Literature DB >> 179098

Differential effect of phosphonoacetic acid on the expression of Epstein-Barr viral antigens and virus production.

O Nyormoi, D A Thorley-Lawson, J Elkington, J L Strominger.   

Abstract

The effects of phosphonoacetic acid on cell growth, expression of Epstein-Barr virus antigens, and virus production in human and marmoset lymphoblastoid cell lines have been studied. The drug had no significant effect at concentrations up to 100 mug/ml on cell growth or total cell DNA synthesis. Higher doses induced not only a drastic decrease in DNA synthesis and cell grwoth, but also a dramatic cell enlargement. Immunofluorescence studies showed that greater than or equal to 30 mug/ml of phosphonoacetic acid inhibited viral capsid antigen synthesis without affecting the expression of the nuclear antigen or the spontaneous and 5-iodo-2'-deoxyuridine-induced early antigens. Production of transforming Epstein-Barr virus was also blocked.

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Year:  1976        PMID： 179098      PMCID： PMC430377          DOI： 10.1073/pnas.73.5.1745

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  22 in total

1.  Isolation of herpes simplex virus clones and drug resistant mutants in microcultures.

Authors:  R J Klein
Journal:  Arch Virol       Date:  1975       Impact factor: 2.574

2.  Phosphonoacetic acid-resistant herpes simplex virus infection in hairless mice.

Authors:  R J Klein; A E Friedman-Kien
Journal:  Antimicrob Agents Chemother       Date:  1975-03       Impact factor: 5.191

3.  Assay for Epstein-Barr virus based on stimulation of DNA synthesis in mixed leukocytes from human umbilical cord blood.

Authors:  J Robinson
Journal:  J Virol       Date:  1975-05       Impact factor: 5.103

4.  Immunofluorescence in cells derived from Burkitt's lymphoma.

Authors:  G Henle; W Henle
Journal:  J Bacteriol       Date:  1966-03       Impact factor: 3.490

5.  Cloning of immunoglobulin-producing human leukemic and lymphoma cells in long-term cultures.

Authors:  Y Hinuma; J T Grace
Journal:  Proc Soc Exp Biol Med       Date:  1967-01

6.  Cellular localization of an Epstein-Barr virus (EBV)-associated complement-fixing antigen in producer and non-producer lymphoblastoid cell lines.

Authors:  B M Reedman; G Klein
Journal:  Int J Cancer       Date:  1973-05       Impact factor: 7.396

7.  New technique for distinguishing between human chromosomes.

Authors:  A T Sumner; H J Evans; R A Buckland
Journal:  Nat New Biol       Date:  1971-07-07

8.  Synthesis of herpes simplex virus, vaccinia virus, and adenovirus DNA in isolated HeLa cell nuclei. I. Effect of viral-specific antisera and phosphonoacetic acid.

Authors:  A Bolden; J Aucker; A Weissbach
Journal:  J Virol       Date:  1975-12       Impact factor: 5.103

9.  Human cytomegalovirus. IV. Specific inhibition of virus-induced DNA polymerase activity and viral DNA replication by phosphonoacetic acid.

Authors:  E S Huang
Journal:  J Virol       Date:  1975-12       Impact factor: 5.103

10.  Mechanism of phosphonoacetate inhibition of herpesvirus-induced DNA polymerase.

Authors:  S S Leinbach; J M Reno; L F Lee; A F Isbell; J A Boezi
Journal:  Biochemistry       Date:  1976-01-27       Impact factor: 3.162
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  19 in total

1.  Effects of adenine arabinoside on lymphocytes infected with Epstein-Barr virus.

Authors:  W C Benz; P J Siegel; J Baer
Journal:  J Virol       Date:  1978-09       Impact factor: 5.103

2.  Cytofluorometry of lymphocytes infected with Epstein-Barr virus: effect of phosphonoacetic acid on nucleic acid.

Authors:  S M Lemon; L M Hutt; J S Pagano
Journal:  J Virol       Date:  1978-01       Impact factor: 5.103

3.  Effects of nucleoside analogs on Epstein-Barr virus-induced transformation of human umbilical cord leukocytes and Epstein-Barr virus expression in transformed cells.

Authors:  E E Henderson; W K Long; R Ribecky
Journal:  Antimicrob Agents Chemother       Date:  1979-01       Impact factor: 5.191

4.  Upregulation of STAT3 marks Burkitt lymphoma cells refractory to Epstein-Barr virus lytic cycle induction by HDAC inhibitors.

Authors:  Derek Daigle; Cynthia Megyola; Ayman El-Guindy; Lyn Gradoville; David Tuck; George Miller; Sumita Bhaduri-McIntosh
Journal:  J Virol       Date:  2009-11-04       Impact factor: 5.103

5.  Identification and mapping of polypeptides encoded by the P3HR-1 strain of Epstein-Barr virus.

Authors:  L K Cohen; S H Speck; B E Roberts; J L Strominger
Journal:  Proc Natl Acad Sci U S A       Date:  1984-07       Impact factor: 11.205

6.  Sedimentation characteristics of newly synthesized Epstein-Barr viral DNA in superinfected cells.

Authors:  P J Siegel; W Clough; J L Strominger
Journal:  J Virol       Date:  1981-06       Impact factor: 5.103

7.  Epstein-Barr virus BALF3 has nuclease activity and mediates mature virion production during the lytic cycle.

Authors:  Shih-Hsin Chiu; Meng-Chuan Wu; Chung-Chun Wu; Yu-Ching Chen; Su-Fang Lin; John T-A Hsu; Chung-Shi Yang; Ching-Hwa Tsai; Kenzo Takada; Mei-Ru Chen; Jen-Yang Chen
Journal:  J Virol       Date:  2014-02-19       Impact factor: 5.103

8.  Immunobiochemical characterization with monoclonal antibodies of Epstein-Barr virus-associated early antigens in chemically induced cells.

Authors:  A L Epstein
Journal:  J Virol       Date:  1984-05       Impact factor: 5.103

9.  p105, an Epstein-Barr virus-induced, phosphonoacetic acid-insensitive glycoprotein target of the anti-Epstein-Barr virus immune response.

Authors:  D Casareale; W Jones; T Sairenji; R E Humphreys
Journal:  Infect Immun       Date:  1983-01       Impact factor: 3.441

10.  Immune response and latent infection after topical treatment of herpes simplex virus infection in hairless mice.

Authors:  R J Klein; A E Friedman-Kien; A A Fondak; E Buimovici-Klein
Journal:  Infect Immun       Date:  1977-06       Impact factor: 3.441
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