| Literature DB >> 16759871 |
Yuxiang Dong1, Yuanqing Tang, Jacques Chollet, Hugues Matile, Sergio Wittlin, Susan A Charman, William N Charman, Josefina Santo Tomas, Christian Scheurer, Christopher Snyder, Bernard Scorneaux, Saroj Bajpai, Scott A Alexander, Xiaofang Wang, Maniyan Padmanilayam, Srinivasa R Cheruku, Reto Brun, Jonathan L Vennerstrom.
Abstract
Based on the structures of several lipophilic trioxolane antimalarial prototypes, we set out to determine which functional groups were associated with good antimalarial profiles and identify more polar (lower LogP/LogD) lead compounds with good physicochemical properties. More lipophilic trioxolanes tended to have better oral activities than their more polar counterparts. Trioxolanes with a wide range of neutral and basic, but not acidic, functional groups had good antimalarial profiles.Entities:
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Year: 2006 PMID： 16759871 DOI： 10.1016/j.bmc.2006.05.041
Source DB: PubMed Journal: Bioorg Med Chem ISSN： 0968-0896 Impact factor: 3.641