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Literature DB >> 17562801

Peroxide bond-dependent antiplasmodial specificity of artemisinin and OZ277 (RBx11160).

Marcel Kaiser¹, Sergio Wittlin, Angela Nehrbass-Stuedli, Yuxiang Dong, Xiaofang Wang, Andrew Hemphill, Hugues Matile, Reto Brun, Jonathan L Vennerstrom.

Abstract

Using nonperoxidic analogs of artemisinin and OZ277 (RBx11160), the strong in vitro antiplasmodial activities of the latter two compounds were shown to be peroxide bond dependent. In contrast, the weak activities of artemisinin and OZ277 against six other protozoan parasites were peroxide bond independent. These data support the iron-dependent artemisinin alkylation hypothesis.

Entities: Chemical

Mesh：

Substances：

Year: 2007 PMID： 17562801 PMCID： PMC1932508 DOI： 10.1128/AAC.00225-07

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

42 in total

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33 in total

1. Structure-activity relationship of an ozonide carboxylic acid (OZ78) against Fasciola hepatica.

Authors: Qingjie Zhao; Mireille Vargas; Yuxiang Dong; Lin Zhou; Xiaofang Wang; Kamaraj Sriraghavan; Jennifer Keiser; Jonathan L Vennerstrom
Journal: J Med Chem Date: 2010-05-27 Impact factor: 7.446

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Authors: Jianbo Wu; Xiaofang Wang; Francis C K Chiu; Cécile Häberli; David M Shackleford; Eileen Ryan; Sriraghavan Kamaraj; Vivek J Bulbule; Alexander I Wallick; Yuxiang Dong; Karen L White; Paul H Davis; Susan A Charman; Jennifer Keiser; Jonathan L Vennerstrom
Journal: J Med Chem Date: 2020-03-19 Impact factor: 7.446

3. The activity of dispiro peroxides against Fasciola hepatica.

Authors: Xiaofang Wang; Qingjie Zhao; Mireille Vargas; Yuxiang Dong; Kamaraj Sriraghavan; Jennifer Keiser; Jonathan L Vennerstrom
Journal: Bioorg Med Chem Lett Date: 2011-07-19 Impact factor: 2.823

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Authors: Nectarios Klonis; Maria P Crespo-Ortiz; Iveta Bottova; Nurhidanatasha Abu-Bakar; Shannon Kenny; Philip J Rosenthal; Leann Tilley
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Journal: Antimicrob Agents Chemother Date: 2014-07-21 Impact factor: 5.191

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Authors: Matthias A Fügi; Sergio Wittlin; Yuxiang Dong; Jonathan L Vennerstrom
Journal: Antimicrob Agents Chemother Date: 2009-12-22 Impact factor: 5.191