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Literature DB >> 23432396

The lipophilic bullet hits the targets: medicinal chemistry of adamantane derivatives.

Lukas Wanka¹, Khalid Iqbal, Peter R Schreiner.

Abstract

Entities: Chemical

Mesh：

Substances：

Year: 2013 PMID： 23432396 PMCID： PMC3650105 DOI： 10.1021/cr100264t

Source DB: PubMed Journal: Chem Rev ISSN： 0009-2665 Impact factor: 60.622

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793 in total

Review 1. [Structure, function and potential therapeutic possibilities of NMDA receptors. 2. Therapy concepts and new receptor ligands].

Authors: H Stark; U Reichert; S Grassmann
Journal: Pharm Unserer Zeit Date: 2000-07

2. Reversion of influenza A (H3N2) virus from amantadine resistant to amantadine sensitive by further reassortment in Japan during the 2006-to-2007 influenza season.

Authors: Yuki Furuse; Akira Suzuki; Taro Kamigaki; Midori Shimizu; Naoko Fuji; Hitoshi Oshitani
Journal: J Clin Microbiol Date: 2008-12-24 Impact factor: 5.948

3. Mg2+ imparts NMDA receptor subtype selectivity to the Alzheimer's drug memantine.

Authors: Shawn E Kotermanski; Jon W Johnson
Journal: J Neurosci Date: 2009-03-04 Impact factor: 6.167

4. Inhibition of mitochondrial respiration as a source of adaphostin-induced reactive oxygen species and cytotoxicity.

Authors: Son B Le; M Katie Hailer; Sarah Buhrow; Qi Wang; Karen Flatten; Peter Pediaditakis; Keith C Bible; Lionel D Lewis; Edward A Sausville; Yuan-Ping Pang; Matthew M Ames; John J Lemasters; Ekhson L Holmuhamedov; Scott H Kaufmann
Journal: J Biol Chem Date: 2007-01-09 Impact factor: 5.157

5. Antiviral agents. I. Bicyclo [2.2.2] octan- and -oct-2-enamines.

Authors: J G Whitney; W A Gregory; J C Kauer; J R Roland; J A Snyder; R E Benson; E C Hermann
Journal: J Med Chem Date: 1970-03 Impact factor: 7.446

6. Inhibition of hepatitis A virus replication in vitro by antiviral compounds.

Authors: J M Crance; E Biziagos; J Passagot; H van Cuyck-Gandré; R Deloince
Journal: J Med Virol Date: 1990-06 Impact factor: 2.327

Review 7. Memantine: a NMDA receptor antagonist that improves memory by restoration of homeostasis in the glutamatergic system--too little activation is bad, too much is even worse.

Authors: Chris G Parsons; Albrecht Stöffler; Wojciech Danysz
Journal: Neuropharmacology Date: 2007-08-10 Impact factor: 5.250

8. Adamantyl-substituted retinoid-derived molecules that interact with the orphan nuclear receptor small heterodimer partner: effects of replacing the 1-adamantyl or hydroxyl group on inhibition of cancer cell growth, induction of cancer cell apoptosis, and inhibition of SRC homology 2 domain-containing protein tyrosine phosphatase-2 activity.

Authors: Marcia I Dawson; Zebin Xia; Tao Jiang; Mao Ye; Joseph A Fontana; Lulu Farhana; Bhaumik Patel; Li Ping Xue; Mohammad Bhuiyan; Roberto Pellicciari; Antonio Macchiarulo; Roberto Nuti; Xiao-Kun Zhang; Young-Hoon Han; Lutz Tautz; Peter D Hobbs; Ling Jong; Nahid Waleh; Wan-Ru Chao; Gen-Sheng Feng; Yuhong Pang; Ying Su
Journal: J Med Chem Date: 2008-08-30 Impact factor: 7.446

9. Treatment of acute herpes zoster with amantadine hydrochloride (Symmetrel).

Authors: A W Galbraith
Journal: Br Med J Date: 1973-12-22

10. From nature to the laboratory and into the clinic.

Authors: K C Nicolaou; Jason S Chen; Stephen M Dalby
Journal: Bioorg Med Chem Date: 2008-11-06 Impact factor: 3.641

63 in total

1. Effects of adamantane alterations on soluble epoxide hydrolase inhibition potency, physical properties and metabolic stability.

Authors: Vladimir Burmistrov; Christophe Morisseau; Todd R Harris; Gennady Butov; Bruce D Hammock
Journal: Bioorg Chem Date: 2017-12-30 Impact factor: 5.275

The lipophilic bullet hits the targets: medicinal chemistry of adamantane derivatives.

Review 1. [Structure, function and potential therapeutic possibilities of NMDA receptors. 2. Therapy concepts and new receptor ligands].

2. Reversion of influenza A (H3N2) virus from amantadine resistant to amantadine sensitive by further reassortment in Japan during the 2006-to-2007 influenza season.

3. Mg2+ imparts NMDA receptor subtype selectivity to the Alzheimer's drug memantine.

4. Inhibition of mitochondrial respiration as a source of adaphostin-induced reactive oxygen species and cytotoxicity.

5. Antiviral agents. I. Bicyclo [2.2.2] octan- and -oct-2-enamines.

6. Inhibition of hepatitis A virus replication in vitro by antiviral compounds.

Review 7. Memantine: a NMDA receptor antagonist that improves memory by restoration of homeostasis in the glutamatergic system--too little activation is bad, too much is even worse.

9. Treatment of acute herpes zoster with amantadine hydrochloride (Symmetrel).

10. From nature to the laboratory and into the clinic.

1. Effects of adamantane alterations on soluble epoxide hydrolase inhibition potency, physical properties and metabolic stability.

2. Inhibition of IκB kinase-β and IκB kinase-α by heterocyclic adamantyl arotinoids.

3. Light-triggered CO delivery by a water-soluble and biocompatible manganese photoCORM.

4. In vitro antiproliferative study of novel adamantyl pyridin-4-ones.

5. Sesquiterpenoids and xanthones derivatives produced by sponge-derived fungus Stachybotry sp. HH1 ZSDS1F1-2.

6. The role of a diamondoid as a hydrogen donor or acceptor in probing DNA nucleobases.

7. A Super Strong Engineered Auxin-TIR1 Pair.

Review 8. Hydrophilic carbon clusters as therapeutic, high-capacity antioxidants.

9. Synthesis of amino-diamondoid pharmacophores via photocatalytic C-H aminoalkylation.

10. Catalyst-free multicomponent synthesis of novel adamantyl-containing tetrahydropyrimidine carboxylates.