Literature DB >> 21802291

The activity of dispiro peroxides against Fasciola hepatica.

Xiaofang Wang1, Qingjie Zhao, Mireille Vargas, Yuxiang Dong, Kamaraj Sriraghavan, Jennifer Keiser, Jonathan L Vennerstrom.   

Abstract

Dispiro 1,2,4-trioxanes and 1,2,4,5-tetraoxanes had superior efficacy against Fasciola hepatica than the corresponding ozonides (1,2,4-trioxolanes). For highest efficacy, spiroadamantane and carboxymethyl substructures were required. Three compounds completely cured F. hepatica-infected mice at single oral doses of 50mg/kg and two were partially curative at single doses of 25mg/kg.
Copyright © 2011 Elsevier Ltd. All rights reserved.

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Year:  2011        PMID： 21802291      PMCID： PMC3159854          DOI： 10.1016/j.bmcl.2011.07.024

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  27 in total

1.  Structure-activity relationship of an ozonide carboxylic acid (OZ78) against Fasciola hepatica.

Authors:  Qingjie Zhao; Mireille Vargas; Yuxiang Dong; Lin Zhou; Xiaofang Wang; Kamaraj Sriraghavan; Jennifer Keiser; Jonathan L Vennerstrom
Journal:  J Med Chem       Date:  2010-05-27       Impact factor: 7.446

2.  The antimalarial drug artemisinin alkylates heme in infected mice.

Authors:  Anne Robert; Françoise Benoit-Vical; Catherine Claparols; Bernard Meunier
Journal:  Proc Natl Acad Sci U S A       Date:  2005-09-09       Impact factor: 11.205

3.  Advances in the discovery and development of trematocidal drugs.

Authors:  Jennifer Keiser; Jürg Utzinger
Journal:  Expert Opin Drug Discov       Date:  2007-10       Impact factor: 6.098

4.  Discovery and structure-activity relationship of a novel spirocarbamate series of NPY Y5 antagonists.

Authors:  Colin P Leslie; Jonathan Bentley; Matteo Biagetti; Stefania Contini; Romano Di Fabio; Daniele Donati; Thorsten Genski; Sebastien Guery; Angelica Mazzali; Giancarlo Merlo; Domenica A Pizzi; Fabiola Sacco; Catia Seri; Michela Tessari; Laura Zonzini; Laura Caberlotto
Journal:  Bioorg Med Chem Lett       Date:  2010-08-12       Impact factor: 2.823

5.  Resistance of Fasciola hepatica against triclabendazole in cattle and sheep in The netherlands.

Authors:  L Moll; C P Gaasenbeek; P Vellema; F H Borgsteede
Journal:  Vet Parasitol       Date:  2000-07-24       Impact factor: 2.738

Review 6.  Food-borne trematodiasis: current chemotherapy and advances with artemisinins and synthetic trioxolanes.

Authors:  Jennifer Keiser; Jürg Utzinger
Journal:  Trends Parasitol       Date:  2007-10-22

7.  Identification of an antimalarial synthetic trioxolane drug development candidate.

Authors:  Jonathan L Vennerstrom; Sarah Arbe-Barnes; Reto Brun; Susan A Charman; Francis C K Chiu; Jacques Chollet; Yuxiang Dong; Arnulf Dorn; Daniel Hunziker; Hugues Matile; Kylie McIntosh; Maniyan Padmanilayam; Josefina Santo Tomas; Christian Scheurer; Bernard Scorneaux; Yuanqing Tang; Heinrich Urwyler; Sergio Wittlin; William N Charman
Journal:  Nature       Date:  2004-08-19       Impact factor: 49.962

8.  Peroxide bond-dependent antiplasmodial specificity of artemisinin and OZ277 (RBx11160).

Authors:  Marcel Kaiser; Sergio Wittlin; Angela Nehrbass-Stuedli; Yuxiang Dong; Xiaofang Wang; Andrew Hemphill; Hugues Matile; Reto Brun; Jonathan L Vennerstrom
Journal:  Antimicrob Agents Chemother       Date:  2007-06-11       Impact factor: 5.191

Review 9.  Triclabendazole progress report, 2005-2009: an advancement of learning?

Authors:  I Fairweather
Journal:  J Helminthol       Date:  2009-04-15       Impact factor: 2.170

10.  Broadly applicable synthesis of 1,2,4,5-tetraoxanes.

Authors:  Prasanta Ghorai; Patrick H Dussault
Journal:  Org Lett       Date:  2009-01-01       Impact factor: 6.005
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  7 in total

1.  In vivo activity of aryl ozonides against Schistosoma species.

Authors:  Jennifer Keiser; Katrin Ingram; Mireille Vargas; Jacques Chollet; Xiaofang Wang; Yuxiang Dong; Jonathan L Vennerstrom
Journal:  Antimicrob Agents Chemother       Date:  2011-11-21       Impact factor: 5.191

2.  Novel endoperoxide-based transmission-blocking antimalarials with liver- and blood-schizontocidal activities.

Authors:  Daniela Miranda; Rita Capela; Inês S Albuquerque; Patrícia Meireles; Isa Paiva; Fátima Nogueira; Richard Amewu; Jiri Gut; Philip J Rosenthal; Rudi Oliveira; Maria M Mota; Rui Moreira; Francesc Marti; Miguel Prudêncio; Paul M O'Neill; Francisca Lopes
Journal:  ACS Med Chem Lett       Date:  2013-12-20       Impact factor: 4.345

Review 3.  Lewis Acids and Heteropoly Acids in the Synthesis of Organic Peroxides.

Authors:  Ivan A Yaremenko; Peter S Radulov; Yulia Yu Belyakova; Dmitriy I Fomenkov; Svetlana B Tsogoeva; Alexander O Terent'ev
Journal:  Pharmaceuticals (Basel)       Date:  2022-04-13

Review 4.  Repurposing drugs for the treatment and control of helminth infections.

Authors:  Gordana Panic; Urs Duthaler; Benjamin Speich; Jennifer Keiser
Journal:  Int J Parasitol Drugs Drug Resist       Date:  2014-07-30       Impact factor: 4.077

Review 5.  Peroxides with Anthelmintic, Antiprotozoal, Fungicidal and Antiviral Bioactivity: Properties, Synthesis and Reactions.

Authors:  Vera A Vil'; Ivan A Yaremenko; Alexey I Ilovaisky; Alexander O Terent'ev
Journal:  Molecules       Date:  2017-11-02       Impact factor: 4.411

6.  Exogenous Iron Increases Fasciocidal Activity and Hepatocellular Toxicity of the Synthetic Endoperoxides OZ78 and MT04.

Authors:  Karin Brecht; Carla Kirchhofer; Jamal Bouitbir; Francesca Trapani; Jennifer Keiser; Stephan Krähenbühl
Journal:  Int J Mol Sci       Date:  2019-10-01       Impact factor: 5.923

Review 7.  Drug resistance in liver flukes.

Authors:  I Fairweather; G P Brennan; R E B Hanna; M W Robinson; P J Skuce
Journal:  Int J Parasitol Drugs Drug Resist       Date:  2020-01-10       Impact factor: 4.077
  7 in total

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