Literature DB >> 22106214

In vivo activity of aryl ozonides against Schistosoma species.

Jennifer Keiser1, Katrin Ingram, Mireille Vargas, Jacques Chollet, Xiaofang Wang, Yuxiang Dong, Jonathan L Vennerstrom.   

Abstract

We evaluated the in vivo antischistosomal activities of 11 structurally diverse synthetic peroxides. Of all compounds tested, ozonide (1,2,4-trioxolane) OZ418 had the highest activity against adult Schistosoma mansoni, with total and female worm burden reductions of 80 and 90% (P < 0.05), respectively. Furthermore, treatment of S. haematobium-infected mice with OZ418 reduced the total worm burden by 86%. In conclusion, OZ418 is a promising antischistosomal lead compound.

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Year:  2011        PMID： 22106214      PMCID： PMC3264258          DOI： 10.1128/AAC.05371-11

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  18 in total

1.  In vitro activities of trioxaquines against Schistosoma mansoni.

Authors:  Jérôme Boissier; Frédéric Coslédan; Anne Robert; Bernard Meunier
Journal:  Antimicrob Agents Chemother       Date:  2009-07-13       Impact factor: 5.191

2.  Advances in the discovery and development of trematocidal drugs.

Authors:  Jennifer Keiser; Jürg Utzinger
Journal:  Expert Opin Drug Discov       Date:  2007-10       Impact factor: 6.098

3.  The activity of dispiro peroxides against Fasciola hepatica.

Authors:  Xiaofang Wang; Qingjie Zhao; Mireille Vargas; Yuxiang Dong; Kamaraj Sriraghavan; Jennifer Keiser; Jonathan L Vennerstrom
Journal:  Bioorg Med Chem Lett       Date:  2011-07-19       Impact factor: 2.823

Review 4.  Human schistosomiasis.

Authors:  Bruno Gryseels; Katja Polman; Jan Clerinx; Luc Kestens
Journal:  Lancet       Date:  2006-09-23       Impact factor: 79.321

5.  Interactions of mefloquine with praziquantel in the Schistosoma mansoni mouse model and in vitro.

Authors:  Jennifer Keiser; Theresia Manneck; Mireille Vargas
Journal:  J Antimicrob Chemother       Date:  2011-05-20       Impact factor: 5.790

Review 6.  From innovation to application: social-ecological context, diagnostics, drugs and integrated control of schistosomiasis.

Authors:  Jürg Utzinger; Eliézer K N'goran; Conor R Caffrey; Jennifer Keiser
Journal:  Acta Trop       Date:  2010-09-08       Impact factor: 3.112

7.  Efficacy of artesunate with sulfalene plus pyrimethamine versus praziquantel for treatment of Schistosoma mansoni in Kenyan children: an open-label randomised controlled trial.

Authors:  Charles O Obonyo; Erick M O Muok; Pauline N M Mwinzi
Journal:  Lancet Infect Dis       Date:  2010-08-10       Impact factor: 25.071

8.  Schistosomicidal and antifecundity effects of oral treatment of synthetic endoperoxide N-89.

Authors:  Toshie Taniguchi; Takashi Kumagai; Rieko Shimogawara; Shizuko Ichinose; Akiko Hiramoto; Akira Sato; Masayuki Morita; Masatomo Nojima; Hye-Sook Kim; Yusuke Wataya; Nobuo Ohta
Journal:  Parasitol Int       Date:  2011-03-21       Impact factor: 2.230

9.  Spiro and dispiro-1,2,4-trioxolanes as antimalarial peroxides: charting a workable structure-activity relationship using simple prototypes.

Authors:  Yuxiang Dong; Jacques Chollet; Hugues Matile; Susan A Charman; Francis C K Chiu; William N Charman; Bernard Scorneaux; Heinrich Urwyler; Josefina Santo Tomas; Christian Scheurer; Christopher Snyder; Arnulf Dorn; Xiaofang Wang; Jean M Karle; Yuanqing Tang; Sergio Wittlin; Reto Brun; Jonathan L Vennerstrom
Journal:  J Med Chem       Date:  2005-07-28       Impact factor: 7.446

Review 10.  A wake up call for urinary schistosomiasis: reconciling research effort with public health importance.

Authors:  D Rollinson
Journal:  Parasitology       Date:  2009-07-23       Impact factor: 3.234
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  15 in total

1.  Structure-Activity Relationship of Antischistosomal Ozonide Carboxylic Acids.

Authors:  Jianbo Wu; Xiaofang Wang; Francis C K Chiu; Cécile Häberli; David M Shackleford; Eileen Ryan; Sriraghavan Kamaraj; Vivek J Bulbule; Alexander I Wallick; Yuxiang Dong; Karen L White; Paul H Davis; Susan A Charman; Jennifer Keiser; Jonathan L Vennerstrom
Journal:  J Med Chem       Date:  2020-03-19       Impact factor: 7.446

2.  In vitro and in vivo activity of 3-alkoxy-1,2-dioxolanes against Schistosoma mansoni.

Authors:  Katrin Ingram; Charles E Schiaffo; Wantanee Sittiwong; Evan Benner; Patrick H Dussault; Jennifer Keiser
Journal:  J Antimicrob Chemother       Date:  2012-05-02       Impact factor: 5.790

Review 3.  Rearrangements of organic peroxides and related processes.

Authors:  Ivan A Yaremenko; Vera A Vil'; Dmitry V Demchuk; Alexander O Terent'ev
Journal:  Beilstein J Org Chem       Date:  2016-08-03       Impact factor: 2.883

4.  Pharmacokinetics of the Antischistosomal Lead Ozonide OZ418 in Uninfected Mice Determined by Liquid Chromatography-Tandem Mass Spectrometry.

Authors:  Anna Leonidova; Mireille Vargas; Jörg Huwyler; Jennifer Keiser
Journal:  Antimicrob Agents Chemother       Date:  2016-11-21       Impact factor: 5.191

5.  Effect of ozonide OZ418 against Schistosoma japonicum harbored in mice.

Authors:  Jian Xue; Xiaofang Wang; Yuxiang Dong; Jonathan L Vennerstrom; Shu-hua Xiao
Journal:  Parasitol Res       Date:  2014-06-20       Impact factor: 2.289

6.  Orally active antischistosomal early leads identified from the open access malaria box.

Authors:  Katrin Ingram-Sieber; Noemi Cowan; Gordana Panic; Mireille Vargas; Nuha R Mansour; Quentin D Bickle; Timothy N C Wells; Thomas Spangenberg; Jennifer Keiser
Journal:  PLoS Negl Trop Dis       Date:  2014-01-09

Review 7.  Repurposing drugs for the treatment and control of helminth infections.

Authors:  Gordana Panic; Urs Duthaler; Benjamin Speich; Jennifer Keiser
Journal:  Int J Parasitol Drugs Drug Resist       Date:  2014-07-30       Impact factor: 4.077

Review 8.  Controlling schistosomiasis with praziquantel: How much longer without a viable alternative?

Authors:  Robert Bergquist; Jürg Utzinger; Jennifer Keiser
Journal:  Infect Dis Poverty       Date:  2017-03-28       Impact factor: 4.520

9.  Elimination of Schistosoma mansoni in infected mice by slow release of artemisone.

Authors:  Daniel Gold; Mohammed Alian; Avraham Domb; Yara Karawani; Maysa Jbarien; Jacques Chollet; Richard K Haynes; Ho Ning Wong; Viola Buchholz; Andreas Greiner; Jacob Golenser
Journal:  Int J Parasitol Drugs Drug Resist       Date:  2017-05-04       Impact factor: 4.077

10.  Cyclic Synthetic Peroxides Inhibit Growth of Entomopathogenic Fungus Ascosphaera apis without Toxic Effect on Bumblebees.

Authors:  Ivan A Yaremenko; Mikhail Y Syromyatnikov; Peter S Radulov; Yulia Yu Belyakova; Dmitriy I Fomenkov; Vasily N Popov; Alexander O Terent'ev
Journal:  Molecules       Date:  2020-04-22       Impact factor: 4.411
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