| Literature DB >> 3392550 |
V Glover1, J M Halket, P J Watkins, A Clow, B L Goodwin, M Sandler.
Abstract
Purified tribulin, an endogenous monoamine oxidase (MAO) inhibitor, has been identified by direct probe insertion mass spectrometry as the indole-2,3-dione, isatin. A gas chromatographic-mass spectrometric assay for isatin has been developed and used to measure its relatively high concentrations in unpurified human urine, and in rat heart and brain. Isatin is a known compound with a broad range of biological activity; this is the first report of its presence in the animal body. Isatin is a potent inhibitor of MAO, particularly of MAO B (IC50, 3 microM), and also binds to central benzodiazepine receptors (IC50 against clonazepam, 123 microM).Entities:
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Year: 1988 PMID： 3392550 DOI： 10.1111/j.1471-4159.1988.tb01089.x
Source DB: PubMed Journal: J Neurochem ISSN： 0022-3042 Impact factor: 5.372