endogenous MAO inhibitor related to tribulin.

I M McIntyre1, T R Norman.   

Abstract

A study of the acute effects of isatin, an endogenous MAO inhibitor related to tribulin, on rat brain serotonergic function was undertaken. A single dose of isatin significantly increased 5-HT concentrations in the hypothalamus and cortex but did not significantly alter 5-HIAA concentrations. Synaptosomal 5-HT uptake was unaffected but there was a trend for the number of 3H-ketanserin binding sites was to be decreased. The results of the study are discussed in terms of the relationship of isatin to tribulin and their possible causal role in stress.

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Year:  1990        PMID： 1688707     DOI： 10.1007/bf01250998

Source DB:  PubMed          Journal:  J Neural Transm Gen Sect


  14 in total

1.  Central serotonin receptors: effector systems, physiological roles and regulation.

Authors:  P J Conn; E Sanders-Bush
Journal:  Psychopharmacology (Berl)       Date:  1987       Impact factor: 4.530

2.  Distribution of endogenous benzodiazepine receptor ligand-monoamine oxidase inhibitory activity (tribulin) in tissues.

Authors:  I Armando; V Glover; M Sandler
Journal:  Life Sci       Date:  1986-06-02       Impact factor: 5.037

3.  Benzodiazepines reduce stress-augmented increase in rat urine monoamine oxidase inhibitor.

Authors:  V Glover; S K Bhattacharya; M Sandler; S E File
Journal:  Nature       Date:  1981-07-23       Impact factor: 49.962

4.  A practical computer-based approach to the analysis of radioligand binding experiments.

Authors:  G A McPherson
Journal:  Comput Programs Biomed       Date:  1983 Aug-Oct

5.  Serotonin receptor sensitivity after acute and chronic treatment with mianserin.

Authors:  M A Blackshear; E Sanders-Bush
Journal:  J Pharmacol Exp Ther       Date:  1982-05       Impact factor: 4.030

6.  A monoamine oxidase inhibitor in human urine.

Authors:  V Glover; M A Reveley; M Sandler
Journal:  Biochem Pharmacol       Date:  1980-02       Impact factor: 5.858

7.  Stress-induced synthesis of melatonin: possible involvement of the endogenous monoamine oxidase inhibitor (tribulin).

Authors:  G F Oxenkrug; I M McIntyre
Journal:  Life Sci       Date:  1985-11-04       Impact factor: 5.037

8.  Multiple serotonin receptors: regional distribution and effect of Raphe lesions.

Authors:  M A Blackshear; L R Steranka; E Sanders-Bush
Journal:  Eur J Pharmacol       Date:  1981-12-17       Impact factor: 4.432

9.  Isatin: identity with the purified endogenous monoamine oxidase inhibitor tribulin.

Authors:  V Glover; J M Halket; P J Watkins; A Clow; B L Goodwin; M Sandler
Journal:  J Neurochem       Date:  1988-08       Impact factor: 5.372

10.  Effect of isatin (2,3 dioxoindoline) on physiological and pathological electrographic manifestations and vigilance.

Authors:  L Chocholová; M Kolinová
Journal:  Physiol Bohemoslov       Date:  1981
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  6 in total

1.  The effect of isatin (tribulin) on metabolism of indoles in the rat brain and pineal: in vitro and in vivo studies.

Authors:  A Yuwiler
Journal:  Neurochem Res       Date:  1990-01       Impact factor: 3.996

Review 2.  Exploration of the Detailed Structure-Activity Relationships of Isatin and Their Isomers As Monoamine Oxidase Inhibitors.

Authors:  Sunil Kumar; Aathira Sujathan Nair; Mohamed A Abdelgawad; Bijo Mathew
Journal:  ACS Omega       Date:  2022-05-05

3.  Effects of muscarinic receptor agonists and antagonists on rat brain serotonergic activity.

Authors:  S K Bhattacharya; A P Sen
Journal:  J Neural Transm Gen Sect       Date:  1992

4.  Synthesis of Substituted Isatins.

Authors:  Larry L Klein; Michael D Tufano
Journal:  Tetrahedron Lett       Date:  2012-12-21       Impact factor: 2.415

5.  Pharmacological Modulation of Serotonin Levels in Zebrafish Larvae: Lessons for Identifying Environmental Neurotoxicants Targeting the Serotonergic System.

Authors:  Melissa Faria; Eva Prats; Marina Bellot; Cristian Gomez-Canela; Demetrio Raldúa
Journal:  Toxics       Date:  2021-05-25

6.  Isatin, an endogenous MAO inhibitor, and a rat model of Parkinson's disease induced by the Japanese encephalitis virus.

Authors:  M Minami; N Hamaue; M Hirafuji; H Saito; T Hiroshige; A Ogata; K Tashiro; S H Parvez
Journal:  J Neural Transm Suppl       Date:  2006
  6 in total

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